𝕏

Task 56096685

Name HuVeMOp_20240704223722441064_ORdGradInc_k_27-Drouin_EPI_5000-conf_308_1
Workunit 26640016
Created 4 Jul 2024, 20:42:08 UTC
Sent 4 Jul 2024, 22:52:43 UTC
Report deadline 7 Jul 2024, 22:52:43 UTC
Received 5 Jul 2024, 22:43:35 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 240530
Run time 2 hours 19 min 46 sec
CPU time 1 hours 52 min 39 sec
Validate state Valid
Credit 44.38
Device peak FLOPS 3.77 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-apple-darwin
Peak working set size 2.04 MB
Peak swap size 32.85 GB
Peak disk usage 0.04 MB

Stderr output

<core_client_version>8.0.2</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704223722441064_ORdGradInc_k_27-Drouin_EPI_5000-conf_308.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704223722441064_ORdGradInc_k_27-Drouin_EPI_5000-conf_308_1_r499255145_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704223722441064_ORdGradInc_k_27-Drouin_EPI_5000-conf_308_1_r499255145_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 3000000.000000
 - dt: 0.002000
 - Constants to change: 19
     * GNa in INa: 104.043508
     * GNaL_b in INaL: 0.005869
     * Gto_b in Ito: 0.084127
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.031720
     * GKs_b in IKs: 0.001932
     * GK1_b in IK1: 0.164263
     * Gncx_b in INaCa_i: 0.000967
     * Pnak_b in INaK: 70.407770
     * GKb_b in IKb: 0.003799
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.032204
     * celltype in environment: 1.000000
     * nCL_0 in membrane: 600.000000
     * CL_0 in membrane: 5000.000000
     * cao in extracellular: 2.700000
     * ko in extracellular: 4.000000
     * nao in extracellular: 150.800000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 6131072, states[0] = -94.384222, states[40]= 0.000000
Saving checkpoint... 
Iteration: 12243980, states[0] = -94.313723, states[40]= 0.000000
Saving checkpoint... 
Iteration: 18407292, states[0] = -94.297564, states[40]= 0.000000
Saving checkpoint... 
Iteration: 22798770, states[0] = -94.059957, states[40]= 0.000000
Saving checkpoint... 
Iteration: 28251760, states[0] = -94.270939, states[40]= 0.000000
Saving checkpoint... 
Iteration: 33127634, states[0] = -94.261619, states[40]= 0.000000
Saving checkpoint... 
Iteration: 38660558, states[0] = -94.240913, states[40]= 0.000000
Saving checkpoint... 
Iteration: 48044613, states[0] = -94.243064, states[40]= 0.000000
Saving checkpoint... 
Iteration: 57221721, states[0] = -94.213390, states[40]= 0.000000
Saving checkpoint... 
Iteration: 66211055, states[0] = -94.234038, states[40]= 0.000000
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Iteration: 74239194, states[0] = -94.222461, states[40]= 0.000000
Saving checkpoint... 
Iteration: 83372186, states[0] = -94.251087, states[40]= 0.000000
Saving checkpoint... 
Iteration: 92674383, states[0] = -71.307149, states[40]= 0.000006
Saving checkpoint... 
Iteration: 101746841, states[0] = -94.228019, states[40]= 0.000000
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Iteration: 108003185, states[0] = -94.243542, states[40]= 0.000000
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Iteration: 114688667, states[0] = -94.223768, states[40]= 0.000000
Saving checkpoint... 
Iteration: 119707086, states[0] = -94.224186, states[40]= 0.000000
Saving checkpoint... 
Iteration: 125100717, states[0] = 4.330061, states[40]= 0.000100
Saving checkpoint... 
Iteration: 130684997, states[0] = -94.263666, states[40]= 0.000000
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Iteration: 135343202, states[0] = -94.123023, states[40]= 0.000000
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Iteration: 140820997, states[0] = -94.261230, states[40]= 0.000000
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Iteration: 146815432, states[0] = -94.231633, states[40]= 0.000000
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Iteration: 152077988, states[0] = -94.228148, states[40]= 0.000000
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Iteration: 156395583, states[0] = -94.241054, states[40]= 0.000000
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Iteration: 164764292, states[0] = -94.226563, states[40]= 0.000000
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Iteration: 173407237, states[0] = -94.259072, states[40]= 0.000000
Saving checkpoint... 
Iteration: 182540789, states[0] = 26.417740, states[40]= 0.000000
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Iteration: 188055912, states[0] = -94.258938, states[40]= 0.000000
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Iteration: 193444417, states[0] = -94.257800, states[40]= 0.000000
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Iteration: 198421092, states[0] = -94.258821, states[40]= 0.000000
Saving checkpoint... 
