𝕏

Task 56081052

Name HuVeMOp_20240704204347457747_ORdGradInc_k_27-TESZT-conf_894_0
Workunit 26632768
Created 4 Jul 2024, 18:56:56 UTC
Sent 4 Jul 2024, 20:44:16 UTC
Report deadline 7 Jul 2024, 20:44:16 UTC
Received 6 Jul 2024, 18:02:19 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 240889
Run time 2 hours 50 min 59 sec
CPU time 2 hours 46 min 43 sec
Validate state Valid
Credit 45.25
Device peak FLOPS 2.74 GFLOPS
Application version Human ventricular cell models optimization v0.02
aarch64-unknown-linux-gnu
Peak working set size 2.23 MB
Peak swap size 11.14 MB
Peak disk usage 0.34 MB

Stderr output

<core_client_version>7.16.16</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704204347457747_ORdGradInc_k_27-TESZT-conf_894.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704204347457747_ORdGradInc_k_27-TESZT-conf_894_0_r1268465767_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704204347457747_ORdGradInc_k_27-TESZT-conf_894_0_r1268465767_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 3000000.000000
 - dt: 0.002000
 - Constants to change: 17
     * GNa in INa: 104.175524
     * GNaL_b in INaL: 0.005732
     * Gto_b in Ito: 0.084246
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.031975
     * GKs_b in IKs: 0.001923
     * GK1_b in IK1: 0.163984
     * Gncx_b in INaCa_i: 0.000966
     * Pnak_b in INaK: 70.444278
     * GKb_b in IKb: 0.003805
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.032532
     * celltype in environment: 0.000000
     * cao in extracellular: 1.800000
     * ko in extracellular: 4.000000
     * nao in extracellular: 135.000000
Starting output configuration...
Output starts at iteration 1499500000.
Num states to save: 1.
Num rates to save: 0.
Num algebraics to save: 0.
Saving checkpoint... 
Iteration: 9327112, states[0] = -94.891746, states[40]= 0.000000
Saving checkpoint... 
Iteration: 18557698, states[0] = 13.957784, states[40]= 0.003882
Saving checkpoint... 
Iteration: 27902686, states[0] = -94.884312, states[40]= 0.000000
Saving checkpoint... 
Iteration: 37254737, states[0] = -94.691890, states[40]= 0.000000
Saving checkpoint... 
Iteration: 46741650, states[0] = -94.651684, states[40]= 0.000000
Saving checkpoint... 
Iteration: 56031585, states[0] = 24.129258, states[40]= 0.001773
Saving checkpoint... 
Iteration: 65399982, states[0] = -94.867875, states[40]= 0.000000
Saving checkpoint... 
Iteration: 74782742, states[0] = -94.742832, states[40]= 0.000000
Saving checkpoint... 
Iteration: 84088158, states[0] = -2.272058, states[40]= 0.004308
Saving checkpoint... 
Iteration: 93244642, states[0] = -94.653914, states[40]= 0.000000
Saving checkpoint... 
Iteration: 102643513, states[0] = -56.382482, states[40]= 0.000033
Saving checkpoint... 
Iteration: 111919722, states[0] = -94.874714, states[40]= 0.000000
Saving checkpoint... 
Iteration: 121216415, states[0] = -94.560236, states[40]= 0.000000
Saving checkpoint... 
Iteration: 130595156, states[0] = -8.088906, states[40]= 0.003126
Saving checkpoint... 
Iteration: 139844778, states[0] = -94.824127, states[40]= 0.000000
Saving checkpoint... 
Iteration: 149281393, states[0] = -94.737657, states[40]= 0.000000
Saving checkpoint... 
Iteration: 158553375, states[0] = 16.153853, states[40]= 0.003220
Saving checkpoint... 
Iteration: 168025117, states[0] = 26.036960, states[40]= 0.001764
Saving checkpoint... 
Iteration: 177122073, states[0] = -34.278717, states[40]= 0.000687
Saving checkpoint... 
Iteration: 186338257, states[0] = -94.817220, states[40]= 0.000000
Saving checkpoint... 
