𝕏

Task 55454739

Name HuVeMOp_20240630170044357420_ORdGradInc_k_25-Pueyo_APDR-conf_7_1
Workunit 26333341
Created 30 Jun 2024, 15:00:47 UTC
Sent 30 Jun 2024, 15:50:12 UTC
Report deadline 4 Jul 2024, 1:26:12 UTC
Received 3 Jul 2024, 20:42:27 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 220129
Run time 4 hours 13 min 2 sec
CPU time 3 hours 4 min 18 sec
Validate state Valid
Credit 63.93
Device peak FLOPS 3.26 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-apple-darwin
Peak working set size 2.21 MB
Peak swap size 4.10 GB
Peak disk usage 0.32 MB

Stderr output

<core_client_version>7.20.2</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170044357420_ORdGradInc_k_25-Pueyo_APDR-conf_7.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170044357420_ORdGradInc_k_25-Pueyo_APDR-conf_7_1_r1019588104_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170044357420_ORdGradInc_k_25-Pueyo_APDR-conf_7_1_r1019588104_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 115.012618
     * GNaL_b in INaL: 0.007246
     * Gto_b in Ito: 0.094051
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.030820
     * GKs_b in IKs: 0.002046
     * GK1_b in IK1: 0.160107
     * Gncx_b in INaCa_i: 0.000969
     * Pnak_b in INaK: 73.875987
     * GKb_b in IKb: 0.003762
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.047525
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 4350606, states[0] = -95.189632, states[40]= 0.000000
Saving checkpoint... 
Iteration: 9186167, states[0] = -94.975806, states[40]= 0.000000
Saving checkpoint... 
Iteration: 13444342, states[0] = -95.167857, states[40]= 0.000000
Saving checkpoint... 
Iteration: 16644791, states[0] = -63.822260, states[40]= 0.000003
Saving checkpoint... 
Iteration: 21902282, states[0] = -95.129235, states[40]= 0.000000
Saving checkpoint... 
Iteration: 26424105, states[0] = -95.123536, states[40]= 0.000000
Saving checkpoint... 
Iteration: 30432157, states[0] = -95.116945, states[40]= 0.000000
Saving checkpoint... 
Iteration: 34495222, states[0] = -95.120127, states[40]= 0.000000
Saving checkpoint... 
Iteration: 37968732, states[0] = -95.111083, states[40]= 0.000000
Saving checkpoint... 
Iteration: 43086802, states[0] = -4.981387, states[40]= 0.003331
Saving checkpoint... 
Iteration: 46743338, states[0] = -94.974489, states[40]= 0.000000
Saving checkpoint... 
Iteration: 51160138, states[0] = -80.347405, states[40]= 0.000000
Saving checkpoint... 
Iteration: 54771928, states[0] = -95.001698, states[40]= 0.000000
Saving checkpoint... 
Iteration: 59843678, states[0] = -95.051415, states[40]= 0.000000
Saving checkpoint... 
Iteration: 64565290, states[0] = 6.829155, states[40]= 0.004691
Saving checkpoint... 
Iteration: 69796598, states[0] = -95.014762, states[40]= 0.000000
Saving checkpoint... 
Iteration: 73722282, states[0] = -94.921797, states[40]= 0.000000
Saving checkpoint... 
Iteration: 78497383, states[0] = -95.082927, states[40]= 0.000000
Saving checkpoint... 
Iteration: 83736624, states[0] = -94.941075, states[40]= 0.000000
Saving checkpoint... 
Iteration: 87462933, states[0] = -95.075055, states[40]= 0.000000
Saving checkpoint... 
Iteration: 92269576, states[0] = -94.980979, states[40]= 0.000000
Saving checkpoint... 
Iteration: 97026823, states[0] = 20.020409, states[40]= 0.006434
Saving checkpoint... 
Iteration: 100908556, states[0] = -95.060096, states[40]= 0.000000
Saving checkpoint... 
Iteration: 104746378, states[0] = -94.949957, states[40]= 0.000000
Saving checkpoint... 
Iteration: 108124464, states[0] = -36.233987, states[40]= 0.000231
Saving checkpoint... 
Iteration: 111317557, states[0] = -95.018333, states[40]= 0.000000
Saving checkpoint... 
Iteration: 116222896, states[0] = -94.912012, states[40]= 0.000000
Saving checkpoint... 
Iteration: 121335309, states[0] = -95.027916, states[40]= 0.000000
Saving checkpoint... 
Iteration: 126639093, states[0] = -50.771331, states[40]= 0.000026
Saving checkpoint... 
Iteration: 131215876, states[0] = -94.898092, states[40]= 0.000000
Saving checkpoint... 
Iteration: 136465376, states[0] = -95.068023, states[40]= 0.000000
Saving checkpoint... 
Iteration: 139317571, states[0] = -95.015655, states[40]= 0.000000
Saving checkpoint... 
Iteration: 143855905, states[0] = -95.036594, states[40]= 0.000000
Saving checkpoint... 
Iteration: 146856309, states[0] = -95.036625, states[40]= 0.000000
Saving checkpoint... 
Iteration: 152047836, states[0] = 13.734816, states[40]= 0.004859
Saving checkpoint... 
