𝕏

Task 56002544

Name HuVeMOp_20240704012543219507_ORdGradInc_k_26-Pueyo_APDR-conf_541_1
Workunit 26595779
Created 3 Jul 2024, 23:25:49 UTC
Sent 4 Jul 2024, 0:46:51 UTC
Report deadline 7 Jul 2024, 10:22:51 UTC
Received 4 Jul 2024, 9:36:42 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 241141
Run time 1 hours 43 min 29 sec
CPU time 1 hours 27 min 28 sec
Validate state Valid
Credit 60.63
Device peak FLOPS 5.09 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-apple-darwin
Peak working set size 1.92 MB
Peak swap size 4.10 GB
Peak disk usage 0.28 MB

Stderr output

<core_client_version>7.24.3</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704012543219507_ORdGradInc_k_26-Pueyo_APDR-conf_541.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704012543219507_ORdGradInc_k_26-Pueyo_APDR-conf_541_1_r136940445_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240704012543219507_ORdGradInc_k_26-Pueyo_APDR-conf_541_1_r136940445_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 105.037971
     * GNaL_b in INaL: 0.005708
     * Gto_b in Ito: 0.082001
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.031624
     * GKs_b in IKs: 0.001920
     * GK1_b in IK1: 0.160784
     * Gncx_b in INaCa_i: 0.000967
     * Pnak_b in INaK: 70.209947
     * GKb_b in IKb: 0.003779
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.029170
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 12155094, states[0] = -90.511771, states[40]= 0.000000
Saving checkpoint... 
Iteration: 25395970, states[0] = -95.068127, states[40]= 0.000000
Saving checkpoint... 
Iteration: 37347960, states[0] = -95.030920, states[40]= 0.000000
Saving checkpoint... 
Iteration: 50853172, states[0] = -95.020325, states[40]= 0.000000
Saving checkpoint... 
Iteration: 63424653, states[0] = -95.036817, states[40]= 0.000000
Saving checkpoint... 
Iteration: 75108069, states[0] = -28.017592, states[40]= 0.000563
Saving checkpoint... 
Iteration: 87877002, states[0] = -95.013607, states[40]= 0.000000
Saving checkpoint... 
Iteration: 100963645, states[0] = -95.033252, states[40]= 0.000000
Saving checkpoint... 
Iteration: 114295696, states[0] = -94.962950, states[40]= 0.000000
Saving checkpoint... 
Iteration: 126561176, states[0] = 6.968772, states[40]= 0.004857
Saving checkpoint... 
Iteration: 141152841, states[0] = -77.612694, states[40]= 0.000000
Saving checkpoint... 
Iteration: 153598532, states[0] = -18.348095, states[40]= 0.001099
Saving checkpoint... 
Iteration: 166268674, states[0] = -94.934288, states[40]= 0.000000
Saving checkpoint... 
Iteration: 179770338, states[0] = -94.935795, states[40]= 0.000000
Saving checkpoint... 
Iteration: 190911259, states[0] = -95.016698, states[40]= 0.000000
Saving checkpoint... 
Iteration: 203257128, states[0] = -94.920406, states[40]= 0.000000
Saving checkpoint... 
Iteration: 216434715, states[0] = -95.022213, states[40]= 0.000000
Saving checkpoint... 
Iteration: 229918470, states[0] = -95.018299, states[40]= 0.000000
Saving checkpoint... 
Iteration: 242590692, states[0] = -11.023857, states[40]= 0.002140
Saving checkpoint... 
Iteration: 253916749, states[0] = -95.017777, states[40]= 0.000000
Saving checkpoint... 
Iteration: 265991661, states[0] = -95.031719, states[40]= 0.000000
Saving checkpoint... 
Iteration: 276187859, states[0] = -94.799935, states[40]= 0.000000
Saving checkpoint... 
Iteration: 289086393, states[0] = -7.389895, states[40]= 0.002901
Saving checkpoint... 
Iteration: 300649049, states[0] = -71.536157, states[40]= 0.000001
Saving checkpoint... 
Iteration: 313646097, states[0] = -67.489235, states[40]= 0.000001
Saving checkpoint... 
Iteration: 325790300, states[0] = -94.954423, states[40]= 0.000000
Saving checkpoint... 
Iteration: 337700083, states[0] = -94.827013, states[40]= 0.000000
Saving checkpoint... 
Iteration: 349889925, states[0] = -95.009769, states[40]= 0.000000
Saving checkpoint... 
