𝕏

Task 55454927

Name HuVeMOp_20240630170541889546_ORdGradInc_k_25-Pueyo_APDR-conf_496_0
Workunit 26333433
Created 30 Jun 2024, 15:05:48 UTC
Sent 30 Jun 2024, 15:50:12 UTC
Report deadline 4 Jul 2024, 1:26:12 UTC
Received 3 Jul 2024, 16:09:32 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 220129
Run time 4 hours 9 min 45 sec
CPU time 3 hours 6 min 24 sec
Validate state Valid
Credit 61.48
Device peak FLOPS 3.26 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-apple-darwin
Peak working set size 2.07 MB
Peak swap size 4.10 GB
Peak disk usage 0.51 MB

Stderr output

<core_client_version>7.20.2</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170541889546_ORdGradInc_k_25-Pueyo_APDR-conf_496.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170541889546_ORdGradInc_k_25-Pueyo_APDR-conf_496_0_r1101506148_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170541889546_ORdGradInc_k_25-Pueyo_APDR-conf_496_0_r1101506148_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 116.308203
     * GNaL_b in INaL: 0.006843
     * Gto_b in Ito: 0.085731
     * PCa_b in ICaL: 0.000081
     * GKr_b in IKr: 0.032955
     * GKs_b in IKs: 0.002132
     * GK1_b in IK1: 0.148638
     * Gncx_b in INaCa_i: 0.000970
     * Pnak_b in INaK: 74.755530
     * GKb_b in IKb: 0.003844
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.019184
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 5507950, states[0] = 23.622179, states[40]= 0.084839
Saving checkpoint... 
Iteration: 11005368, states[0] = 27.440080, states[40]= 0.139731
Saving checkpoint... 
Iteration: 16054767, states[0] = 8.432952, states[40]= 0.004934
Saving checkpoint... 
Iteration: 20799565, states[0] = -95.044787, states[40]= 0.000000
Saving checkpoint... 
Iteration: 25154194, states[0] = -86.703107, states[40]= 0.000000
Saving checkpoint... 
Iteration: 30320793, states[0] = -95.033525, states[40]= 0.000000
Saving checkpoint... 
Iteration: 34483756, states[0] = -95.083490, states[40]= 0.000000
Saving checkpoint... 
Iteration: 39528262, states[0] = 19.051254, states[40]= 0.006432
Saving checkpoint... 
Iteration: 43836656, states[0] = -95.019219, states[40]= 0.000000
Saving checkpoint... 
Iteration: 48147659, states[0] = -72.603968, states[40]= 0.000001
Saving checkpoint... 
Iteration: 52838678, states[0] = -95.009532, states[40]= 0.000000
Saving checkpoint... 
Iteration: 58476928, states[0] = -95.050742, states[40]= 0.000000
Saving checkpoint... 
Iteration: 61350761, states[0] = -95.008718, states[40]= 0.000000
Saving checkpoint... 
Iteration: 65728095, states[0] = -94.877107, states[40]= 0.000000
Saving checkpoint... 
Iteration: 70771625, states[0] = -94.938151, states[40]= 0.000000
Saving checkpoint... 
Iteration: 74839899, states[0] = -94.993988, states[40]= 0.000000
Saving checkpoint... 
Iteration: 78562604, states[0] = 6.546210, states[40]= 0.004842
Saving checkpoint... 
Iteration: 83340956, states[0] = -94.990804, states[40]= 0.000000
Saving checkpoint... 
Iteration: 88377171, states[0] = -95.007065, states[40]= 0.000000
Saving checkpoint... 
Iteration: 93265313, states[0] = -94.921010, states[40]= 0.000000
Saving checkpoint... 
Iteration: 97680361, states[0] = -94.734533, states[40]= 0.000000
Saving checkpoint... 
Iteration: 101596406, states[0] = -16.024666, states[40]= 0.001343
Saving checkpoint... 
Iteration: 107127121, states[0] = -46.127272, states[40]= 0.000053
Saving checkpoint... 
Iteration: 111252069, states[0] = -94.899164, states[40]= 0.000000
Saving checkpoint... 
Iteration: 115764505, states[0] = -94.915241, states[40]= 0.000000
Saving checkpoint... 
Iteration: 120548249, states[0] = 12.619532, states[40]= 0.005058
Saving checkpoint... 
Iteration: 125356802, states[0] = -94.990239, states[40]= 0.000000
Saving checkpoint... 
Iteration: 128721188, states[0] = -94.844931, states[40]= 0.000000
Saving checkpoint... 
Iteration: 133505090, states[0] = 28.790587, states[40]= 0.146094
Saving checkpoint... 
Iteration: 138801510, states[0] = -94.951876, states[40]= 0.000000
Saving checkpoint... 
Iteration: 143880092, states[0] = -94.999311, states[40]= 0.000000
Saving checkpoint... 
Iteration: 149192072, states[0] = -94.779373, states[40]= 0.000000
Saving checkpoint... 