Iteration: 157845680, states[0] = -95.031084, states[40]= 0.000000
Saving checkpoint... 
Iteration: 163319399, states[0] = -95.015808, states[40]= 0.000000
Saving checkpoint... 
Iteration: 169212989, states[0] = -94.890979, states[40]= 0.000000
Saving checkpoint... 
Iteration: 173902526, states[0] = -95.052669, states[40]= 0.000000
Saving checkpoint... 
Iteration: 178661375, states[0] = -78.874185, states[40]= 0.000000
Saving checkpoint... 
Iteration: 183166907, states[0] = -87.987836, states[40]= 0.000000
Saving checkpoint... 
Iteration: 188513260, states[0] = 22.144501, states[40]= 0.026106
Saving checkpoint... 
Iteration: 192082144, states[0] = -0.798321, states[40]= 0.004025
Saving checkpoint... 
Iteration: 197105169, states[0] = -18.523261, states[40]= 0.001070
Saving checkpoint... 
Iteration: 202546242, states[0] = 14.303104, states[40]= 0.004886
Saving checkpoint... 
Iteration: 206874857, states[0] = -95.042962, states[40]= 0.000000
Saving checkpoint... 
Iteration: 210645849, states[0] = -57.978179, states[40]= 0.000008
Saving checkpoint... 
Iteration: 214728820, states[0] = -94.917968, states[40]= 0.000000
Saving checkpoint... 
Iteration: 219363657, states[0] = -95.038380, states[40]= 0.000000
Saving checkpoint... 
Iteration: 224320314, states[0] = -95.015541, states[40]= 0.000000
Saving checkpoint... 
Iteration: 229285881, states[0] = -94.988893, states[40]= 0.000000
Saving checkpoint... 
Iteration: 233771223, states[0] = -94.974371, states[40]= 0.000000
Saving checkpoint... 
Iteration: 238065396, states[0] = 7.178085, states[40]= 0.004688
Saving checkpoint... 
Iteration: 242683962, states[0] = -94.781048, states[40]= 0.000000
Saving checkpoint... 
Iteration: 246628901, states[0] = -40.138661, states[40]= 0.000133
Saving checkpoint... 
Iteration: 250396796, states[0] = -95.050263, states[40]= 0.000000
Saving checkpoint... 
Iteration: 254234267, states[0] = -94.926448, states[40]= 0.000000
Saving checkpoint... 
Iteration: 259007203, states[0] = 24.034372, states[40]= 0.103474
Saving checkpoint... 
Iteration: 262534891, states[0] = 17.967642, states[40]= 0.005371
Saving checkpoint... 
Iteration: 267367077, states[0] = -95.039635, states[40]= 0.000000
Saving checkpoint... 
Iteration: 271964665, states[0] = -95.065678, states[40]= 0.000000
Saving checkpoint... 
Iteration: 277256206, states[0] = -94.956946, states[40]= 0.000000
Saving checkpoint... 
Iteration: 281286991, states[0] = -94.989764, states[40]= 0.000000
Saving checkpoint... 
Iteration: 285390539, states[0] = -95.048207, states[40]= 0.000000
Saving checkpoint... 
Iteration: 290039926, states[0] = 16.413245, states[40]= 0.005073
Saving checkpoint... 
Iteration: 294006623, states[0] = 24.640721, states[40]= 0.116619
Saving checkpoint... 
Iteration: 297003720, states[0] = 32.550182, states[40]= 0.149047
Saving checkpoint... 
Iteration: 301843369, states[0] = -95.028680, states[40]= 0.000000
Saving checkpoint... 
Iteration: 307498377, states[0] = -95.070323, states[40]= 0.000000
Saving checkpoint... 
Iteration: 311724728, states[0] = -94.910914, states[40]= 0.000000
Saving checkpoint... 
Iteration: 316852621, states[0] = -95.033221, states[40]= 0.000000
Saving checkpoint... 
Iteration: 320109528, states[0] = -22.405316, states[40]= 0.000849
Saving checkpoint... 
Iteration: 324895782, states[0] = -95.049838, states[40]= 0.000000
Saving checkpoint... 
Iteration: 330219322, states[0] = -94.901545, states[40]= 0.000000
Saving checkpoint... 
Iteration: 335069130, states[0] = 5.606509, states[40]= 0.004619
Saving checkpoint... 
Iteration: 340053233, states[0] = 11.842666, states[40]= 0.004802
Saving checkpoint... 
Iteration: 344785954, states[0] = -94.988755, states[40]= 0.000000
Saving checkpoint... 
Iteration: 348559322, states[0] = 9.582274, states[40]= 0.004757
Saving checkpoint... 
Iteration: 354047821, states[0] = 13.761342, states[40]= 0.004859
Saving checkpoint... 
Iteration: 358840135, states[0] = -95.026940, states[40]= 0.000000
Saving checkpoint... 
Iteration: 362698080, states[0] = -94.860420, states[40]= 0.000000
Saving checkpoint... 
Iteration: 367423855, states[0] = -95.057484, states[40]= 0.000000
Saving checkpoint... 
Iteration: 371590227, states[0] = -5.965604, states[40]= 0.003102
Saving checkpoint... 