Iteration: 361975213, states[0] = -95.029329, states[40]= 0.000000
Saving checkpoint... 
Iteration: 374688670, states[0] = -94.801896, states[40]= 0.000000
Saving checkpoint... 
Iteration: 386664338, states[0] = -92.846635, states[40]= 0.000000
Saving checkpoint... 
Iteration: 398747957, states[0] = -94.908254, states[40]= 0.000000
Saving checkpoint... 
Iteration: 410813248, states[0] = -94.972226, states[40]= 0.000000
Saving checkpoint... 
Iteration: 423330230, states[0] = -94.983056, states[40]= 0.000000
Saving checkpoint... 
Iteration: 435803888, states[0] = -94.965414, states[40]= 0.000000
Saving checkpoint... 
Iteration: 448889318, states[0] = -95.009501, states[40]= 0.000000
Saving checkpoint... 
Iteration: 459948701, states[0] = -95.024744, states[40]= 0.000000
Saving checkpoint... 
Iteration: 473031301, states[0] = 18.389872, states[40]= 0.006014
Saving checkpoint... 
Iteration: 486525257, states[0] = 20.151665, states[40]= 0.007167
Saving checkpoint... 
Iteration: 498815182, states[0] = -94.973498, states[40]= 0.000000
Saving checkpoint... 
Iteration: 510910602, states[0] = -95.015915, states[40]= 0.000000
Saving checkpoint... 
Iteration: 522059557, states[0] = 7.721934, states[40]= 0.004887
Saving checkpoint... 
Iteration: 535262810, states[0] = -94.926654, states[40]= 0.000000
Saving checkpoint... 
Iteration: 545614661, states[0] = -33.599994, states[40]= 0.000312
Saving checkpoint... 
Iteration: 557147345, states[0] = -69.149955, states[40]= 0.000001
Saving checkpoint... 
Iteration: 570208313, states[0] = -94.843319, states[40]= 0.000000
Saving checkpoint... 
Iteration: 582980403, states[0] = -95.029949, states[40]= 0.000000
Saving checkpoint... 
Iteration: 594889176, states[0] = -95.009362, states[40]= 0.000000
Saving checkpoint... 
Iteration: 608399506, states[0] = -95.012650, states[40]= 0.000000
Saving checkpoint... 
Iteration: 619567371, states[0] = 4.204831, states[40]= 0.004697
Saving checkpoint... 
Iteration: 631563518, states[0] = 5.987796, states[40]= 0.004807
Saving checkpoint... 
Iteration: 643308363, states[0] = -94.968612, states[40]= 0.000000
Saving checkpoint... 
Iteration: 655708501, states[0] = -94.843630, states[40]= 0.000000
Saving checkpoint... 
Iteration: 668084193, states[0] = -5.688295, states[40]= 0.003267
Saving checkpoint... 
Iteration: 680476126, states[0] = -95.029265, states[40]= 0.000000
Saving checkpoint... 
Iteration: 693345814, states[0] = -94.991372, states[40]= 0.000000
Saving checkpoint... 
Iteration: 706399436, states[0] = -95.012568, states[40]= 0.000000
Saving checkpoint... 
Iteration: 719491769, states[0] = -95.031406, states[40]= 0.000000
Saving checkpoint... 
Iteration: 731248229, states[0] = -94.908410, states[40]= 0.000000
Saving checkpoint... 
Iteration: 743751329, states[0] = -94.912483, states[40]= 0.000000
Saving checkpoint... 
Iteration: 756558949, states[0] = 7.980894, states[40]= 0.004897
Saving checkpoint... 
Iteration: 768644222, states[0] = -65.101082, states[40]= 0.000002
Saving checkpoint... 
Iteration: 782153963, states[0] = -79.277978, states[40]= 0.000000
Saving checkpoint... 
Iteration: 793190348, states[0] = -94.805671, states[40]= 0.000000
Saving checkpoint... 
Iteration: 805318468, states[0] = -94.975505, states[40]= 0.000000
Saving checkpoint... 
Iteration: 818269183, states[0] = -94.933588, states[40]= 0.000000
Saving checkpoint... 
Iteration: 828833078, states[0] = -94.984451, states[40]= 0.000000
Saving checkpoint... 
Iteration: 839902073, states[0] = -95.013277, states[40]= 0.000000
Saving checkpoint... 
Iteration: 851367534, states[0] = -95.001171, states[40]= 0.000000
Saving checkpoint... 