Iteration: 195349551, states[0] = -94.828066, states[40]= 0.000000
Saving checkpoint... 
Iteration: 204547001, states[0] = 18.674438, states[40]= 0.002714
Saving checkpoint... 
Iteration: 213824572, states[0] = -94.802007, states[40]= 0.000000
Saving checkpoint... 
Iteration: 223012591, states[0] = 27.798693, states[40]= 0.020937
Saving checkpoint... 
Iteration: 232452314, states[0] = -94.885766, states[40]= 0.000000
Saving checkpoint... 
Iteration: 241536033, states[0] = 22.700828, states[40]= 0.001991
Saving checkpoint... 
Iteration: 250702539, states[0] = -94.503253, states[40]= 0.000000
Saving checkpoint... 
Iteration: 259910055, states[0] = -94.868782, states[40]= 0.000000
Saving checkpoint... 
Iteration: 269082857, states[0] = 1.481519, states[40]= 0.004690
Saving checkpoint... 
Iteration: 278444293, states[0] = -94.882903, states[40]= 0.000000
Saving checkpoint... 
Iteration: 287671952, states[0] = -92.577063, states[40]= 0.000000
Saving checkpoint... 
Iteration: 296933025, states[0] = -94.878691, states[40]= 0.000000
Saving checkpoint... 
Iteration: 306114632, states[0] = -27.097355, states[40]= 0.001116
Saving checkpoint... 
Iteration: 315514463, states[0] = 27.741058, states[40]= 0.011648
Saving checkpoint... 
Iteration: 324737362, states[0] = -94.630170, states[40]= 0.000000
Saving checkpoint... 
Iteration: 333606153, states[0] = -18.839996, states[40]= 0.001355
Saving checkpoint... 
Iteration: 342850813, states[0] = -94.828568, states[40]= 0.000000
Saving checkpoint... 
Iteration: 352216637, states[0] = -94.559532, states[40]= 0.000000
Saving checkpoint... 
Iteration: 361439628, states[0] = -94.880922, states[40]= 0.000000
Saving checkpoint... 
Iteration: 370702618, states[0] = -94.503109, states[40]= 0.000000
Saving checkpoint... 
Iteration: 379915070, states[0] = -94.870710, states[40]= 0.000000
Saving checkpoint... 
Iteration: 389254171, states[0] = -94.676764, states[40]= 0.000000
Saving checkpoint... 
Iteration: 398370816, states[0] = -94.844586, states[40]= 0.000000
Saving checkpoint... 
Iteration: 407739350, states[0] = -94.635843, states[40]= 0.000000
Saving checkpoint... 
Iteration: 416892998, states[0] = -94.859030, states[40]= 0.000000
Saving checkpoint... 
Iteration: 426124773, states[0] = -36.901969, states[40]= 0.000520
Saving checkpoint... 
Iteration: 435225962, states[0] = -94.592794, states[40]= 0.000000
Saving checkpoint... 
Iteration: 444502833, states[0] = 39.411933, states[40]= 0.454976
Saving checkpoint... 
Iteration: 453512529, states[0] = 27.800218, states[40]= 0.021357
Saving checkpoint... 
Iteration: 462747010, states[0] = -94.657567, states[40]= 0.000000
Saving checkpoint... 
Iteration: 472041636, states[0] = 20.697252, states[40]= 0.002330
Saving checkpoint... 
Iteration: 481313092, states[0] = -94.786513, states[40]= 0.000000
Saving checkpoint... 
Iteration: 490522469, states[0] = 26.656620, states[40]= 0.002081
Saving checkpoint... 
Iteration: 499867775, states[0] = -94.841937, states[40]= 0.000000
Saving checkpoint... 
Iteration: 509251351, states[0] = -94.669028, states[40]= 0.000000
Saving checkpoint... 
Iteration: 518425056, states[0] = -94.874608, states[40]= 0.000000
Saving checkpoint... 
