𝕏

Task 55971815

Name HuVeMOp_20240703211647185001_ORdGradInc_k_26-Pueyo_APDR-conf_756_1
Workunit 26580887
Created 3 Jul 2024, 19:17:14 UTC
Sent 3 Jul 2024, 20:31:02 UTC
Report deadline 7 Jul 2024, 6:07:02 UTC
Received 5 Jul 2024, 11:25:29 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 222140
Run time 1 hours 40 min
CPU time 1 hours 9 min 51 sec
Validate state Valid
Credit 57.81
Device peak FLOPS 3.88 GFLOPS
Application version Human ventricular cell models optimization v0.02
arm64-apple-darwin
Peak working set size 2.36 MB
Peak swap size 391.75 GB
Peak disk usage 0.28 MB

Stderr output

<core_client_version>8.0.2</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703211647185001_ORdGradInc_k_26-Pueyo_APDR-conf_756.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703211647185001_ORdGradInc_k_26-Pueyo_APDR-conf_756_1_r1627163398_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703211647185001_ORdGradInc_k_26-Pueyo_APDR-conf_756_1_r1627163398_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 102.623977
     * GNaL_b in INaL: 0.005997
     * Gto_b in Ito: 0.087290
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.032254
     * GKs_b in IKs: 0.001906
     * GK1_b in IK1: 0.166575
     * Gncx_b in INaCa_i: 0.000966
     * Pnak_b in INaK: 71.238071
     * GKb_b in IKb: 0.003788
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.029297
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 709318, states[0] = -94.992333, states[40]= 0.000000
Saving checkpoint... 
Iteration: 10872107, states[0] = -95.090060, states[40]= 0.000000
Saving checkpoint... 
Iteration: 20390209, states[0] = -95.067673, states[40]= 0.000000
Saving checkpoint... 
Iteration: 33826963, states[0] = -95.016404, states[40]= 0.000000
Saving checkpoint... 
Iteration: 43373784, states[0] = -95.028205, states[40]= 0.000000
Saving checkpoint... 
Iteration: 54583457, states[0] = -5.532472, states[40]= 0.003293
Saving checkpoint... 
Iteration: 64435472, states[0] = -95.032213, states[40]= 0.000000
Saving checkpoint... 
Iteration: 75198720, states[0] = -94.833026, states[40]= 0.000000
Saving checkpoint... 
Iteration: 86800632, states[0] = -94.966752, states[40]= 0.000000
Saving checkpoint... 
Iteration: 95333753, states[0] = -94.986844, states[40]= 0.000000
Saving checkpoint... 
Iteration: 108440752, states[0] = -95.022352, states[40]= 0.000000
Saving checkpoint... 
Iteration: 120042942, states[0] = 14.328852, states[40]= 0.005058
Saving checkpoint... 
Iteration: 131765299, states[0] = -94.928199, states[40]= 0.000000
Saving checkpoint... 
Iteration: 143530427, states[0] = 18.538429, states[40]= 0.005867
Saving checkpoint... 
Iteration: 154783846, states[0] = -94.945911, states[40]= 0.000000
Saving checkpoint... 
Iteration: 165368892, states[0] = -94.998263, states[40]= 0.000000
Saving checkpoint... 
Iteration: 177618878, states[0] = -36.984156, states[40]= 0.000203
Saving checkpoint... 
Iteration: 187356657, states[0] = -94.992731, states[40]= 0.000000
Saving checkpoint... 
Iteration: 199136023, states[0] = -54.882997, states[40]= 0.000013
Saving checkpoint... 
Iteration: 210023987, states[0] = 20.264261, states[40]= 0.007208
Saving checkpoint... 
Iteration: 222735289, states[0] = -94.887325, states[40]= 0.000000
Saving checkpoint... 
Iteration: 235518980, states[0] = 21.291222, states[40]= 0.010372
Saving checkpoint... 