Iteration: 205300318, states[0] = -94.031892, states[40]= 0.000000
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Iteration: 214611047, states[0] = -94.228850, states[40]= 0.000000
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Iteration: 223555639, states[0] = -94.253307, states[40]= 0.000000
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Iteration: 230973517, states[0] = -94.256650, states[40]= 0.000000
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Iteration: 236456612, states[0] = -94.240328, states[40]= 0.000000
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Iteration: 242238850, states[0] = -94.227377, states[40]= 0.000000
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Iteration: 249743565, states[0] = -94.227291, states[40]= 0.000000
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Iteration: 259098471, states[0] = -94.236916, states[40]= 0.000000
Saving checkpoint... 
Iteration: 267796558, states[0] = -94.021037, states[40]= 0.000000
Saving checkpoint... 
Iteration: 274001745, states[0] = -94.238996, states[40]= 0.000000
Saving checkpoint... 
Iteration: 279712483, states[0] = -94.227409, states[40]= 0.000000
Saving checkpoint... 
Iteration: 286054715, states[0] = -94.252989, states[40]= 0.000000
Saving checkpoint... 
Iteration: 291360898, states[0] = -94.242528, states[40]= 0.000000
Saving checkpoint... 
Iteration: 296730271, states[0] = -94.234030, states[40]= 0.000000
Saving checkpoint... 
Iteration: 302447295, states[0] = -94.225031, states[40]= 0.000000
Saving checkpoint... 
Iteration: 309371248, states[0] = -94.231549, states[40]= 0.000000
Saving checkpoint... 
Iteration: 315220269, states[0] = -93.662876, states[40]= 0.000000
Saving checkpoint... 
Iteration: 320162015, states[0] = -57.084520, states[40]= 0.000041
Saving checkpoint... 
Iteration: 325469341, states[0] = -94.236653, states[40]= 0.000000
Saving checkpoint... 
Iteration: 331634416, states[0] = -94.235570, states[40]= 0.000000
Saving checkpoint... 
Iteration: 337431884, states[0] = -94.224844, states[40]= 0.000000
Saving checkpoint... 
Iteration: 342638737, states[0] = -30.598384, states[40]= 0.000449
Saving checkpoint... 
Iteration: 349982927, states[0] = -94.224314, states[40]= 0.000000
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Iteration: 359308221, states[0] = -94.232104, states[40]= 0.000000
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Iteration: 368587076, states[0] = -94.250978, states[40]= 0.000000
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Iteration: 375857504, states[0] = -94.260343, states[40]= 0.000000
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Iteration: 381636564, states[0] = -94.235059, states[40]= 0.000000
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Iteration: 387770772, states[0] = -93.932279, states[40]= 0.000000
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Iteration: 393949678, states[0] = -94.239204, states[40]= 0.000000
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Iteration: 399079295, states[0] = -94.236100, states[40]= 0.000000
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Iteration: 408226667, states[0] = -94.264229, states[40]= 0.000000
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Iteration: 417799140, states[0] = -94.027050, states[40]= 0.000000
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Iteration: 425837941, states[0] = -94.260644, states[40]= 0.000000
Saving checkpoint... 
Iteration: 431600272, states[0] = -94.235340, states[40]= 0.000000
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Iteration: 436248379, states[0] = -94.244604, states[40]= 0.000000
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Iteration: 441439101, states[0] = -94.239024, states[40]= 0.000000
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Iteration: 446430163, states[0] = -94.239208, states[40]= 0.000000
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Iteration: 454544965, states[0] = -94.227745, states[40]= 0.000000
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Iteration: 463702386, states[0] = -94.245874, states[40]= 0.000000
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Iteration: 472775987, states[0] = -93.951452, states[40]= 0.000000
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Iteration: 482041441, states[0] = -94.227528, states[40]= 0.000000
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Iteration: 491287681, states[0] = -94.242834, states[40]= 0.000000
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Iteration: 500412617, states[0] = -94.203027, states[40]= 0.000000
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Iteration: 509677070, states[0] = -94.225654, states[40]= 0.000000
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Iteration: 518908817, states[0] = -94.239081, states[40]= 0.000000
Saving checkpoint... 
Iteration: 527904282, states[0] = -94.196106, states[40]= 0.000000
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Iteration: 534749695, states[0] = -94.224648, states[40]= 0.000000
Saving checkpoint... 