Iteration: 154051783, states[0] = 11.281891, states[40]= 0.005000
Saving checkpoint... 
Iteration: 158120968, states[0] = -39.435584, states[40]= 0.000143
Saving checkpoint... 
Iteration: 162862983, states[0] = -94.990838, states[40]= 0.000000
Saving checkpoint... 
Iteration: 166840600, states[0] = -94.978746, states[40]= 0.000000
Saving checkpoint... 
Iteration: 171096098, states[0] = -15.430545, states[40]= 0.001416
Saving checkpoint... 
Iteration: 176196054, states[0] = -94.788284, states[40]= 0.000000
Saving checkpoint... 
Iteration: 181767712, states[0] = -94.915010, states[40]= 0.000000
Saving checkpoint... 
Iteration: 185870032, states[0] = -94.993511, states[40]= 0.000000
Saving checkpoint... 
Iteration: 191045934, states[0] = 13.551808, states[40]= 0.005106
Saving checkpoint... 
Iteration: 195697390, states[0] = -94.791096, states[40]= 0.000000
Saving checkpoint... 
Iteration: 200820492, states[0] = -94.964880, states[40]= 0.000000
Saving checkpoint... 
Iteration: 205092269, states[0] = -11.847494, states[40]= 0.001985
Saving checkpoint... 
Iteration: 208548633, states[0] = 12.526233, states[40]= 0.005050
Saving checkpoint... 
Iteration: 213064916, states[0] = 5.773287, states[40]= 0.004792
Saving checkpoint... 
Iteration: 216852299, states[0] = -94.984483, states[40]= 0.000000
Saving checkpoint... 
Iteration: 221580573, states[0] = -2.634070, states[40]= 0.003867
Saving checkpoint... 
Iteration: 225896185, states[0] = -95.003471, states[40]= 0.000000
Saving checkpoint... 
Iteration: 230391213, states[0] = -95.001662, states[40]= 0.000000
Saving checkpoint... 
Iteration: 235475648, states[0] = -95.023092, states[40]= 0.000000
Saving checkpoint... 
Iteration: 240315381, states[0] = -94.960811, states[40]= 0.000000
Saving checkpoint... 
Iteration: 246057010, states[0] = 9.196583, states[40]= 0.004932
Saving checkpoint... 
Iteration: 250968689, states[0] = -95.021835, states[40]= 0.000000
Saving checkpoint... 
Iteration: 255308103, states[0] = -94.955030, states[40]= 0.000000
Saving checkpoint... 
Iteration: 258683974, states[0] = -94.749340, states[40]= 0.000000
Saving checkpoint... 
Iteration: 263216771, states[0] = -94.832858, states[40]= 0.000000
Saving checkpoint... 
Iteration: 266707951, states[0] = -94.814425, states[40]= 0.000000
Saving checkpoint... 
Iteration: 271977258, states[0] = -95.023249, states[40]= 0.000000
Saving checkpoint... 
Iteration: 276246720, states[0] = -94.885614, states[40]= 0.000000
Saving checkpoint... 
Iteration: 281107181, states[0] = -25.956904, states[40]= 0.000665
Saving checkpoint... 
Iteration: 286482048, states[0] = -95.023993, states[40]= 0.000000
Saving checkpoint... 
Iteration: 291347263, states[0] = -94.981494, states[40]= 0.000000
Saving checkpoint... 
Iteration: 295229410, states[0] = -94.856913, states[40]= 0.000000
Saving checkpoint... 
Iteration: 299329930, states[0] = -94.970977, states[40]= 0.000000
Saving checkpoint... 
Iteration: 303584834, states[0] = -5.620721, states[40]= 0.003283
Saving checkpoint... 
Iteration: 307734705, states[0] = -94.866190, states[40]= 0.000000
Saving checkpoint... 
Iteration: 311276629, states[0] = -94.924734, states[40]= 0.000000
Saving checkpoint... 
Iteration: 316075341, states[0] = 0.540778, states[40]= 0.004343
Saving checkpoint... 
Iteration: 320159866, states[0] = -87.758293, states[40]= 0.000000
Saving checkpoint... 
Iteration: 325167584, states[0] = -93.639177, states[40]= 0.000000
Saving checkpoint... 
Iteration: 329793215, states[0] = -94.941819, states[40]= 0.000000
Saving checkpoint... 
Iteration: 333381785, states[0] = -94.997833, states[40]= 0.000000
Saving checkpoint... 
Iteration: 338571618, states[0] = 2.541402, states[40]= 0.004559
Saving checkpoint... 
Iteration: 343913418, states[0] = -95.008809, states[40]= 0.000000
Saving checkpoint... 
Iteration: 349053231, states[0] = 10.730610, states[40]= 0.004980
Saving checkpoint... 
Iteration: 353556951, states[0] = 9.222454, states[40]= 0.004933
Saving checkpoint... 