Iteration: 527786642, states[0] = -94.745504, states[40]= 0.000000


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704204347457747_ORdGradInc_k_27-TESZT-conf_894.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704204347457747_ORdGradInc_k_27-TESZT-conf_894_0_r1268465767_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704204347457747_ORdGradInc_k_27-TESZT-conf_894_0_r1268465767_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 3000000.000000
 - dt: 0.002000
 - Constants to change: 17
     * GNa in INa: 104.175524
     * GNaL_b in INaL: 0.005732
     * Gto_b in Ito: 0.084246
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.031975
     * GKs_b in IKs: 0.001923
     * GK1_b in IK1: 0.163984
     * Gncx_b in INaCa_i: 0.000966
     * Pnak_b in INaK: 70.444278
     * GKb_b in IKb: 0.003805
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.032532
     * celltype in environment: 0.000000
     * cao in extracellular: 1.800000
     * ko in extracellular: 4.000000
     * nao in extracellular: 135.000000
Starting output configuration...
Output starts at iteration 1499500000.
Num states to save: 1.
Num rates to save: 0.
Num algebraics to save: 0.
Loading checkpoint...
Loading iteration number...
 - Iteration number: 527786642
Loading states...
 - states[0]: -87.000000 (Before loading)
 - states[40]: 0.000000 (Before loading)
 - states[0]: -94.745504 (After loading)
 - states[40]: 0.000000 (After loading)
Loading output...
Loading postprocessing...
Loading startTime...
Loading startAP...
Loading num AP...
Loading last results...
Postprocessing loaded.
Simulation loaded.
Checkpoint loaded.
Saving checkpoint... 
Iteration: 537278061, states[0] = -94.729494, states[40]= 0.000000
Saving checkpoint... 
Iteration: 546679137, states[0] = -94.182259, states[40]= 0.000000
Saving checkpoint... 
Iteration: 556119325, states[0] = -31.614018, states[40]= 0.000869
Saving checkpoint... 
Iteration: 565327906, states[0] = -94.804479, states[40]= 0.000000
Saving checkpoint... 
Iteration: 574640148, states[0] = -52.680923, states[40]= 0.000060
Saving checkpoint... 
Iteration: 584032427, states[0] = 23.909356, states[40]= 0.001818
Saving checkpoint... 
Iteration: 593306017, states[0] = -94.776273, states[40]= 0.000000
Saving checkpoint... 
Iteration: 602604190, states[0] = -16.886203, states[40]= 0.001517
Saving checkpoint... 
Iteration: 611990842, states[0] = -94.894418, states[40]= 0.000000
Saving checkpoint... 
Iteration: 621163418, states[0] = -82.757035, states[40]= 0.000000
Saving checkpoint... 
Iteration: 630387831, states[0] = -94.855113, states[40]= 0.000000
Saving checkpoint... 
Iteration: 639826294, states[0] = -94.802338, states[40]= 0.000000
Saving checkpoint... 
Iteration: 649139959, states[0] = -52.478678, states[40]= 0.000062
Saving checkpoint... 
Iteration: 658525404, states[0] = 25.966193, states[40]= 0.001749
Saving checkpoint... 
Iteration: 667685316, states[0] = -94.392543, states[40]= 0.000000
Saving checkpoint... 
Iteration: 677021054, states[0] = 26.942055, states[40]= 0.002462
Saving checkpoint... 
Iteration: 686294843, states[0] = -94.758820, states[40]= 0.000000
Saving checkpoint... 
Iteration: 695570154, states[0] = 8.654536, states[40]= 0.004449
Saving checkpoint... 
Iteration: 704914301, states[0] = -94.869099, states[40]= 0.000000
Saving checkpoint... 
Iteration: 714006311, states[0] = 29.185926, states[40]= 0.166688
Saving checkpoint... 
Iteration: 723439339, states[0] = -94.879424, states[40]= 0.000000
Saving checkpoint... 
Iteration: 732799161, states[0] = -94.765491, states[40]= 0.000000
Saving checkpoint... 
Iteration: 742141298, states[0] = -53.911667, states[40]= 0.000050
Saving checkpoint... 
Iteration: 751446160, states[0] = -94.881719, states[40]= 0.000000
Saving checkpoint... 
Iteration: 760672599, states[0] = -92.873377, states[40]= 0.000000
Saving checkpoint... 