Iteration: 374744667, states[0] = -94.941622, states[40]= 0.000000
Saving checkpoint... 
Iteration: 378947297, states[0] = -95.062504, states[40]= 0.000000
Saving checkpoint... 
Iteration: 383600838, states[0] = -14.641398, states[40]= 0.001477
Saving checkpoint... 
Iteration: 389030253, states[0] = 19.258491, states[40]= 0.005850
Saving checkpoint... 
Iteration: 392464264, states[0] = -95.065501, states[40]= 0.000000
Saving checkpoint... 
Iteration: 398019419, states[0] = 21.469328, states[40]= 0.010126
Saving checkpoint... 
Iteration: 402644052, states[0] = -55.954739, states[40]= 0.000011
Saving checkpoint... 
Iteration: 406571073, states[0] = 4.751847, states[40]= 0.004571
Saving checkpoint... 
Iteration: 409811837, states[0] = -95.009546, states[40]= 0.000000
Saving checkpoint... 
Iteration: 413480129, states[0] = -95.067893, states[40]= 0.000000
Saving checkpoint... 
Iteration: 417534429, states[0] = 18.103699, states[40]= 0.005408
Saving checkpoint... 
Iteration: 421368515, states[0] = -95.040080, states[40]= 0.000000
Saving checkpoint... 
Iteration: 426639685, states[0] = -51.191990, states[40]= 0.000024
Saving checkpoint... 
Iteration: 431830269, states[0] = -95.021383, states[40]= 0.000000
Saving checkpoint... 
Iteration: 437074391, states[0] = 3.224578, states[40]= 0.004464
Saving checkpoint... 
Iteration: 441840722, states[0] = -95.027196, states[40]= 0.000000
Saving checkpoint... 
Iteration: 445966536, states[0] = -95.065833, states[40]= 0.000000
Saving checkpoint... 
Iteration: 449755722, states[0] = -94.956201, states[40]= 0.000000
Saving checkpoint... 
Iteration: 454814442, states[0] = -95.011328, states[40]= 0.000000
Saving checkpoint... 
Iteration: 457711268, states[0] = -94.886744, states[40]= 0.000000
Saving checkpoint... 
Iteration: 461823786, states[0] = -95.017442, states[40]= 0.000000
Saving checkpoint... 
Iteration: 465421270, states[0] = -95.056795, states[40]= 0.000000
Saving checkpoint... 
Iteration: 470274112, states[0] = -94.977137, states[40]= 0.000000
Saving checkpoint... 
Iteration: 474976187, states[0] = -95.067289, states[40]= 0.000000
Saving checkpoint... 
Iteration: 479975833, states[0] = -95.067234, states[40]= 0.000000
Saving checkpoint... 
Iteration: 483900286, states[0] = -95.051103, states[40]= 0.000000
Saving checkpoint... 
Iteration: 488430759, states[0] = -95.059003, states[40]= 0.000000
Saving checkpoint... 
Iteration: 491841624, states[0] = -95.027639, states[40]= 0.000000
Saving checkpoint... 
Iteration: 496256718, states[0] = -94.957410, states[40]= 0.000000
Saving checkpoint... 
Iteration: 501349927, states[0] = -95.031811, states[40]= 0.000000
Saving checkpoint... 
Iteration: 506165903, states[0] = -86.430530, states[40]= 0.000000
Saving checkpoint... 
Iteration: 511764277, states[0] = -94.966401, states[40]= 0.000000
Saving checkpoint... 
Iteration: 516644481, states[0] = -56.430366, states[40]= 0.000010
Saving checkpoint... 
Iteration: 520246391, states[0] = -94.943918, states[40]= 0.000000
Saving checkpoint... 
Iteration: 524658688, states[0] = -74.431079, states[40]= 0.000000
Saving checkpoint... 
Iteration: 528328804, states[0] = -95.020458, states[40]= 0.000000
Saving checkpoint... 
Iteration: 531890966, states[0] = -95.048166, states[40]= 0.000000
Saving checkpoint... 
Iteration: 535873344, states[0] = -95.041912, states[40]= 0.000000
Saving checkpoint... 
Iteration: 540896566, states[0] = -95.049938, states[40]= 0.000000
Saving checkpoint... 
Iteration: 545290579, states[0] = -94.992761, states[40]= 0.000000
Saving checkpoint... 
Iteration: 548916164, states[0] = -95.055462, states[40]= 0.000000
Saving checkpoint... 
Iteration: 553625858, states[0] = -37.229945, states[40]= 0.000202
Saving checkpoint... 
Iteration: 557288372, states[0] = -94.990804, states[40]= 0.000000
Saving checkpoint... 
Iteration: 561650949, states[0] = -63.895573, states[40]= 0.000003
Saving checkpoint... 
Iteration: 566016127, states[0] = 21.867021, states[40]= 0.015466
Saving checkpoint... 
Iteration: 571544704, states[0] = 14.833195, states[40]= 0.004918
Saving checkpoint... 
Iteration: 577642096, states[0] = -53.804296, states[40]= 0.000016
Saving checkpoint... 
Iteration: 582413380, states[0] = -95.054716, states[40]= 0.000000
Saving checkpoint... 
Iteration: 585969994, states[0] = -95.066289, states[40]= 0.000000
Saving checkpoint... 