Iteration: 358427954, states[0] = -95.012856, states[40]= 0.000000
Saving checkpoint... 
Iteration: 363466049, states[0] = -95.021210, states[40]= 0.000000
Saving checkpoint... 
Iteration: 368051846, states[0] = 11.279624, states[40]= 0.004999
Saving checkpoint... 
Iteration: 373329084, states[0] = -94.970354, states[40]= 0.000000
Saving checkpoint... 
Iteration: 378300562, states[0] = -94.948491, states[40]= 0.000000
Saving checkpoint... 
Iteration: 382654562, states[0] = -79.599203, states[40]= 0.000000
Saving checkpoint... 
Iteration: 385966818, states[0] = -95.021334, states[40]= 0.000000
Saving checkpoint... 
Iteration: 391382337, states[0] = -94.998012, states[40]= 0.000000
Saving checkpoint... 
Iteration: 396434198, states[0] = -95.014412, states[40]= 0.000000
Saving checkpoint... 
Iteration: 400710578, states[0] = -94.819911, states[40]= 0.000000
Saving checkpoint... 
Iteration: 405699031, states[0] = -94.794359, states[40]= 0.000000
Saving checkpoint... 
Iteration: 409978516, states[0] = -95.023326, states[40]= 0.000000
Saving checkpoint... 
Iteration: 413971128, states[0] = -95.022082, states[40]= 0.000000
Saving checkpoint... 
Iteration: 418887379, states[0] = -94.999960, states[40]= 0.000000
Saving checkpoint... 
Iteration: 423647067, states[0] = -68.667408, states[40]= 0.000001
Saving checkpoint... 
Iteration: 428600577, states[0] = -19.651912, states[40]= 0.000996
Saving checkpoint... 
Iteration: 432748796, states[0] = -94.888598, states[40]= 0.000000
Saving checkpoint... 
Iteration: 437289588, states[0] = -94.938246, states[40]= 0.000000
Saving checkpoint... 
Iteration: 441210026, states[0] = -94.818713, states[40]= 0.000000
Saving checkpoint... 
Iteration: 446139726, states[0] = -59.757944, states[40]= 0.000005
Saving checkpoint... 
Iteration: 450552433, states[0] = 11.047765, states[40]= 0.004991
Saving checkpoint... 
Iteration: 454653409, states[0] = -77.768421, states[40]= 0.000000
Saving checkpoint... 
Iteration: 458792065, states[0] = -94.940636, states[40]= 0.000000
Saving checkpoint... 
Iteration: 464652766, states[0] = -76.766961, states[40]= 0.000000
Saving checkpoint... 
Iteration: 468930403, states[0] = -95.013416, states[40]= 0.000000
Saving checkpoint... 
Iteration: 471958457, states[0] = -95.019704, states[40]= 0.000000
Saving checkpoint... 
Iteration: 475307631, states[0] = -94.954435, states[40]= 0.000000
Saving checkpoint... 
Iteration: 480451772, states[0] = -95.018346, states[40]= 0.000000
Saving checkpoint... 
Iteration: 485180854, states[0] = -94.726979, states[40]= 0.000000
Saving checkpoint... 
Iteration: 489068914, states[0] = 3.895387, states[40]= 0.004672
Saving checkpoint... 
Iteration: 492484343, states[0] = -95.024194, states[40]= 0.000000
Saving checkpoint... 
Iteration: 497565704, states[0] = 5.416888, states[40]= 0.004772
Saving checkpoint... 
Iteration: 503268311, states[0] = -94.914878, states[40]= 0.000000
Saving checkpoint... 
Iteration: 507687863, states[0] = -94.765138, states[40]= 0.000000
Saving checkpoint... 
Iteration: 512060440, states[0] = 7.755393, states[40]= 0.004882
Saving checkpoint... 
Iteration: 514958869, states[0] = -95.019758, states[40]= 0.000000
Saving checkpoint... 
Iteration: 518659702, states[0] = -87.537419, states[40]= 0.000000
Saving checkpoint... 
Iteration: 522534831, states[0] = 17.518616, states[40]= 0.005645
Saving checkpoint... 
Iteration: 526685520, states[0] = -94.756398, states[40]= 0.000000
Saving checkpoint... 
Iteration: 531590224, states[0] = -10.011718, states[40]= 0.002345
Saving checkpoint... 
Iteration: 535552760, states[0] = 10.918111, states[40]= 0.004987
Saving checkpoint... 
Iteration: 540539686, states[0] = 15.852779, states[40]= 0.005328
Saving checkpoint... 
Iteration: 546120140, states[0] = -38.529475, states[40]= 0.000163
Saving checkpoint... 
Iteration: 551084443, states[0] = -5.327850, states[40]= 0.003345
Saving checkpoint... 
Iteration: 554358182, states[0] = -94.987080, states[40]= 0.000000
Saving checkpoint... 
Iteration: 558653947, states[0] = -78.617512, states[40]= 0.000000
Saving checkpoint... 