Iteration: 247442937, states[0] = -95.018795, states[40]= 0.000000
Saving checkpoint... 
Iteration: 257185739, states[0] = -94.792589, states[40]= 0.000000
Saving checkpoint... 
Iteration: 269138584, states[0] = -57.744433, states[40]= 0.000008
Saving checkpoint... 
Iteration: 280029967, states[0] = 18.689990, states[40]= 0.005927
Saving checkpoint... 
Iteration: 294376229, states[0] = -95.000284, states[40]= 0.000000
Saving checkpoint... 
Iteration: 307130104, states[0] = -48.403092, states[40]= 0.000037
Saving checkpoint... 
Iteration: 317467960, states[0] = -95.023137, states[40]= 0.000000
Saving checkpoint... 
Iteration: 329006164, states[0] = 25.553337, states[40]= 0.126729
Saving checkpoint... 
Iteration: 339351539, states[0] = -94.989904, states[40]= 0.000000
Saving checkpoint... 
Iteration: 350546746, states[0] = 12.966816, states[40]= 0.004972
Saving checkpoint... 
Iteration: 362099001, states[0] = -18.116161, states[40]= 0.001116
Saving checkpoint... 
Iteration: 373130274, states[0] = -48.584405, states[40]= 0.000036
Saving checkpoint... 
Iteration: 383882464, states[0] = -95.002458, states[40]= 0.000000
Saving checkpoint... 
Iteration: 392945256, states[0] = -95.019090, states[40]= 0.000000
Saving checkpoint... 
Iteration: 403272450, states[0] = -94.933648, states[40]= 0.000000
Saving checkpoint... 
Iteration: 417131297, states[0] = -49.684385, states[40]= 0.000030
Saving checkpoint... 
Iteration: 428773417, states[0] = -94.934621, states[40]= 0.000000
Saving checkpoint... 
Iteration: 438286114, states[0] = -94.946764, states[40]= 0.000000
Saving checkpoint... 
Iteration: 448624725, states[0] = -42.771856, states[40]= 0.000088
Saving checkpoint... 
Iteration: 460568761, states[0] = 3.789905, states[40]= 0.004616
Saving checkpoint... 
Iteration: 472465159, states[0] = -95.022576, states[40]= 0.000000
Saving checkpoint... 
Iteration: 482426084, states[0] = -95.014935, states[40]= 0.000000
Saving checkpoint... 
Iteration: 494521269, states[0] = 20.859053, states[40]= 0.008475
Saving checkpoint... 
Iteration: 507030440, states[0] = 18.551712, states[40]= 0.005867
Saving checkpoint... 
Iteration: 517151200, states[0] = -74.172661, states[40]= 0.000000
Saving checkpoint... 
Iteration: 529624146, states[0] = -42.182014, states[40]= 0.000096
Saving checkpoint... 
Iteration: 541093646, states[0] = -13.129570, states[40]= 0.001747
Saving checkpoint... 
Iteration: 554081544, states[0] = -3.402040, states[40]= 0.003698
Saving checkpoint... 
Iteration: 568057208, states[0] = 8.883485, states[40]= 0.004849
Saving checkpoint... 
Iteration: 581499437, states[0] = -95.027240, states[40]= 0.000000
Saving checkpoint... 
Iteration: 594659989, states[0] = -88.822765, states[40]= 0.000000
Saving checkpoint... 
Iteration: 607397626, states[0] = -95.007255, states[40]= 0.000000
Saving checkpoint... 
Iteration: 618048131, states[0] = 12.445567, states[40]= 0.004949
Saving checkpoint... 
Iteration: 632632076, states[0] = -50.526967, states[40]= 0.000026
Saving checkpoint... 
Iteration: 643033730, states[0] = 17.540256, states[40]= 0.005532
Saving checkpoint... 
Iteration: 654443088, states[0] = -95.018484, states[40]= 0.000000
Saving checkpoint... 
Iteration: 664634210, states[0] = -52.857016, states[40]= 0.000018
Saving checkpoint... 