Iteration: 591431634, states[0] = -95.059133, states[40]= 0.000000
Saving checkpoint... 
Iteration: 597330164, states[0] = -95.021217, states[40]= 0.000000
Saving checkpoint... 
Iteration: 602453771, states[0] = -95.063565, states[40]= 0.000000
Saving checkpoint... 
Iteration: 606914768, states[0] = -95.055064, states[40]= 0.000000
Saving checkpoint... 
Iteration: 611432915, states[0] = -95.059404, states[40]= 0.000000
Saving checkpoint... 
Iteration: 616162522, states[0] = -80.754691, states[40]= 0.000000
Saving checkpoint... 
Iteration: 621543005, states[0] = 15.404806, states[40]= 0.004962
Saving checkpoint... 
Iteration: 625570030, states[0] = 5.214091, states[40]= 0.004598
Saving checkpoint... 
Iteration: 630384949, states[0] = -95.046086, states[40]= 0.000000
Saving checkpoint... 
Iteration: 635862644, states[0] = -95.037506, states[40]= 0.000000
Saving checkpoint... 
Iteration: 641261790, states[0] = -94.963434, states[40]= 0.000000
Saving checkpoint... 
Iteration: 646254259, states[0] = -94.954233, states[40]= 0.000000
Saving checkpoint... 
Iteration: 649903748, states[0] = -95.052015, states[40]= 0.000000
Saving checkpoint... 
Iteration: 653749222, states[0] = -94.947670, states[40]= 0.000000
Saving checkpoint... 
Iteration: 658032719, states[0] = 18.592407, states[40]= 0.005563
Saving checkpoint... 
Iteration: 662906608, states[0] = -95.052821, states[40]= 0.000000
Saving checkpoint... 
Iteration: 667239805, states[0] = -94.934470, states[40]= 0.000000
Saving checkpoint... 
Iteration: 671568829, states[0] = 5.736785, states[40]= 0.004625
Saving checkpoint... 
Iteration: 676352620, states[0] = -95.032985, states[40]= 0.000000
Saving checkpoint... 
Iteration: 682124818, states[0] = -36.255084, states[40]= 0.000231
Saving checkpoint... 
Iteration: 687149053, states[0] = -61.633198, states[40]= 0.000004
Saving checkpoint... 
Iteration: 691622570, states[0] = -34.171620, states[40]= 0.000304
Saving checkpoint... 
Iteration: 695705508, states[0] = -94.875510, states[40]= 0.000000
Saving checkpoint... 
Iteration: 700139837, states[0] = -51.355274, states[40]= 0.000023
Saving checkpoint... 
Iteration: 704621774, states[0] = -33.440253, states[40]= 0.000333
Saving checkpoint... 
Iteration: 708938980, states[0] = -95.060636, states[40]= 0.000000
Saving checkpoint... 
Iteration: 712974813, states[0] = -95.066937, states[40]= 0.000000
Saving checkpoint... 
Iteration: 717444969, states[0] = -95.061838, states[40]= 0.000000
Saving checkpoint... 
Iteration: 722466740, states[0] = -95.065691, states[40]= 0.000000
Saving checkpoint... 
Iteration: 727342904, states[0] = -95.028157, states[40]= 0.000000
Saving checkpoint... 
Iteration: 732529939, states[0] = 19.339797, states[40]= 0.005893
Saving checkpoint... 
Iteration: 736404330, states[0] = -95.052128, states[40]= 0.000000
Saving checkpoint... 
Iteration: 740978859, states[0] = -95.067506, states[40]= 0.000000
Saving checkpoint... 
Iteration: 745909549, states[0] = -95.053584, states[40]= 0.000000
Saving checkpoint... 
Iteration: 749962505, states[0] = -95.064985, states[40]= 0.000000
Saving checkpoint... 
Iteration: 755783673, states[0] = -94.986377, states[40]= 0.000000
Saving checkpoint... 
Iteration: 760682722, states[0] = -94.753824, states[40]= 0.000000
Saving checkpoint... 
Iteration: 765406907, states[0] = -95.052841, states[40]= 0.000000
Saving checkpoint... 
Iteration: 770806189, states[0] = -95.005226, states[40]= 0.000000
Saving checkpoint... 
Iteration: 775320102, states[0] = -95.014899, states[40]= 0.000000
Saving checkpoint... 
Iteration: 778357331, states[0] = -95.035087, states[40]= 0.000000
Saving checkpoint... 
Iteration: 783433337, states[0] = -95.059388, states[40]= 0.000000
Saving checkpoint... 
Iteration: 788798606, states[0] = -94.999340, states[40]= 0.000000
Saving checkpoint... 
Iteration: 792877265, states[0] = -95.043233, states[40]= 0.000000
Saving checkpoint... 
Iteration: 796862183, states[0] = -95.037207, states[40]= 0.000000
Saving checkpoint... 
Iteration: 800903080, states[0] = -95.051726, states[40]= 0.000000
Saving checkpoint... 
Iteration: 804149946, states[0] = -62.688511, states[40]= 0.000003
Saving checkpoint... 
Iteration: 808926454, states[0] = -95.057817, states[40]= 0.000000
Saving checkpoint... 