Iteration: 563273339, states[0] = -94.920817, states[40]= 0.000000
Saving checkpoint... 
Iteration: 566113159, states[0] = -31.689288, states[40]= 0.000394
Saving checkpoint... 
Iteration: 570477660, states[0] = -95.023087, states[40]= 0.000000
Saving checkpoint... 
Iteration: 574777837, states[0] = -94.925902, states[40]= 0.000000
Saving checkpoint... 
Iteration: 579326902, states[0] = -94.968760, states[40]= 0.000000
Saving checkpoint... 
Iteration: 584404277, states[0] = -95.005807, states[40]= 0.000000
Saving checkpoint... 
Iteration: 588874780, states[0] = -94.994762, states[40]= 0.000000
Saving checkpoint... 
Iteration: 592720432, states[0] = -94.839860, states[40]= 0.000000
Saving checkpoint... 
Iteration: 596271822, states[0] = -94.919025, states[40]= 0.000000
Saving checkpoint... 
Iteration: 602113621, states[0] = -32.135413, states[40]= 0.000375
Saving checkpoint... 
Iteration: 607224707, states[0] = -94.848045, states[40]= 0.000000
Saving checkpoint... 
Iteration: 612560478, states[0] = 7.739112, states[40]= 0.004881
Saving checkpoint... 
Iteration: 617040097, states[0] = 15.706468, states[40]= 0.005308
Saving checkpoint... 
Iteration: 621870157, states[0] = -94.992717, states[40]= 0.000000
Saving checkpoint... 
Iteration: 626369717, states[0] = -94.992516, states[40]= 0.000000
Saving checkpoint... 
Iteration: 631988885, states[0] = -95.024790, states[40]= 0.000000
Saving checkpoint... 
Iteration: 637034538, states[0] = 17.614988, states[40]= 0.005670
Saving checkpoint... 
Iteration: 640782078, states[0] = -94.930455, states[40]= 0.000000
Saving checkpoint... 
Iteration: 644098393, states[0] = -17.567145, states[40]= 0.001172
Saving checkpoint... 
Iteration: 648075361, states[0] = 0.529917, states[40]= 0.004342
Saving checkpoint... 
Iteration: 653514361, states[0] = 22.498173, states[40]= 0.021517
Saving checkpoint... 
Iteration: 658007598, states[0] = 24.804949, states[40]= 0.094458
Saving checkpoint... 
Iteration: 662789660, states[0] = -94.938177, states[40]= 0.000000
Saving checkpoint... 
Iteration: 667668368, states[0] = -93.850065, states[40]= 0.000000
Saving checkpoint... 
Iteration: 671942185, states[0] = -95.016134, states[40]= 0.000000
Saving checkpoint... 
Iteration: 676790855, states[0] = -94.939334, states[40]= 0.000000
Saving checkpoint... 
Iteration: 681728680, states[0] = -94.855332, states[40]= 0.000000
Saving checkpoint... 
Iteration: 685673688, states[0] = -94.540230, states[40]= 0.000000
Saving checkpoint... 
Iteration: 690596104, states[0] = -15.393457, states[40]= 0.001421
Saving checkpoint... 
Iteration: 695302459, states[0] = -94.949946, states[40]= 0.000000
Saving checkpoint... 
Iteration: 699179976, states[0] = -94.717612, states[40]= 0.000000
Saving checkpoint... 
Iteration: 703160662, states[0] = -88.769296, states[40]= 0.000000
Saving checkpoint... 
Iteration: 707928843, states[0] = -95.012868, states[40]= 0.000000
Saving checkpoint... 
Iteration: 711553940, states[0] = 10.447228, states[40]= 0.004971
Saving checkpoint... 
Iteration: 716338324, states[0] = -94.976008, states[40]= 0.000000
Saving checkpoint... 
Iteration: 721547645, states[0] = 12.909161, states[40]= 0.005068
Saving checkpoint... 
Iteration: 724971123, states[0] = -95.021888, states[40]= 0.000000
Saving checkpoint... 
Iteration: 730281616, states[0] = -94.929908, states[40]= 0.000000
Saving checkpoint... 
Iteration: 735185753, states[0] = -94.757240, states[40]= 0.000000
Saving checkpoint... 
Iteration: 740049830, states[0] = 12.068073, states[40]= 0.005029
Saving checkpoint... 
Iteration: 744597898, states[0] = -17.095542, states[40]= 0.001219
Saving checkpoint... 
Iteration: 748797442, states[0] = -94.945471, states[40]= 0.000000
Saving checkpoint... 
Iteration: 752940278, states[0] = -95.015645, states[40]= 0.000000
Saving checkpoint... 
Iteration: 758855091, states[0] = -94.985380, states[40]= 0.000000
Saving checkpoint... 
Iteration: 763737335, states[0] = -94.870332, states[40]= 0.000000
Saving checkpoint... 