Iteration: 543260267, states[0] = -94.262174, states[40]= 0.000000
Saving checkpoint... 
Iteration: 551891921, states[0] = -94.228943, states[40]= 0.000000
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Iteration: 560855858, states[0] = -94.258651, states[40]= 0.000000
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Iteration: 570572413, states[0] = -94.258096, states[40]= 0.000000
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Iteration: 579693194, states[0] = -94.224809, states[40]= 0.000000
Saving checkpoint... 
Iteration: 587055733, states[0] = -94.226342, states[40]= 0.000000
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Iteration: 592871546, states[0] = -94.162372, states[40]= 0.000000
Saving checkpoint... 
Iteration: 598154420, states[0] = -94.262566, states[40]= 0.000000
Saving checkpoint... 
Iteration: 604591669, states[0] = -94.225730, states[40]= 0.000000
Saving checkpoint... 
Iteration: 612198756, states[0] = -94.224437, states[40]= 0.000000
Saving checkpoint... 
Iteration: 620656336, states[0] = -94.262386, states[40]= 0.000000
Saving checkpoint... 
Iteration: 629844033, states[0] = -94.222827, states[40]= 0.000000
Saving checkpoint... 
Iteration: 638864949, states[0] = -94.239138, states[40]= 0.000000
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Iteration: 647905073, states[0] = -94.195615, states[40]= 0.000000
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Iteration: 656673429, states[0] = -94.231699, states[40]= 0.000000
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Iteration: 665854465, states[0] = -94.257703, states[40]= 0.000000
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Iteration: 675306911, states[0] = -94.045431, states[40]= 0.000000
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Iteration: 684174597, states[0] = -94.231413, states[40]= 0.000000
Saving checkpoint... 
Iteration: 693662002, states[0] = -94.245090, states[40]= 0.000000
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Iteration: 702965042, states[0] = -94.231294, states[40]= 0.000000
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Iteration: 710685549, states[0] = -94.261754, states[40]= 0.000000
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Iteration: 716539596, states[0] = -94.233953, states[40]= 0.000000
Saving checkpoint... 
Iteration: 721435147, states[0] = -94.236450, states[40]= 0.000000
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Iteration: 726168266, states[0] = -94.244557, states[40]= 0.000000
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Iteration: 732409646, states[0] = -94.221265, states[40]= 0.000000
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Iteration: 738411353, states[0] = -94.254666, states[40]= 0.000000
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Iteration: 744644670, states[0] = -94.223769, states[40]= 0.000000
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Iteration: 749996653, states[0] = -94.220390, states[40]= 0.000000
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Iteration: 757854884, states[0] = -94.138590, states[40]= 0.000000
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Iteration: 766264404, states[0] = -94.240938, states[40]= 0.000000
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Iteration: 775793999, states[0] = -94.258915, states[40]= 0.000000
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Iteration: 784638472, states[0] = -94.223458, states[40]= 0.000000
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Iteration: 792995399, states[0] = -94.241256, states[40]= 0.000000
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Iteration: 802114132, states[0] = -94.223574, states[40]= 0.000000
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Iteration: 810931303, states[0] = -94.253133, states[40]= 0.000000
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Iteration: 820243749, states[0] = -93.802064, states[40]= 0.000000
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Iteration: 829628060, states[0] = -94.223147, states[40]= 0.000000
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Iteration: 838770458, states[0] = -94.240053, states[40]= 0.000000
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Iteration: 847721565, states[0] = -93.666437, states[40]= 0.000000
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Iteration: 854783594, states[0] = -94.221248, states[40]= 0.000000
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Iteration: 861123432, states[0] = -94.244902, states[40]= 0.000000
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Iteration: 865663916, states[0] = -94.260161, states[40]= 0.000000
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Iteration: 870594002, states[0] = -94.257241, states[40]= 0.000000
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Iteration: 876477274, states[0] = -94.233905, states[40]= 0.000000
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Iteration: 880772385, states[0] = -94.258604, states[40]= 0.000000
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Iteration: 886508276, states[0] = -94.233059, states[40]= 0.000000
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Iteration: 892516275, states[0] = 23.602957, states[40]= 0.000000
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Iteration: 897630410, states[0] = -21.851264, states[40]= 0.000315
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Iteration: 902031976, states[0] = -94.223631, states[40]= 0.000000
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Iteration: 906947432, states[0] = -94.224730, states[40]= 0.000000
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Iteration: 911891173, states[0] = -94.225509, states[40]= 0.000000
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Iteration: 917412602, states[0] = -94.219469, states[40]= 0.000000
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Iteration: 922818901, states[0] = -94.071687, states[40]= 0.000000
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Iteration: 928372990, states[0] = -94.254447, states[40]= 0.000000