Iteration: 769878377, states[0] = -94.848475, states[40]= 0.000000
Saving checkpoint... 
Iteration: 778961546, states[0] = -94.886453, states[40]= 0.000000
Saving checkpoint... 
Iteration: 788250370, states[0] = -94.665361, states[40]= 0.000000
Saving checkpoint... 
Iteration: 797495275, states[0] = -94.894627, states[40]= 0.000000
Saving checkpoint... 
Iteration: 806761419, states[0] = -94.692824, states[40]= 0.000000
Saving checkpoint... 
Iteration: 816090399, states[0] = -3.955863, states[40]= 0.004025
Saving checkpoint... 
Iteration: 825397708, states[0] = -94.860140, states[40]= 0.000000
Saving checkpoint... 
Iteration: 834785284, states[0] = -94.741887, states[40]= 0.000000
Saving checkpoint... 
Iteration: 844144195, states[0] = -57.044644, states[40]= 0.000030
Saving checkpoint... 
Iteration: 853456571, states[0] = -94.884685, states[40]= 0.000000
Saving checkpoint... 
Iteration: 862851931, states[0] = -94.827560, states[40]= 0.000000
Saving checkpoint... 
Iteration: 872105304, states[0] = -17.995015, states[40]= 0.001416
Saving checkpoint... 
Iteration: 881318136, states[0] = -94.791521, states[40]= 0.000000
Saving checkpoint... 
Iteration: 890547846, states[0] = 18.349621, states[40]= 0.002780
Saving checkpoint... 
Iteration: 899689383, states[0] = -94.433456, states[40]= 0.000000
Saving checkpoint... 
Iteration: 908841187, states[0] = -94.817294, states[40]= 0.000000
Saving checkpoint... 
Iteration: 917951747, states[0] = -94.882926, states[40]= 0.000000
Saving checkpoint... 
Iteration: 927303028, states[0] = -94.770609, states[40]= 0.000000
Saving checkpoint... 
Iteration: 936530967, states[0] = 24.374231, states[40]= 0.001764
Saving checkpoint... 
Iteration: 945761455, states[0] = -94.692369, states[40]= 0.000000
Saving checkpoint... 
Iteration: 955052133, states[0] = 16.659321, states[40]= 0.003120
Saving checkpoint... 
Iteration: 964367008, states[0] = -94.839566, states[40]= 0.000000
Saving checkpoint... 
Iteration: 973726330, states[0] = -94.591958, states[40]= 0.000000
Saving checkpoint... 
Iteration: 983070420, states[0] = 8.521613, states[40]= 0.004464
Saving checkpoint... 
Iteration: 992408328, states[0] = -94.865098, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1001696272, states[0] = -94.472204, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1010904338, states[0] = -94.862993, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1019914660, states[0] = -94.868056, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1029222839, states[0] = -94.579573, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1038632239, states[0] = -44.376145, states[40]= 0.000202
Saving checkpoint... 
Iteration: 1047949904, states[0] = -94.881828, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1057243350, states[0] = -94.645001, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1066683421, states[0] = -94.356555, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1075986940, states[0] = -94.891785, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1085339167, states[0] = -94.814587, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1094587060, states[0] = -1.396933, states[40]= 0.004433
Saving checkpoint... 
Iteration: 1104006106, states[0] = 29.398496, states[40]= 0.178349
Saving checkpoint... 
Iteration: 1113255686, states[0] = -94.677766, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1122546043, states[0] = 19.043690, states[40]= 0.002643
Saving checkpoint... 
Iteration: 1131939777, states[0] = -94.878013, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1141236847, states[0] = -94.625416, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1150596184, states[0] = -9.021427, states[40]= 0.002911
Saving checkpoint... 
Iteration: 1159918907, states[0] = -94.869465, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1169350567, states[0] = -94.825159, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1178499520, states[0] = -94.894006, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1187626223, states[0] = -38.324244, states[40]= 0.000441
Saving checkpoint... 
Iteration: 1196825112, states[0] = -94.798808, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1206071197, states[0] = 8.129055, states[40]= 0.004504
Saving checkpoint... 