Iteration: 767602379, states[0] = -21.372499, states[40]= 0.000888
Saving checkpoint... 
Iteration: 771727890, states[0] = -94.853839, states[40]= 0.000000
Saving checkpoint... 
Iteration: 775778999, states[0] = -94.927056, states[40]= 0.000000
Saving checkpoint... 
Iteration: 780513339, states[0] = 22.670991, states[40]= 0.026200
Saving checkpoint... 
Iteration: 784130500, states[0] = -49.417558, states[40]= 0.000031
Saving checkpoint... 
Iteration: 787683971, states[0] = -94.748914, states[40]= 0.000000
Saving checkpoint... 
Iteration: 791798461, states[0] = -94.946365, states[40]= 0.000000
Saving checkpoint... 
Iteration: 796610285, states[0] = -28.925013, states[40]= 0.000523
Saving checkpoint... 
Iteration: 801119581, states[0] = -37.970868, states[40]= 0.000176
Saving checkpoint... 
Iteration: 805693060, states[0] = -94.779725, states[40]= 0.000000
Saving checkpoint... 
Iteration: 810727730, states[0] = -94.853523, states[40]= 0.000000
Saving checkpoint... 
Iteration: 816154010, states[0] = -78.717095, states[40]= 0.000000
Saving checkpoint... 
Iteration: 820929251, states[0] = -95.012903, states[40]= 0.000000
Saving checkpoint... 
Iteration: 826479812, states[0] = -95.023277, states[40]= 0.000000
Saving checkpoint... 
Iteration: 831739264, states[0] = -94.873476, states[40]= 0.000000
Saving checkpoint... 
Iteration: 836716406, states[0] = -94.831706, states[40]= 0.000000
Saving checkpoint... 
Iteration: 839942772, states[0] = -95.016164, states[40]= 0.000000
Saving checkpoint... 
Iteration: 844646500, states[0] = -67.931783, states[40]= 0.000001
Saving checkpoint... 
Iteration: 848916720, states[0] = -95.009463, states[40]= 0.000000
Saving checkpoint... 
Iteration: 853315847, states[0] = -94.960671, states[40]= 0.000000
Saving checkpoint... 
Iteration: 859234235, states[0] = -94.865026, states[40]= 0.000000
Saving checkpoint... 
Iteration: 863831734, states[0] = -94.971786, states[40]= 0.000000
Saving checkpoint... 
Iteration: 869486566, states[0] = -95.024299, states[40]= 0.000000
Saving checkpoint... 
Iteration: 873831104, states[0] = -94.971371, states[40]= 0.000000
Saving checkpoint... 
Iteration: 878105154, states[0] = -24.020278, states[40]= 0.000755
Saving checkpoint... 
Iteration: 882457234, states[0] = -95.019209, states[40]= 0.000000
Saving checkpoint... 
Iteration: 886901663, states[0] = -95.004760, states[40]= 0.000000
Saving checkpoint... 
Iteration: 890953899, states[0] = -95.018532, states[40]= 0.000000
Saving checkpoint... 
Iteration: 895487776, states[0] = -95.024464, states[40]= 0.000000
Saving checkpoint... 
Iteration: 899250279, states[0] = -94.890497, states[40]= 0.000000
Saving checkpoint... 
Iteration: 904504328, states[0] = 31.267594, states[40]= 0.151574
Saving checkpoint... 
Iteration: 909874344, states[0] = -94.994377, states[40]= 0.000000
Saving checkpoint... 
Iteration: 915265723, states[0] = -94.911425, states[40]= 0.000000
Saving checkpoint... 
Iteration: 919471507, states[0] = -95.021835, states[40]= 0.000000
Saving checkpoint... 
Iteration: 924543565, states[0] = 14.444615, states[40]= 0.005172
Saving checkpoint... 
Iteration: 928704529, states[0] = -94.806473, states[40]= 0.000000
Saving checkpoint... 
Iteration: 932640838, states[0] = -61.044273, states[40]= 0.000004
Saving checkpoint... 
Iteration: 936940671, states[0] = -95.015622, states[40]= 0.000000
Saving checkpoint... 
Iteration: 941623868, states[0] = -42.326094, states[40]= 0.000093
Saving checkpoint... 
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Iteration: 1511167052, states[0] = -1.590663, states[40]= 0.004480
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Iteration: 1515691773, states[0] = -26.400722, states[40]= 0.000634
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Iteration: 1520052537, states[0] = -95.250206, states[40]= 0.000000
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Iteration: 1524042438, states[0] = 12.171378, states[40]= 0.005997
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Iteration: 1555268504, states[0] = -4.041383, states[40]= 0.004056
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Iteration: 1559188810, states[0] = -25.053236, states[40]= 0.000711
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Iteration: 1564157451, states[0] = -95.291183, states[40]= 0.000000
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Iteration: 1569205134, states[0] = -95.213019, states[40]= 0.000000
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Iteration: 1574163070, states[0] = -0.102667, states[40]= 0.004804
Saving checkpoint... 
