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Results of the last simulations and next steps // Resultados de las últimas simulaciones y siguientes pasos

Message boards : News : Results of the last simulations and next steps // Resultados de las últimas simulaciones y siguientes pasos
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Profile Jesús Carro
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Message 2016 - Posted: 17 Feb 2023, 15:04:43 UTC

Dear volunteers,

I have both good and bad news to share with you regarding our recent progress. First, the good news: thanks to the results you've sent in, we have been able to identify the problem with the marker and gain a better understanding of what was happening. Additionally, it turns out that we won't need to increase the number of simulations per iteration, which is good news (for us).

However, there is also some bad news to report. We've discovered that the behavior of the model with this marker is highly non-linear, which means that it cannot be effectively addressed within the framework of our current approximation. While this could be disappointing, we can assume this limitation in the model, as it was measured experimentally under unrealistic conditions.

Once we've fine-tuned the model, we will determine whether this non-linear behavior persists, or whether it disappears with the changes we've made. If the issue does persist, we'll need to address it in the next phase of our work, which means there may be more work to come for some of you. We'll keep you updated on our progress.

We're grateful for your continued efforts and support.

Best regards,
Jesus.

===========================================

Estimados voluntarios:
Tengo noticias buenas y malas que compartir con vosotros sobre nuestro progreso reciente. Primero, las buenas noticias: gracias a los resultados que habéis enviado, hemos logrado identificar el problema con el marcador y obtener una mejor comprensión de lo que estaba sucediendo. Además, resulta que no necesitaremos aumentar el número de simulaciones por iteración, lo cual es una buena noticia (para nosotros).

Sin embargo, también hay malas noticias que reportar. Hemos descubierto que el comportamiento del modelo con este marcador es altamente no lineal, lo que significa que no puede ser abordado de manera efectiva dentro del marco de nuestra aproximación actual. Si bien esto puede ser decepcionante, podemos asumir esta limitación en el modelo, ya que se midió experimentalmente en condiciones poco realistas.

Una vez que hayamos ajustado el modelo, determinaremos si este comportamiento no lineal persiste o si desaparece con los cambios que hemos realizado. Si el problema persiste, tendremos que abordarlo en la siguiente fase de nuestro trabajo, lo que significa que puede haber más trabajo por hacer para algunos de ustedes. Os mantendremos informados sobre nuestro progreso

Muchas gracias por vuestro esfuerzo y apoyo continuo.

Atentamente,
Jesús.
Jesús Carro
Universidad San Jorge
@InSilicoHeart
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Message 2017 - Posted: 17 Feb 2023, 18:52:56 UTC - in response to Message 2016.  

Jesus, could you elaborate on the phrase "which means there may be more work to come for some of you" in the next phase of our work?
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Profile Jesús Carro
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Message 2022 - Posted: 20 Feb 2023, 12:06:10 UTC - in response to Message 2017.  

Hi TLD,
In the project we are trying to improve a model of human ventricular cells. We know now that one of the characteristics will not be included in this version, so we will need you for the next improvement of the model. This, in addition to the other subprojects that we have not yet started. In short, we will continue needing you.

Best,
Jesús
Jesús Carro
Universidad San Jorge
@InSilicoHeart
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Message boards : News : Results of the last simulations and next steps // Resultados de las últimas simulaciones y siguientes pasos