Iteration: 813083637, states[0] = -1.651369, states[40]= 0.003898
Saving checkpoint... 
Iteration: 818046707, states[0] = 14.147571, states[40]= 0.004877
Saving checkpoint... 
Iteration: 822695317, states[0] = -94.853668, states[40]= 0.000000
Saving checkpoint... 
Iteration: 827995578, states[0] = -95.069648, states[40]= 0.000000
Saving checkpoint... 
Iteration: 833357557, states[0] = -95.035154, states[40]= 0.000000
Saving checkpoint... 
Iteration: 838996358, states[0] = -95.069735, states[40]= 0.000000
Saving checkpoint... 
Iteration: 843493115, states[0] = -95.069337, states[40]= 0.000000
Saving checkpoint... 
Iteration: 848717675, states[0] = -94.898275, states[40]= 0.000000
Saving checkpoint... 
Iteration: 853008415, states[0] = 23.206881, states[40]= 0.078775
Saving checkpoint... 
Iteration: 856902331, states[0] = -95.051472, states[40]= 0.000000
Saving checkpoint... 
Iteration: 860750221, states[0] = -94.948866, states[40]= 0.000000
Saving checkpoint... 
Iteration: 864174527, states[0] = -93.883959, states[40]= 0.000000
Saving checkpoint... 
Iteration: 868493693, states[0] = -95.069392, states[40]= 0.000000
Saving checkpoint... 
Iteration: 872818251, states[0] = -95.013627, states[40]= 0.000000
Saving checkpoint... 
Iteration: 878364648, states[0] = -95.038201, states[40]= 0.000000
Saving checkpoint... 
Iteration: 881962225, states[0] = -95.064855, states[40]= 0.000000
Saving checkpoint... 
Iteration: 885163250, states[0] = -82.008968, states[40]= 0.000000
Saving checkpoint... 
Iteration: 889538317, states[0] = 16.924776, states[40]= 0.005150
Saving checkpoint... 
Iteration: 894159717, states[0] = -76.056697, states[40]= 0.000000
Saving checkpoint... 
Iteration: 899066477, states[0] = 6.733375, states[40]= 0.004671
Saving checkpoint... 
Iteration: 903514675, states[0] = 22.010764, states[40]= 0.019816
Saving checkpoint... 
Iteration: 907835016, states[0] = -95.023800, states[40]= 0.000000
Saving checkpoint... 
Iteration: 912456618, states[0] = -95.063877, states[40]= 0.000000
Saving checkpoint... 
Iteration: 916916525, states[0] = -95.055322, states[40]= 0.000000
Saving checkpoint... 
Iteration: 921514069, states[0] = 22.068689, states[40]= 0.022213
Saving checkpoint... 
Iteration: 925966643, states[0] = -95.065548, states[40]= 0.000000
Saving checkpoint... 
Iteration: 929609190, states[0] = -22.102430, states[40]= 0.000863
Saving checkpoint... 
Iteration: 933726404, states[0] = -94.913319, states[40]= 0.000000
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Iteration: 1362029348, states[0] = 19.490452, states[40]= 0.005980
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Iteration: 1403702486, states[0] = -94.869029, states[40]= 0.000000
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Iteration: 1408003054, states[0] = 36.601218, states[40]= 0.130705
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Iteration: 1411216166, states[0] = -94.895195, states[40]= 0.000000
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Iteration: 1416038985, states[0] = 16.714138, states[40]= 0.005116
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Iteration: 1421008284, states[0] = 23.275090, states[40]= 0.081206
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Iteration: 1424839862, states[0] = -95.026119, states[40]= 0.000000
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Iteration: 1430011756, states[0] = 22.319464, states[40]= 0.036113
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Iteration: 1435574174, states[0] = 3.327595, states[40]= 0.004472
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Iteration: 1441436919, states[0] = -95.059743, states[40]= 0.000000
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Iteration: 1446705562, states[0] = -94.875139, states[40]= 0.000000
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Iteration: 1451012210, states[0] = 22.262102, states[40]= 0.032650
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Iteration: 1458228738, states[0] = -94.916832, states[40]= 0.000000
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Iteration: 1462491690, states[0] = -95.068769, states[40]= 0.000000
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Iteration: 1466295977, states[0] = -94.996767, states[40]= 0.000000
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Iteration: 1469115779, states[0] = -28.001765, states[40]= 0.000594
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Iteration: 1473347076, states[0] = -95.029801, states[40]= 0.000000
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Iteration: 1479118463, states[0] = -30.423916, states[40]= 0.000472
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Iteration: 1493163744, states[0] = -82.857316, states[40]= 0.000000
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Iteration: 1498517168, states[0] = 21.754305, states[40]= 0.013255
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Iteration: 1503587554, states[0] = -95.287881, states[40]= 0.000000
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Iteration: 1507860019, states[0] = 4.749351, states[40]= 0.005115
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Iteration: 1512524588, states[0] = -95.234538, states[40]= 0.000000
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Iteration: 1518303552, states[0] = 35.070458, states[40]= 0.110101
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Iteration: 1522420901, states[0] = -95.240628, states[40]= 0.000000
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Iteration: 1525658207, states[0] = -95.007851, states[40]= 0.000000
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Iteration: 1529532835, states[0] = -69.848978, states[40]= 0.000001
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Iteration: 1535552440, states[0] = -94.574211, states[40]= 0.000000
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Iteration: 1539252298, states[0] = -95.296569, states[40]= 0.000000
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Iteration: 1548122874, states[0] = -57.545657, states[40]= 0.000009
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Iteration: 1552852058, states[0] = 8.013218, states[40]= 0.005449
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Iteration: 1556914970, states[0] = -95.256666, states[40]= 0.000000
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Iteration: 1561174837, states[0] = -95.329527, states[40]= 0.000000
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Iteration: 1565798728, states[0] = -30.687637, states[40]= 0.000444
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Iteration: 1568719905, states[0] = 21.104824, states[40]= 0.011084
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Iteration: 1572477322, states[0] = -95.185995, states[40]= 0.000000
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Iteration: 1578163406, states[0] = -95.140867, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1582821853, states[0] = 20.537864, states[40]= 0.009543
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Iteration: 1586715550, states[0] = 22.106256, states[40]= 0.018686
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Iteration: 1590914574, states[0] = 22.311279, states[40]= 0.021908
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Iteration: 1596229280, states[0] = -95.287510, states[40]= 0.000000
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Iteration: 1601226214, states[0] = -62.839089, states[40]= 0.000004
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Iteration: 1604889397, states[0] = -95.218722, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1608017002, states[0] = 21.763811, states[40]= 0.015165
Saving checkpoint... 