Iteration: 1579511464, states[0] = 23.662273, states[40]= 0.040267
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Iteration: 1584079858, states[0] = -15.545777, states[40]= 0.001577
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Iteration: 1592013659, states[0] = -95.234504, states[40]= 0.000000
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Iteration: 1594916402, states[0] = -57.606122, states[40]= 0.000009
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Iteration: 1599416094, states[0] = -57.248698, states[40]= 0.000009
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Iteration: 1604402548, states[0] = 42.696834, states[40]= 0.086055
Saving checkpoint... 
Iteration: 1609845425, states[0] = 10.142149, states[40]= 0.005847
Saving checkpoint... 
Iteration: 1615550428, states[0] = 7.480705, states[40]= 0.005619
Saving checkpoint... 
Iteration: 1620928448, states[0] = 18.025964, states[40]= 0.007510
Saving checkpoint... 
Iteration: 1624262585, states[0] = 0.085940, states[40]= 0.004837
Saving checkpoint... 
Iteration: 1626687884, states[0] = -24.562069, states[40]= 0.000739
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Iteration: 1631477310, states[0] = -12.978278, states[40]= 0.002022
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Iteration: 1635234709, states[0] = -95.272253, states[40]= 0.000000
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Iteration: 1640399140, states[0] = -95.339498, states[40]= 0.000000
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Iteration: 1645668496, states[0] = -95.131783, states[40]= 0.000000
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Iteration: 1653794665, states[0] = -95.199806, states[40]= 0.000000
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Iteration: 1658760288, states[0] = 1.609129, states[40]= 0.005051
Saving checkpoint... 
Iteration: 1662056227, states[0] = 4.143181, states[40]= 0.005332
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Iteration: 1666451136, states[0] = -95.294671, states[40]= 0.000000
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Iteration: 1672216916, states[0] = 21.990564, states[40]= 0.015833
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Iteration: 1676359982, states[0] = -95.304961, states[40]= 0.000000
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Iteration: 1679223206, states[0] = -66.816410, states[40]= 0.000002
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Iteration: 1683838757, states[0] = -95.278794, states[40]= 0.000000
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Iteration: 1687555018, states[0] = 4.854975, states[40]= 0.005399
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Iteration: 1692436376, states[0] = -87.839334, states[40]= 0.000000
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Iteration: 1695695891, states[0] = -33.420856, states[40]= 0.000317
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Iteration: 1700003409, states[0] = -95.218970, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1703823127, states[0] = -66.715226, states[40]= 0.000002
Saving checkpoint... 
Iteration: 1709161463, states[0] = 0.821714, states[40]= 0.004946
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Iteration: 1713230620, states[0] = -95.267109, states[40]= 0.000000
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Iteration: 1717641054, states[0] = -92.664579, states[40]= 0.000000
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Iteration: 1721876564, states[0] = -95.155563, states[40]= 0.000000
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Iteration: 1726872972, states[0] = -8.558822, states[40]= 0.002999
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Iteration: 1730245256, states[0] = -94.326393, states[40]= 0.000000
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Iteration: 1733098586, states[0] = -95.339858, states[40]= 0.000000
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Iteration: 1737072455, states[0] = -8.056857, states[40]= 0.003120
Saving checkpoint... 
Iteration: 1742499729, states[0] = -37.700728, states[40]= 0.000183
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Iteration: 1747589767, states[0] = -26.690770, states[40]= 0.000624
Saving checkpoint... 
Iteration: 1753514930, states[0] = 22.554199, states[40]= 0.021144
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Iteration: 1757889482, states[0] = -95.188312, states[40]= 0.000000
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Iteration: 1763678034, states[0] = -95.323150, states[40]= 0.000000
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Iteration: 1768497515, states[0] = -95.339073, states[40]= 0.000000
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Iteration: 1772787192, states[0] = -23.861306, states[40]= 0.000779
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Iteration: 1777628546, states[0] = -74.835378, states[40]= 0.000000
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Iteration: 1782082520, states[0] = -18.712443, states[40]= 0.001177
Saving checkpoint... 
Iteration: 1787369786, states[0] = -95.315342, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1792505208, states[0] = 29.824137, states[40]= 0.125850
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Iteration: 1797776889, states[0] = -95.156435, states[40]= 0.000000
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Iteration: 1803374494, states[0] = -95.066596, states[40]= 0.000000
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Iteration: 1808435520, states[0] = -95.077905, states[40]= 0.000000
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Iteration: 1812649178, states[0] = -76.856833, states[40]= 0.000000
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Iteration: 1817200866, states[0] = -94.846957, states[40]= 0.000000
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Iteration: 1820501228, states[0] = 51.012154, states[40]= 0.042056
Saving checkpoint... 