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Iteration: 934366952, states[0] = -94.225665, states[40]= 0.000000
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Iteration: 939264595, states[0] = -94.227311, states[40]= 0.000000
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Iteration: 943366921, states[0] = -94.254553, states[40]= 0.000000
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Iteration: 948372219, states[0] = -94.254288, states[40]= 0.000000
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Iteration: 954274709, states[0] = -94.226991, states[40]= 0.000000
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Iteration: 959368714, states[0] = -94.225399, states[40]= 0.000000
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Iteration: 966182484, states[0] = -94.241762, states[40]= 0.000000
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Iteration: 970563931, states[0] = -94.253293, states[40]= 0.000000
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Iteration: 975094469, states[0] = 7.815367, states[40]= 0.000054
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Iteration: 980212658, states[0] = -93.602604, states[40]= 0.000000
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Iteration: 985719949, states[0] = -94.258836, states[40]= 0.000000
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Iteration: 989165021, states[0] = -94.228684, states[40]= 0.000000
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Iteration: 993699830, states[0] = -94.240898, states[40]= 0.000000
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Iteration: 998654909, states[0] = -94.242432, states[40]= 0.000000
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Iteration: 1003700484, states[0] = -94.240781, states[40]= 0.000000
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Iteration: 1007873804, states[0] = -94.161089, states[40]= 0.000000
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Iteration: 1011170706, states[0] = -94.241748, states[40]= 0.000000
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Iteration: 1024114319, states[0] = -94.229380, states[40]= 0.000000
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Iteration: 1028189252, states[0] = -94.258723, states[40]= 0.000000
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Iteration: 1034629556, states[0] = -94.221168, states[40]= 0.000000
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Iteration: 1039266929, states[0] = -94.226315, states[40]= 0.000000
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Iteration: 1043665908, states[0] = -94.241609, states[40]= 0.000000
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Iteration: 1048499732, states[0] = -94.247997, states[40]= 0.000000
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Iteration: 1052722805, states[0] = -93.672748, states[40]= 0.000000
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Iteration: 1058129342, states[0] = -94.257474, states[40]= 0.000000
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Iteration: 1063654648, states[0] = -94.241823, states[40]= 0.000000
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Iteration: 1079275009, states[0] = -94.225793, states[40]= 0.000000
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Iteration: 1083809199, states[0] = -94.236516, states[40]= 0.000000
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Iteration: 1088887672, states[0] = -94.234208, states[40]= 0.000000
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Iteration: 1094000791, states[0] = -94.231256, states[40]= 0.000000
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Iteration: 1098010125, states[0] = -94.242359, states[40]= 0.000000
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Iteration: 1103985616, states[0] = -94.231528, states[40]= 0.000000
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Iteration: 1108983480, states[0] = -94.231532, states[40]= 0.000000
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Iteration: 1114034736, states[0] = -94.230268, states[40]= 0.000000
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Iteration: 1118165126, states[0] = -94.257770, states[40]= 0.000000
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Iteration: 1124999851, states[0] = -94.216777, states[40]= 0.000000
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Iteration: 1130398230, states[0] = -94.185100, states[40]= 0.000000
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Iteration: 1135471172, states[0] = -94.229669, states[40]= 0.000000
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Iteration: 1141385878, states[0] = -94.233756, states[40]= 0.000000
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Iteration: 1147665898, states[0] = -61.554728, states[40]= 0.000022
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Iteration: 1153816115, states[0] = -94.235639, states[40]= 0.000000
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Iteration: 1159180759, states[0] = -94.226754, states[40]= 0.000000
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Iteration: 1163772184, states[0] = -94.236894, states[40]= 0.000000
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Iteration: 1169810706, states[0] = -94.217972, states[40]= 0.000000
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Iteration: 1174425801, states[0] = -94.222484, states[40]= 0.000000
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Iteration: 1179928248, states[0] = -94.216827, states[40]= 0.000000
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Iteration: 1186470393, states[0] = -94.231113, states[40]= 0.000000
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Iteration: 1191381486, states[0] = -94.233398, states[40]= 0.000000
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Iteration: 1198290777, states[0] = -94.254994, states[40]= 0.000000
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Iteration: 1207839161, states[0] = -94.109043, states[40]= 0.000000
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Iteration: 1217336249, states[0] = -94.217278, states[40]= 0.000000
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Iteration: 1225602067, states[0] = -94.254443, states[40]= 0.000000