Iteration: 1613338518, states[0] = -95.301174, states[40]= 0.000000
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Iteration: 1617886738, states[0] = -95.348145, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1620980464, states[0] = -12.232907, states[40]= 0.002115
Saving checkpoint... 
Iteration: 1624843089, states[0] = 12.151070, states[40]= 0.005782
Saving checkpoint... 
Iteration: 1629482162, states[0] = -95.204010, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1634804756, states[0] = -37.455842, states[40]= 0.000195
Saving checkpoint... 
Iteration: 1639554424, states[0] = 6.550972, states[40]= 0.005365
Saving checkpoint... 
Iteration: 1644070006, states[0] = -3.019436, states[40]= 0.004181
Saving checkpoint... 
Iteration: 1647132337, states[0] = -71.824891, states[40]= 0.000001
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Iteration: 1650992591, states[0] = -24.783381, states[40]= 0.000738
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Iteration: 1654107799, states[0] = -95.256721, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1657552770, states[0] = 7.405498, states[40]= 0.005423
Saving checkpoint... 
Iteration: 1661098196, states[0] = -95.357307, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1665308670, states[0] = 24.091249, states[40]= 0.072486
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Iteration: 1671246115, states[0] = -95.311897, states[40]= 0.000000
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Iteration: 1676096090, states[0] = -95.356063, states[40]= 0.000000
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Iteration: 1679549482, states[0] = -94.298214, states[40]= 0.000000
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Iteration: 1683424136, states[0] = -60.324933, states[40]= 0.000006
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Iteration: 1687948710, states[0] = -94.076362, states[40]= 0.000000
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Iteration: 1691492417, states[0] = -24.623181, states[40]= 0.000747
Saving checkpoint... 
Iteration: 1696261321, states[0] = 2.706859, states[40]= 0.005046
Saving checkpoint... 
Iteration: 1701733070, states[0] = -73.049668, states[40]= 0.000001
Saving checkpoint... 
Iteration: 1705311462, states[0] = -44.926408, states[40]= 0.000067
Saving checkpoint... 
Iteration: 1710390844, states[0] = -22.997550, states[40]= 0.000838
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Iteration: 1714659260, states[0] = -95.110049, states[40]= 0.000000
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Iteration: 1720273393, states[0] = -5.730566, states[40]= 0.003592
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Iteration: 1724887645, states[0] = -95.217381, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1729313226, states[0] = -46.976452, states[40]= 0.000049
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Iteration: 1732318228, states[0] = -52.961861, states[40]= 0.000019
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Iteration: 1736562557, states[0] = -95.142914, states[40]= 0.000000
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Iteration: 1739327639, states[0] = -95.288521, states[40]= 0.000000
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Iteration: 1744673249, states[0] = -95.183164, states[40]= 0.000000
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Iteration: 1749805556, states[0] = -95.253117, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1753817854, states[0] = 21.545157, states[40]= 0.013630
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Iteration: 1758576730, states[0] = -95.341901, states[40]= 0.000000
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Iteration: 1763381088, states[0] = -95.345387, states[40]= 0.000000
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Iteration: 1766864245, states[0] = -95.152769, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1770716146, states[0] = -50.443938, states[40]= 0.000029
Saving checkpoint... 
Iteration: 1776412891, states[0] = -46.586638, states[40]= 0.000052
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Iteration: 1780670801, states[0] = -95.176456, states[40]= 0.000000
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Iteration: 1785564296, states[0] = -95.330978, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1789332331, states[0] = -71.871818, states[40]= 0.000001
Saving checkpoint... 
Iteration: 1792901941, states[0] = -34.523211, states[40]= 0.000285
Saving checkpoint... 