Iteration: 677684958, states[0] = -94.789971, states[40]= 0.000000
Saving checkpoint... 
Iteration: 688987424, states[0] = -95.025679, states[40]= 0.000000
Saving checkpoint... 
Iteration: 700437917, states[0] = -95.017398, states[40]= 0.000000
Saving checkpoint... 
Iteration: 712609716, states[0] = -28.202416, states[40]= 0.000562
Saving checkpoint... 
Iteration: 726146833, states[0] = -67.807743, states[40]= 0.000001
Saving checkpoint... 
Iteration: 738002576, states[0] = 39.626013, states[40]= 0.125459
Saving checkpoint... 
Iteration: 750801489, states[0] = -94.959313, states[40]= 0.000000
Saving checkpoint... 
Iteration: 763628309, states[0] = -46.494046, states[40]= 0.000050
Saving checkpoint... 
Iteration: 776815081, states[0] = -94.969050, states[40]= 0.000000
Saving checkpoint... 
Iteration: 787599821, states[0] = -18.887748, states[40]= 0.001051
Saving checkpoint... 
Iteration: 801190983, states[0] = -94.805062, states[40]= 0.000000
Saving checkpoint... 
Iteration: 810292452, states[0] = -94.952011, states[40]= 0.000000
Saving checkpoint... 
Iteration: 823786594, states[0] = -94.946929, states[40]= 0.000000
Saving checkpoint... 
Iteration: 837214540, states[0] = -94.852253, states[40]= 0.000000
Saving checkpoint... 
Iteration: 848293870, states[0] = -94.953169, states[40]= 0.000000
Saving checkpoint... 
Iteration: 859331115, states[0] = -94.978936, states[40]= 0.000000
Saving checkpoint... 
Iteration: 872084986, states[0] = -5.845139, states[40]= 0.003212
Saving checkpoint... 
Iteration: 883454216, states[0] = -95.020431, states[40]= 0.000000
Saving checkpoint... 
Iteration: 894170623, states[0] = -94.491749, states[40]= 0.000000
Saving checkpoint... 
Iteration: 905658173, states[0] = -86.101461, states[40]= 0.000000
Saving checkpoint... 
Iteration: 917949524, states[0] = -95.019547, states[40]= 0.000000
Saving checkpoint... 
Iteration: 928665847, states[0] = -93.552247, states[40]= 0.000000
Saving checkpoint... 
Iteration: 939867053, states[0] = -94.996266, states[40]= 0.000000
Saving checkpoint... 
Iteration: 950414189, states[0] = -95.011685, states[40]= 0.000000
Saving checkpoint... 
Iteration: 962367435, states[0] = -94.996405, states[40]= 0.000000
Saving checkpoint... 
Iteration: 974522782, states[0] = 20.539560, states[40]= 0.007680
Saving checkpoint... 
Iteration: 984589422, states[0] = -9.396202, states[40]= 0.002455
Saving checkpoint... 
Iteration: 993569502, states[0] = 3.430419, states[40]= 0.004590
Saving checkpoint... 
Iteration: 1003275618, states[0] = -94.936449, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1013710061, states[0] = -94.843803, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1026607033, states[0] = -25.673749, states[40]= 0.000682
Saving checkpoint... 
Iteration: 1038812012, states[0] = -94.966783, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1050951590, states[0] = -95.019840, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1063301854, states[0] = -94.959379, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1073559818, states[0] = 7.801011, states[40]= 0.004817
Saving checkpoint... 
Iteration: 1085627194, states[0] = -45.322759, states[40]= 0.000060
Saving checkpoint... 
Iteration: 1096851714, states[0] = -94.989466, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1108326472, states[0] = -94.976046, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1118944730, states[0] = -95.018492, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1130932063, states[0] = -95.015849, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1144614164, states[0] = -32.418279, states[40]= 0.000365
Saving checkpoint... 