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Iteration: 1230926499, states[0] = -94.249328, states[40]= 0.000000
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Iteration: 1236905478, states[0] = -94.222186, states[40]= 0.000000
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Iteration: 1242507320, states[0] = 18.508824, states[40]= 0.000000
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Iteration: 1250598737, states[0] = -94.253972, states[40]= 0.000000
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Iteration: 1260017313, states[0] = 23.934734, states[40]= 0.000000
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Iteration: 1268963547, states[0] = -94.230495, states[40]= 0.000000
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Iteration: 1274975910, states[0] = -94.215529, states[40]= 0.000000
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Iteration: 1281924216, states[0] = -94.221480, states[40]= 0.000000
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Iteration: 1289988983, states[0] = -94.215283, states[40]= 0.000000
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Iteration: 1298982192, states[0] = -94.229747, states[40]= 0.000000
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Iteration: 1306265322, states[0] = -94.235751, states[40]= 0.000000
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Iteration: 1311439376, states[0] = -94.230705, states[40]= 0.000000
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Iteration: 1318184838, states[0] = -94.255966, states[40]= 0.000000
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Iteration: 1326885697, states[0] = -94.221625, states[40]= 0.000000
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Iteration: 1335688319, states[0] = -94.255796, states[40]= 0.000000
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Iteration: 1342967978, states[0] = -94.226407, states[40]= 0.000000
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Iteration: 1349260612, states[0] = -94.223463, states[40]= 0.000000
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Iteration: 1354970353, states[0] = -94.214809, states[40]= 0.000000
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Iteration: 1360122617, states[0] = -13.678141, states[40]= 0.000264
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Iteration: 1366262955, states[0] = -94.235254, states[40]= 0.000000
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Iteration: 1372096302, states[0] = -94.218335, states[40]= 0.000000
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Iteration: 1379346871, states[0] = -94.221730, states[40]= 0.000000
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Iteration: 1388016292, states[0] = -94.241073, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1396860000, states[0] = -94.221355, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1405706751, states[0] = -94.255011, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1414775039, states[0] = -94.215976, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1423732161, states[0] = -94.235706, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1430433952, states[0] = -94.208604, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1436557697, states[0] = -94.226665, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1442389569, states[0] = -94.214647, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1449114499, states[0] = -94.225315, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1453368234, states[0] = -94.249637, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1458706111, states[0] = -94.236245, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1463766986, states[0] = -94.234192, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1472855665, states[0] = -94.132863, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1482019736, states[0] = -94.218244, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1491000583, states[0] = -94.243739, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1499937350, states[0] = -94.213689, states[40]= 0.000000
Total time: 3000000.000000
State Variables:
 - v in component membrane (millivolt): -94.089161
 - CaMKt in component CaMK (millimolar): 0.001697
 - cass in component intracellular_ions (millimolar): 0.000101
 - nai in component intracellular_ions (millimolar): 7.096540
 - nass in component intracellular_ions (millimolar): 7.096676
 - ki in component intracellular_ions (millimolar): 144.602688
 - kss in component intracellular_ions (millimolar): 144.602674
 - cansr in component intracellular_ions (millimolar): 2.392941
 - cajsr in component intracellular_ions (millimolar): 2.393287
 - cai in component intracellular_ions (millimolar): 0.000105
 - m in component INa (dimensionless): 0.003928
 - hf in component INa (dimensionless): 0.865167
 - hs in component INa (dimensionless): 0.865168
 - j in component INa (dimensionless): 0.865169
 - hsp in component INa (dimensionless): 0.698500
 - jp in component INa (dimensionless): 0.865170
 - mL in component INaL (dimensionless): 0.000058
 - hL in component INaL (dimensionless): 0.707227
 - hLp in component INaL (dimensionless): 0.513463
 - a in component Ito (dimensionless): 0.000659
 - iF in component Ito (dimensionless): 0.999850
 - iS in component Ito (dimensionless): 0.999850
 - ap in component Ito (dimensionless): 0.000336
 - iFp in component Ito (dimensionless): 0.999850
 - iSp in component Ito (dimensionless): 0.999850
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.998801
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 1.000000
 - jca in component ICaL (dimensionless): 1.000000
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.005290
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.001782
 - xs1 in component IKs (dimensionless): 0.023514
 - xs2 in component IKs (dimensionless): 0.000096
 - xk1 in component IK1 (dimensionless): 0.997543
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
18:30:59 (45704): called boinc_finish(0)

</stderr_txt>
]]>


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