Iteration: 1797362624, states[0] = 1.923448, states[40]= 0.004960
Saving checkpoint... 
Iteration: 1801151525, states[0] = -72.440174, states[40]= 0.000001
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Iteration: 1805906693, states[0] = -95.110581, states[40]= 0.000000
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Iteration: 1810763304, states[0] = -95.015346, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1814164586, states[0] = -89.738415, states[40]= 0.000000
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Iteration: 1818365167, states[0] = -95.080695, states[40]= 0.000000
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Iteration: 1823223202, states[0] = -94.944707, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1828611395, states[0] = -25.870081, states[40]= 0.000697
Saving checkpoint... 
Iteration: 1832479334, states[0] = -95.095438, states[40]= 0.000000
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Iteration: 1836379928, states[0] = -95.068959, states[40]= 0.000000
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Iteration: 1840310716, states[0] = -95.030518, states[40]= 0.000000
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Iteration: 1843924982, states[0] = -95.077026, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1848104520, states[0] = -18.881572, states[40]= 0.001046
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Iteration: 1853459396, states[0] = -95.078878, states[40]= 0.000000
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Iteration: 1858180658, states[0] = -94.732188, states[40]= 0.000000
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Iteration: 1862281357, states[0] = -94.995170, states[40]= 0.000000
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Iteration: 1866705141, states[0] = -94.884306, states[40]= 0.000000
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Iteration: 1869994729, states[0] = -95.078017, states[40]= 0.000000
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Iteration: 1873343506, states[0] = -95.036019, states[40]= 0.000000
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Iteration: 1878176413, states[0] = -94.376216, states[40]= 0.000000
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Iteration: 1882788185, states[0] = -94.996049, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1886996974, states[0] = -95.074585, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1891249278, states[0] = -94.951831, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1895773573, states[0] = -94.979894, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1898839070, states[0] = -95.029199, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1903967634, states[0] = -95.068326, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1908789091, states[0] = -94.993413, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1912622272, states[0] = -34.046631, states[40]= 0.000309
Saving checkpoint... 
Iteration: 1916014158, states[0] = 22.043844, states[40]= 0.021821
Saving checkpoint... 
Iteration: 1919640808, states[0] = -52.555550, states[40]= 0.000019
Saving checkpoint... 
Iteration: 1923701111, states[0] = -94.867677, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1926734755, states[0] = -94.927717, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1930438195, states[0] = -95.061133, states[40]= 0.000000
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Iteration: 1933469609, states[0] = -95.066681, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1937165704, states[0] = -86.259031, states[40]= 0.000000
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Iteration: 1941664865, states[0] = -84.884702, states[40]= 0.000000
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Iteration: 1946739044, states[0] = -94.933412, states[40]= 0.000000
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Iteration: 1950710275, states[0] = -94.884686, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1954024072, states[0] = 20.675162, states[40]= 0.007223
Saving checkpoint... 
Iteration: 1957057467, states[0] = 10.272730, states[40]= 0.004772
Saving checkpoint... 
Iteration: 1962088242, states[0] = -4.595186, states[40]= 0.003378
Saving checkpoint... 
Iteration: 1966487055, states[0] = -95.068303, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1971317170, states[0] = -95.012599, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1974944268, states[0] = -95.061243, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1979474782, states[0] = -95.066421, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1985461590, states[0] = -95.064284, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1990732327, states[0] = -94.922443, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1995031267, states[0] = 18.988277, states[40]= 0.005721
Saving checkpoint... 
Iteration: 1999443595, states[0] = -95.060892, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2003871490, states[0] = -95.040375, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2007970310, states[0] = -95.065532, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2011136375, states[0] = -47.683748, states[40]= 0.000042
Saving checkpoint... 
Iteration: 2015975022, states[0] = -95.066207, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2020537400, states[0] = 17.209351, states[40]= 0.005201
Saving checkpoint... 
Iteration: 2024256573, states[0] = -94.956298, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2027466422, states[0] = -95.064845, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2032637639, states[0] = -49.011675, states[40]= 0.000034
Saving checkpoint... 
Iteration: 2038414882, states[0] = -95.054195, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2042969979, states[0] = -95.065365, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2046564124, states[0] = 7.697459, states[40]= 0.004707
Saving checkpoint... 
Iteration: 2051533389, states[0] = 18.403161, states[40]= 0.005498
Saving checkpoint... 
Iteration: 2057032716, states[0] = 18.593109, states[40]= 0.005563
Saving checkpoint... 
Iteration: 2061154344, states[0] = -68.201823, states[40]= 0.000001
Saving checkpoint... 
Iteration: 2065313677, states[0] = -95.009755, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2068752806, states[0] = -94.951444, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2072686093, states[0] = -94.808916, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2076775161, states[0] = -94.977164, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2080629751, states[0] = -40.960505, states[40]= 0.000118
Saving checkpoint... 
Iteration: 2085597892, states[0] = -12.070637, states[40]= 0.001877
Saving checkpoint... 