Iteration: 1160071562, states[0] = 2.402216, states[40]= 0.004503
Saving checkpoint... 
Iteration: 1173152299, states[0] = -75.948157, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1183446424, states[0] = -95.018777, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1195401794, states[0] = -95.008097, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1205678399, states[0] = -94.755852, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1216802904, states[0] = -94.960073, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1228642685, states[0] = -62.536025, states[40]= 0.000003
Saving checkpoint... 
Iteration: 1240610870, states[0] = -29.292444, states[40]= 0.000509
Saving checkpoint... 
Iteration: 1249384790, states[0] = -95.002673, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1260742249, states[0] = -94.896591, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1274027862, states[0] = 19.284176, states[40]= 0.006248
Saving checkpoint... 
Iteration: 1284931253, states[0] = -95.015565, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1295173480, states[0] = -94.659113, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1304868448, states[0] = -94.996579, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1315952538, states[0] = -95.019833, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1327181358, states[0] = -94.775862, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1341007490, states[0] = 24.075857, states[40]= 0.095529
Saving checkpoint... 
Iteration: 1352069246, states[0] = 3.555347, states[40]= 0.004599
Saving checkpoint... 
Iteration: 1365033839, states[0] = 17.505587, states[40]= 0.005523
Saving checkpoint... 
Iteration: 1377036875, states[0] = 16.506558, states[40]= 0.005311
Saving checkpoint... 
Iteration: 1389064133, states[0] = 5.933020, states[40]= 0.004743
Saving checkpoint... 
Iteration: 1401627228, states[0] = -45.358071, states[40]= 0.000059
Saving checkpoint... 
Iteration: 1412519796, states[0] = 21.144857, states[40]= 0.009570
Saving checkpoint... 
Iteration: 1421479937, states[0] = -95.024163, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1434075258, states[0] = 0.434314, states[40]= 0.004293
Saving checkpoint... 
Iteration: 1443700597, states[0] = -94.824938, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1454939228, states[0] = -95.017157, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1467663777, states[0] = -92.536088, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1481366304, states[0] = -94.995593, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1491879329, states[0] = -95.000587, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1503654592, states[0] = 6.261127, states[40]= 0.005295
Saving checkpoint... 
Iteration: 1512933857, states[0] = 16.080976, states[40]= 0.006498
Saving checkpoint... 
Iteration: 1524658659, states[0] = 3.324538, states[40]= 0.005164
Saving checkpoint... 
Iteration: 1536612647, states[0] = 22.862155, states[40]= 0.030385
Saving checkpoint... 
Iteration: 1550130946, states[0] = 16.905335, states[40]= 0.006813
Saving checkpoint... 
Iteration: 1561813160, states[0] = 22.630165, states[40]= 0.027417
Saving checkpoint... 
Iteration: 1573956401, states[0] = -95.063240, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1585204893, states[0] = 29.475739, states[40]= 0.134878
Saving checkpoint... 
Iteration: 1597267970, states[0] = -3.964715, states[40]= 0.004054
Saving checkpoint... 
Iteration: 1608030648, states[0] = 16.874376, states[40]= 0.006844
Saving checkpoint... 
Iteration: 1619822289, states[0] = -64.924117, states[40]= 0.000003
Saving checkpoint... 
Iteration: 1630262226, states[0] = 0.258305, states[40]= 0.004826
Saving checkpoint... 
Iteration: 1642626531, states[0] = -71.310498, states[40]= 0.000001
Saving checkpoint... 
Iteration: 1654619725, states[0] = -61.519708, states[40]= 0.000005
Saving checkpoint... 
Iteration: 1666624350, states[0] = -67.985699, states[40]= 0.000002
Saving checkpoint... 
Iteration: 1676896188, states[0] = -95.178638, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1687448909, states[0] = -95.257341, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1698607227, states[0] = 25.381612, states[40]= 0.096099
Saving checkpoint... 