Iteration: 1824557671, states[0] = 8.230665, states[40]= 0.004936
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Iteration: 1829426536, states[0] = -95.047448, states[40]= 0.000000
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Iteration: 1834136508, states[0] = -58.163077, states[40]= 0.000007
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Iteration: 1838241799, states[0] = -94.904872, states[40]= 0.000000
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Iteration: 1843065689, states[0] = 4.959660, states[40]= 0.004765
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Iteration: 1848297880, states[0] = -94.965628, states[40]= 0.000000
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Iteration: 1853337768, states[0] = -94.992432, states[40]= 0.000000
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Iteration: 1858645751, states[0] = -68.129181, states[40]= 0.000001
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Iteration: 1862766906, states[0] = -94.925548, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1866132533, states[0] = -52.409477, states[40]= 0.000019
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Iteration: 1870686663, states[0] = -94.771135, states[40]= 0.000000
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Iteration: 1874507782, states[0] = 24.605058, states[40]= 0.090866
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Iteration: 1878242917, states[0] = -94.887004, states[40]= 0.000000
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Iteration: 1882799571, states[0] = -94.953833, states[40]= 0.000000
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Iteration: 1887122515, states[0] = -41.285504, states[40]= 0.000109
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Iteration: 1892819380, states[0] = -94.967910, states[40]= 0.000000
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Iteration: 1896953838, states[0] = -95.022507, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1900013273, states[0] = 22.656147, states[40]= 0.026525
Saving checkpoint... 
Iteration: 1903870566, states[0] = -94.995845, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1909372032, states[0] = -94.995911, states[40]= 0.000000
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Iteration: 1914475579, states[0] = -95.024610, states[40]= 0.000000
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Iteration: 1918723026, states[0] = -94.846465, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1922568923, states[0] = 3.846350, states[40]= 0.004670
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Iteration: 1926370457, states[0] = -94.993917, states[40]= 0.000000
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Iteration: 1930165904, states[0] = -93.065722, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1935069619, states[0] = 3.518301, states[40]= 0.004645
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Iteration: 1940164949, states[0] = -92.578732, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1945475889, states[0] = -95.022976, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1951560826, states[0] = 7.573944, states[40]= 0.004876
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Iteration: 1954678732, states[0] = -94.701530, states[40]= 0.000000
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Iteration: 1959935338, states[0] = -95.014373, states[40]= 0.000000
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Iteration: 1963974053, states[0] = -95.022195, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1968607624, states[0] = -26.404523, states[40]= 0.000644
Saving checkpoint... 
Iteration: 1972568288, states[0] = 4.189346, states[40]= 0.004694
Saving checkpoint... 
Iteration: 1976163075, states[0] = -91.258632, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1980243816, states[0] = -94.880378, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1984155295, states[0] = -80.809485, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1988044029, states[0] = 14.268665, states[40]= 0.005158
Saving checkpoint... 
Iteration: 1993253424, states[0] = -94.894562, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1998213320, states[0] = -94.824837, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2001980407, states[0] = -95.022793, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2005429613, states[0] = -95.012392, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2009827737, states[0] = -94.968545, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2013544704, states[0] = 14.019074, states[40]= 0.005138
Saving checkpoint... 
Iteration: 2017956536, states[0] = -95.018440, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2023058443, states[0] = 8.600609, states[40]= 0.004912
Saving checkpoint... 
Iteration: 2028235393, states[0] = -94.866317, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2031698693, states[0] = -94.792590, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2036760837, states[0] = -94.904476, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2041584598, states[0] = -5.444729, states[40]= 0.003320
Saving checkpoint... 
Iteration: 2047116097, states[0] = -34.540375, states[40]= 0.000279
Saving checkpoint... 
Iteration: 2050610924, states[0] = -29.539819, states[40]= 0.000494
Saving checkpoint... 
Iteration: 2055849195, states[0] = -94.981432, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2060742423, states[0] = -94.877781, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2064609277, states[0] = -27.959975, states[40]= 0.000570
Saving checkpoint... 
Iteration: 2068621640, states[0] = -40.041789, states[40]= 0.000131
Saving checkpoint... 
Iteration: 2072390928, states[0] = -95.000239, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2077885698, states[0] = -94.998258, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2082612643, states[0] = -31.191751, states[40]= 0.000416
Saving checkpoint... 