Iteration: 864347821, states[0] = -94.992269, states[40]= 0.000000
Saving checkpoint... 
Iteration: 876032403, states[0] = 18.037740, states[40]= 0.005886
Saving checkpoint... 
Iteration: 888791080, states[0] = -94.954741, states[40]= 0.000000
Saving checkpoint... 
Iteration: 902293693, states[0] = -94.956962, states[40]= 0.000000
Saving checkpoint... 
Iteration: 915182606, states[0] = -94.782389, states[40]= 0.000000
Saving checkpoint... 
Iteration: 928489340, states[0] = -95.030961, states[40]= 0.000000
Saving checkpoint... 
Iteration: 941301501, states[0] = -94.963262, states[40]= 0.000000
Saving checkpoint... 
Iteration: 953959082, states[0] = -95.026342, states[40]= 0.000000
Saving checkpoint... 
Iteration: 966668354, states[0] = -94.173699, states[40]= 0.000000
Saving checkpoint... 
Iteration: 979388093, states[0] = -95.008759, states[40]= 0.000000
Saving checkpoint... 
Iteration: 991043118, states[0] = 14.263859, states[40]= 0.005196
Saving checkpoint... 
Iteration: 1004064291, states[0] = 5.638626, states[40]= 0.004788
Saving checkpoint... 
Iteration: 1014338915, states[0] = -94.987573, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1027291503, states[0] = -94.955019, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1040314758, states[0] = -94.972872, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1052203837, states[0] = -94.834187, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1064860451, states[0] = -94.998033, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1076879476, states[0] = -95.005664, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1089377011, states[0] = -95.004742, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1101191625, states[0] = -94.808416, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1113626379, states[0] = -45.250320, states[40]= 0.000059
Saving checkpoint... 
Iteration: 1127296795, states[0] = -94.959394, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1139383758, states[0] = -95.007164, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1152012750, states[0] = 22.785841, states[40]= 0.028799
Saving checkpoint... 
Iteration: 1165528653, states[0] = 19.199567, states[40]= 0.006401
Saving checkpoint... 
Iteration: 1178117664, states[0] = -36.501503, states[40]= 0.000213
Saving checkpoint... 
Iteration: 1189632311, states[0] = -51.550028, states[40]= 0.000022
Saving checkpoint... 
Iteration: 1202815309, states[0] = -94.973146, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1215340746, states[0] = -94.988427, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1227465837, states[0] = -95.027316, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1239184838, states[0] = -94.790596, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1251798742, states[0] = -94.960890, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1264121043, states[0] = -39.823324, states[40]= 0.000133
Saving checkpoint... 
Iteration: 1277293038, states[0] = -94.956175, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1291465811, states[0] = -95.027272, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1304787110, states[0] = -94.950979, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1318118289, states[0] = -37.110532, states[40]= 0.000196
Saving checkpoint... 
Iteration: 1331443959, states[0] = -95.023269, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1342584725, states[0] = -6.088682, states[40]= 0.003182
Saving checkpoint... 
Iteration: 1354358347, states[0] = -94.996921, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1366181530, states[0] = -94.776931, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1379708404, states[0] = -94.842988, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1392607156, states[0] = -26.446812, states[40]= 0.000640
Saving checkpoint... 
Iteration: 1405098251, states[0] = -18.013694, states[40]= 0.001129
Saving checkpoint... 
Iteration: 1416622729, states[0] = -41.511622, states[40]= 0.000104
Saving checkpoint... 
Iteration: 1430057347, states[0] = 8.655160, states[40]= 0.004922
Saving checkpoint... 
Iteration: 1442852233, states[0] = -94.994047, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1455533090, states[0] = 17.814108, states[40]= 0.005814
Saving checkpoint... 
Iteration: 1468922329, states[0] = -95.018365, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1481174282, states[0] = -94.676383, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1493866333, states[0] = -95.000276, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1506984895, states[0] = -18.463420, states[40]= 0.001170
Saving checkpoint... 
Iteration: 1519181212, states[0] = -95.262675, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1531980517, states[0] = -95.130951, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1545038128, states[0] = 13.803174, states[40]= 0.006276
Saving checkpoint... 
Iteration: 1557524770, states[0] = -95.228864, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1570294248, states[0] = -31.360406, states[40]= 0.000399
Saving checkpoint... 
Iteration: 1583120883, states[0] = 20.759115, states[40]= 0.010527
Saving checkpoint... 