Iteration: 2090393087, states[0] = -95.047826, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2095426508, states[0] = -95.056975, states[40]= 0.000000
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.945202
 - CaMKt in component CaMK (millimolar): 0.007063
 - cass in component intracellular_ions (millimolar): 0.000073
 - nai in component intracellular_ions (millimolar): 6.486361
 - nass in component intracellular_ions (millimolar): 6.486422
 - ki in component intracellular_ions (millimolar): 145.492372
 - kss in component intracellular_ions (millimolar): 145.492351
 - cansr in component intracellular_ions (millimolar): 1.307062
 - cajsr in component intracellular_ions (millimolar): 1.268141
 - cai in component intracellular_ions (millimolar): 0.000074
 - m in component INa (dimensionless): 0.003603
 - hf in component INa (dimensionless): 0.880751
 - hs in component INa (dimensionless): 0.880746
 - j in component INa (dimensionless): 0.880717
 - hsp in component INa (dimensionless): 0.727245
 - jp in component INa (dimensionless): 0.880698
 - mL in component INaL (dimensionless): 0.000049
 - hL in component INaL (dimensionless): 0.709158
 - hLp in component INaL (dimensionless): 0.447711
 - a in component Ito (dimensionless): 0.000622
 - iF in component Ito (dimensionless): 0.999871
 - iS in component Ito (dimensionless): 0.613505
 - ap in component Ito (dimensionless): 0.000317
 - iFp in component Ito (dimensionless): 0.999871
 - iSp in component Ito (dimensionless): 0.686921
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.930019
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999865
 - jca in component ICaL (dimensionless): 0.999974
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001578
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.342124
 - xs1 in component IKs (dimensionless): 0.254703
 - xs2 in component IKs (dimensionless): 0.000087
 - xk1 in component IK1 (dimensionless): 0.997326
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
16:38:13 (77618): called boinc_finish(0)


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170044357420_ORdGradInc_k_25-Pueyo_APDR-conf_7.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170044357420_ORdGradInc_k_25-Pueyo_APDR-conf_7_1_r1019588104_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630170044357420_ORdGradInc_k_25-Pueyo_APDR-conf_7_1_r1019588104_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 115.012618
     * GNaL_b in INaL: 0.007246
     * Gto_b in Ito: 0.094051
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.030820
     * GKs_b in IKs: 0.002046
     * GK1_b in IK1: 0.160107
     * Gncx_b in INaCa_i: 0.000969
     * Pnak_b in INaK: 73.875987
     * GKb_b in IKb: 0.003762
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.047525
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Loading checkpoint...
Loading iteration number...
 - Iteration number: 2095426508
Loading states...
 - states[0]: -87.000000 (Before loading)
 - states[40]: 0.000000 (Before loading)
 - states[0]: -95.056975 (After loading)
 - states[40]: 0.000000 (After loading)
Loading output...
Loading postprocessing...
Loading startTime...
Loading startAP...
Loading num AP...
Loading resultsTime...
Loading resultsAPD90...
Loading resultsAPD75...
Loading resultsAPD50...
Loading resultsAPD25...
Loading resultsAPD10...
Loading resultsTriangulation...
Loading resultsMaxV...
Loading resultsMinV...
Loading resultsMaxDiffV...
Loading resultsMinDiffV...
Copy resultsTime...
Copy resultsAPD90...
Copy resultsAPD75...
Copy resultsAPD50...
Copy resultsAPD25...
Copy resultsAPD10...
Copy resultsTriangulation...
Copy resultsMaxV...
Copy resultsMinV...
Copy resultsMaxDiffV...
Copy resultsMinDiffV...
Loading last results...
Postprocessing loaded.
Simulation loaded.
Checkpoint loaded.
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.945202
 - CaMKt in component CaMK (millimolar): 0.007063
 - cass in component intracellular_ions (millimolar): 0.000073
 - nai in component intracellular_ions (millimolar): 6.486361
 - nass in component intracellular_ions (millimolar): 6.486422
 - ki in component intracellular_ions (millimolar): 145.492372
 - kss in component intracellular_ions (millimolar): 145.492351
 - cansr in component intracellular_ions (millimolar): 1.307062
 - cajsr in component intracellular_ions (millimolar): 1.268141
 - cai in component intracellular_ions (millimolar): 0.000074
 - m in component INa (dimensionless): 0.003603
 - hf in component INa (dimensionless): 0.880751
 - hs in component INa (dimensionless): 0.880746
 - j in component INa (dimensionless): 0.880717
 - hsp in component INa (dimensionless): 0.727245
 - jp in component INa (dimensionless): 0.880698
 - mL in component INaL (dimensionless): 0.000049
 - hL in component INaL (dimensionless): 0.709158
 - hLp in component INaL (dimensionless): 0.447711
 - a in component Ito (dimensionless): 0.000622
 - iF in component Ito (dimensionless): 0.999871
 - iS in component Ito (dimensionless): 0.613505
 - ap in component Ito (dimensionless): 0.000317
 - iFp in component Ito (dimensionless): 0.999871
 - iSp in component Ito (dimensionless): 0.686921
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.930019
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999865
 - jca in component ICaL (dimensionless): 0.999974
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001578
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.342124
 - xs1 in component IKs (dimensionless): 0.254703
 - xs2 in component IKs (dimensionless): 0.000087
 - xk1 in component IK1 (dimensionless): 0.997326
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
16:42:16 (80935): called boinc_finish(0)

</stderr_txt>
]]>


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