Iteration: 1709211096, states[0] = -50.651067, states[40]= 0.000027
Saving checkpoint... 
Iteration: 1723020093, states[0] = -62.040943, states[40]= 0.000004
Saving checkpoint... 
Iteration: 1732178120, states[0] = -95.284846, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1744744692, states[0] = -95.252692, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1756595353, states[0] = -32.604217, states[40]= 0.000350
Saving checkpoint... 
Iteration: 1769715063, states[0] = 22.061651, states[40]= 0.019518
Saving checkpoint... 
Iteration: 1781695938, states[0] = -95.297785, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1793535055, states[0] = -86.649054, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1804724814, states[0] = -94.917815, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1817483245, states[0] = -95.064422, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1828820027, states[0] = -95.000723, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1839569273, states[0] = 3.001819, states[40]= 0.004576
Saving checkpoint... 
Iteration: 1849821711, states[0] = -94.988304, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1862671397, states[0] = -94.610428, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1875739193, states[0] = -94.899117, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1888278671, states[0] = -94.943795, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1899287792, states[0] = -94.950799, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1908220270, states[0] = -94.864460, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1919328306, states[0] = -94.978494, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1930876615, states[0] = -95.000629, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1939469785, states[0] = -95.023327, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1950035825, states[0] = 16.847571, states[40]= 0.005376
Saving checkpoint... 
Iteration: 1961808118, states[0] = -94.963907, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1970798701, states[0] = -94.956677, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1981447634, states[0] = -95.018715, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1994303436, states[0] = -94.960095, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2004052125, states[0] = 10.909234, states[40]= 0.004900
Saving checkpoint... 
Iteration: 2015813608, states[0] = -94.967261, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2027879280, states[0] = -95.000221, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2040888569, states[0] = -95.003398, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2048246235, states[0] = -94.901515, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2061030629, states[0] = 18.495795, states[40]= 0.005843
Saving checkpoint... 
Iteration: 2071532103, states[0] = 18.050404, states[40]= 0.005681
Saving checkpoint... 
Iteration: 2082325651, states[0] = -94.974842, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2099521549, states[0] = 20.802147, states[40]= 0.008306
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.902096
 - CaMKt in component CaMK (millimolar): 0.007114
 - cass in component intracellular_ions (millimolar): 0.000074
 - nai in component intracellular_ions (millimolar): 6.578470
 - nass in component intracellular_ions (millimolar): 6.578530
 - ki in component intracellular_ions (millimolar): 145.396829
 - kss in component intracellular_ions (millimolar): 145.396809
 - cansr in component intracellular_ions (millimolar): 1.320417
 - cajsr in component intracellular_ions (millimolar): 1.282227
 - cai in component intracellular_ions (millimolar): 0.000075
 - m in component INa (dimensionless): 0.003618
 - hf in component INa (dimensionless): 0.880005
 - hs in component INa (dimensionless): 0.880000
 - j in component INa (dimensionless): 0.879971
 - hsp in component INa (dimensionless): 0.725838
 - jp in component INa (dimensionless): 0.879952
 - mL in component INaL (dimensionless): 0.000050
 - hL in component INaL (dimensionless): 0.709871
 - hLp in component INaL (dimensionless): 0.451869
 - a in component Ito (dimensionless): 0.000623
 - iF in component Ito (dimensionless): 0.999870
 - iS in component Ito (dimensionless): 0.620831
 - ap in component Ito (dimensionless): 0.000318
 - iFp in component Ito (dimensionless): 0.999870
 - iSp in component Ito (dimensionless): 0.695695
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.935159
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999885
 - jca in component ICaL (dimensionless): 0.999978
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001634
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.329070
 - xs1 in component IKs (dimensionless): 0.242336
 - xs2 in component IKs (dimensionless): 0.000088
 - xk1 in component IK1 (dimensionless): 0.997337
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
12:24:33 (81149): called boinc_finish(0)

</stderr_txt>
]]>


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