Iteration: 1215373281, states[0] = -94.843219, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1224571318, states[0] = 8.067444, states[40]= 0.004510
Saving checkpoint... 
Iteration: 1233894853, states[0] = -94.856957, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1243023057, states[0] = 26.529321, states[40]= 0.001977
Saving checkpoint... 
Iteration: 1252275242, states[0] = -94.721140, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1261474699, states[0] = -94.888166, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1270591218, states[0] = -4.623338, states[40]= 0.003894
Saving checkpoint... 
Iteration: 1279692656, states[0] = -94.452704, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1288832961, states[0] = -94.807302, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1298207328, states[0] = -94.519218, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1307448694, states[0] = -94.880432, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1316662603, states[0] = -81.395754, states[40]= 0.000001
Saving checkpoint... 
Iteration: 1326041781, states[0] = 20.644837, states[40]= 0.002340
Saving checkpoint... 
Iteration: 1335200517, states[0] = -94.490219, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1344533024, states[0] = 23.715915, states[40]= 0.001844
Saving checkpoint... 
Iteration: 1353851031, states[0] = -94.824865, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1363042998, states[0] = 20.193515, states[40]= 0.002423
Saving checkpoint... 
Iteration: 1372298303, states[0] = -94.761683, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1381571090, states[0] = 8.183735, states[40]= 0.004498
Saving checkpoint... 
Iteration: 1390795419, states[0] = -94.757028, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1400012089, states[0] = 27.808015, states[40]= 0.024612
Saving checkpoint... 
Iteration: 1409319968, states[0] = -94.791777, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1418490612, states[0] = -94.891269, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1427610363, states[0] = -22.968688, states[40]= 0.001211
Saving checkpoint... 
Iteration: 1436721271, states[0] = -94.572377, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1445984603, states[0] = -94.889837, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1455221503, states[0] = -94.573140, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1464407048, states[0] = -94.862638, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1473642824, states[0] = -55.551908, states[40]= 0.000038
Saving checkpoint... 
Iteration: 1482913051, states[0] = -94.865514, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1492091799, states[0] = -5.107195, states[40]= 0.003795
Total time: 3000000.000000
State Variables:
 - v in component membrane (millivolt): -94.768740
 - CaMKt in component CaMK (millimolar): 0.012652
 - cass in component intracellular_ions (millimolar): 0.000087
 - nai in component intracellular_ions (millimolar): 6.757913
 - nass in component intracellular_ions (millimolar): 6.758009
 - ki in component intracellular_ions (millimolar): 145.124527
 - kss in component intracellular_ions (millimolar): 145.124506
 - cansr in component intracellular_ions (millimolar): 1.664629
 - cajsr in component intracellular_ions (millimolar): 1.623007
 - cai in component intracellular_ions (millimolar): 0.000089
 - m in component INa (dimensionless): 0.003667
 - hf in component INa (dimensionless): 0.877672
 - hs in component INa (dimensionless): 0.877664
 - j in component INa (dimensionless): 0.877614
 - hsp in component INa (dimensionless): 0.721437
 - jp in component INa (dimensionless): 0.877579
 - mL in component INaL (dimensionless): 0.000051
 - hL in component INaL (dimensionless): 0.704102
 - hLp in component INaL (dimensionless): 0.441728
 - a in component Ito (dimensionless): 0.000629
 - iF in component Ito (dimensionless): 0.999867
 - iS in component Ito (dimensionless): 0.612292
 - ap in component Ito (dimensionless): 0.000320
 - iFp in component Ito (dimensionless): 0.999867
 - iSp in component Ito (dimensionless): 0.683202
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.916469
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999836
 - jca in component ICaL (dimensionless): 0.999973
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.003067
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.365721
 - xs1 in component IKs (dimensionless): 0.266356
 - xs2 in component IKs (dimensionless): 0.000089
 - xk1 in component IK1 (dimensionless): 0.997372
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
18:02:00 (727230): called boinc_finish(0)

</stderr_txt>
]]>


CoMBA Research Group Logo
University San Jorge Logo

©2024 Universidad San Jorge