Iteration: 1595717566, states[0] = 21.795626, states[40]= 0.014362
Saving checkpoint... 
Iteration: 1607815822, states[0] = -56.716309, states[40]= 0.000010
Saving checkpoint... 
Iteration: 1621069526, states[0] = -95.129545, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1633594636, states[0] = -32.162834, states[40]= 0.000364
Saving checkpoint... 
Iteration: 1644541580, states[0] = -95.262709, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1657523067, states[0] = 19.955873, states[40]= 0.009171
Saving checkpoint... 
Iteration: 1670431336, states[0] = 16.665192, states[40]= 0.006986
Saving checkpoint... 
Iteration: 1683094632, states[0] = -32.203083, states[40]= 0.000363
Saving checkpoint... 
Iteration: 1695996024, states[0] = -33.732262, states[40]= 0.000303
Saving checkpoint... 
Iteration: 1708901553, states[0] = -39.870848, states[40]= 0.000134
Saving checkpoint... 
Iteration: 1722362077, states[0] = 0.169314, states[40]= 0.004844
Saving checkpoint... 
Iteration: 1735358708, states[0] = -95.094851, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1747621971, states[0] = -64.868573, states[40]= 0.000003
Saving checkpoint... 
Iteration: 1761490241, states[0] = -95.179974, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1774525361, states[0] = 19.103218, states[40]= 0.008263
Saving checkpoint... 
Iteration: 1786637597, states[0] = -90.115593, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1799636100, states[0] = -95.256506, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1812090167, states[0] = -13.230181, states[40]= 0.001781
Saving checkpoint... 
Iteration: 1824186152, states[0] = -94.829180, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1836684717, states[0] = -94.815477, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1849155005, states[0] = -83.222257, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1861621096, states[0] = -40.636642, states[40]= 0.000118
Saving checkpoint... 
Iteration: 1874153840, states[0] = -80.094006, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1886415944, states[0] = -95.022087, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1899840470, states[0] = -94.991629, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1912320735, states[0] = -94.978901, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1926305486, states[0] = -94.967410, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1939719561, states[0] = -94.864485, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1952460036, states[0] = -95.026654, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1966164615, states[0] = -93.009752, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1979057853, states[0] = 8.436273, states[40]= 0.004915
Saving checkpoint... 
Iteration: 1990710568, states[0] = -94.846988, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2004348722, states[0] = -94.992132, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2017172034, states[0] = -94.576697, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2030987159, states[0] = -95.030016, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2043219418, states[0] = -94.863007, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2055828085, states[0] = -94.980754, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2068890698, states[0] = -95.008926, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2081840501, states[0] = -94.987723, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2094930287, states[0] = -95.019822, states[40]= 0.000000
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.907399
 - CaMKt in component CaMK (millimolar): 0.006945
 - cass in component intracellular_ions (millimolar): 0.000074
 - nai in component intracellular_ions (millimolar): 6.566345
 - nass in component intracellular_ions (millimolar): 6.566406
 - ki in component intracellular_ions (millimolar): 145.411482
 - kss in component intracellular_ions (millimolar): 145.411463
 - cansr in component intracellular_ions (millimolar): 1.311613
 - cajsr in component intracellular_ions (millimolar): 1.273716
 - cai in component intracellular_ions (millimolar): 0.000075
 - m in component INa (dimensionless): 0.003616
 - hf in component INa (dimensionless): 0.880097
 - hs in component INa (dimensionless): 0.880092
 - j in component INa (dimensionless): 0.880063
 - hsp in component INa (dimensionless): 0.726011
 - jp in component INa (dimensionless): 0.880043
 - mL in component INaL (dimensionless): 0.000050
 - hL in component INaL (dimensionless): 0.710045
 - hLp in component INaL (dimensionless): 0.452105
 - a in component Ito (dimensionless): 0.000623
 - iF in component Ito (dimensionless): 0.999870
 - iS in component Ito (dimensionless): 0.621404
 - ap in component Ito (dimensionless): 0.000317
 - iFp in component Ito (dimensionless): 0.999870
 - iSp in component Ito (dimensionless): 0.696225
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.935140
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999885
 - jca in component ICaL (dimensionless): 0.999978
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001605
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.333493
 - xs1 in component IKs (dimensionless): 0.241197
 - xs2 in component IKs (dimensionless): 0.000088
 - xk1 in component IK1 (dimensionless): 0.997336
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
02:36:25 (55706): called boinc_finish(0)

</stderr_txt>
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