Iteration: 2087265345, states[0] = -94.910187, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2092809178, states[0] = -94.954654, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2096361438, states[0] = -94.987695, states[40]= 0.000000
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.901268
 - CaMKt in component CaMK (millimolar): 0.006974
 - cass in component intracellular_ions (millimolar): 0.000074
 - nai in component intracellular_ions (millimolar): 6.462013
 - nass in component intracellular_ions (millimolar): 6.462075
 - ki in component intracellular_ions (millimolar): 145.515617
 - kss in component intracellular_ions (millimolar): 145.515596
 - cansr in component intracellular_ions (millimolar): 1.312846
 - cajsr in component intracellular_ions (millimolar): 1.274792
 - cai in component intracellular_ions (millimolar): 0.000075
 - m in component INa (dimensionless): 0.003619
 - hf in component INa (dimensionless): 0.879991
 - hs in component INa (dimensionless): 0.879985
 - j in component INa (dimensionless): 0.879952
 - hsp in component INa (dimensionless): 0.725807
 - jp in component INa (dimensionless): 0.879930
 - mL in component INaL (dimensionless): 0.000050
 - hL in component INaL (dimensionless): 0.709662
 - hLp in component INaL (dimensionless): 0.451260
 - a in component Ito (dimensionless): 0.000623
 - iF in component Ito (dimensionless): 0.999870
 - iS in component Ito (dimensionless): 0.620871
 - ap in component Ito (dimensionless): 0.000318
 - iFp in component Ito (dimensionless): 0.999870
 - iSp in component Ito (dimensionless): 0.695395
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.934179
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999883
 - jca in component ICaL (dimensionless): 0.999978
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001610
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.339244
 - xs1 in component IKs (dimensionless): 0.243115
 - xs2 in component IKs (dimensionless): 0.000088
 - xk1 in component IK1 (dimensionless): 0.997337
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
12:05:28 (75875): called boinc_finish(0)


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170541889546_ORdGradInc_k_25-Pueyo_APDR-conf_496.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170541889546_ORdGradInc_k_25-Pueyo_APDR-conf_496_0_r1101506148_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170541889546_ORdGradInc_k_25-Pueyo_APDR-conf_496_0_r1101506148_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 116.308203
     * GNaL_b in INaL: 0.006843
     * Gto_b in Ito: 0.085731
     * PCa_b in ICaL: 0.000081
     * GKr_b in IKr: 0.032955
     * GKs_b in IKs: 0.002132
     * GK1_b in IK1: 0.148638
     * Gncx_b in INaCa_i: 0.000970
     * Pnak_b in INaK: 74.755530
     * GKb_b in IKb: 0.003844
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.019184
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Loading checkpoint...
Loading iteration number...
 - Iteration number: 2096361438
Loading states...
 - states[0]: -87.000000 (Before loading)
 - states[40]: 0.000000 (Before loading)
 - states[0]: -94.987695 (After loading)
 - states[40]: 0.000000 (After loading)
Loading output...
Loading postprocessing...
Loading startTime...
Loading startAP...
Loading num AP...
Loading resultsTime...
Loading resultsAPD90...
Loading resultsAPD75...
Loading resultsAPD50...
Loading resultsAPD25...
Loading resultsAPD10...
Loading resultsTriangulation...
Loading resultsMaxV...
Loading resultsMinV...
Loading resultsMaxDiffV...
Loading resultsMinDiffV...
Copy resultsTime...
Copy resultsAPD90...
Copy resultsAPD75...
Copy resultsAPD50...
Copy resultsAPD25...
Copy resultsAPD10...
Copy resultsTriangulation...
Copy resultsMaxV...
Copy resultsMinV...
Copy resultsMaxDiffV...
Copy resultsMinDiffV...
Loading last results...
Postprocessing loaded.
Simulation loaded.
Checkpoint loaded.
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.901268
 - CaMKt in component CaMK (millimolar): 0.006974
 - cass in component intracellular_ions (millimolar): 0.000074
 - nai in component intracellular_ions (millimolar): 6.462013
 - nass in component intracellular_ions (millimolar): 6.462075
 - ki in component intracellular_ions (millimolar): 145.515617
 - kss in component intracellular_ions (millimolar): 145.515596
 - cansr in component intracellular_ions (millimolar): 1.312846
 - cajsr in component intracellular_ions (millimolar): 1.274792
 - cai in component intracellular_ions (millimolar): 0.000075
 - m in component INa (dimensionless): 0.003619
 - hf in component INa (dimensionless): 0.879991
 - hs in component INa (dimensionless): 0.879985
 - j in component INa (dimensionless): 0.879952
 - hsp in component INa (dimensionless): 0.725807
 - jp in component INa (dimensionless): 0.879930
 - mL in component INaL (dimensionless): 0.000050
 - hL in component INaL (dimensionless): 0.709662
 - hLp in component INaL (dimensionless): 0.451260
 - a in component Ito (dimensionless): 0.000623
 - iF in component Ito (dimensionless): 0.999870
 - iS in component Ito (dimensionless): 0.620871
 - ap in component Ito (dimensionless): 0.000318
 - iFp in component Ito (dimensionless): 0.999870
 - iSp in component Ito (dimensionless): 0.695395
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.934179
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999883
 - jca in component ICaL (dimensionless): 0.999978
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001610
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.339244
 - xs1 in component IKs (dimensionless): 0.243115
 - xs2 in component IKs (dimensionless): 0.000088
 - xk1 in component IK1 (dimensionless): 0.997337
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
12:09:17 (79152): called boinc_finish(0)

</stderr_txt>
]]>


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