𝕏

Task 55967607

Name HuVeMOp_20240703204657424929_ORdGradInc_k_26-Pueyo_APDR-conf_664_0
Workunit 26578871
Created 3 Jul 2024, 18:47:33 UTC
Sent 3 Jul 2024, 20:05:35 UTC
Report deadline 7 Jul 2024, 5:41:35 UTC
Received 5 Jul 2024, 7:11:18 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 233272
Run time 2 hours 15 min 27 sec
CPU time 2 hours 11 min 31 sec
Validate state Valid
Credit 61.03
Device peak FLOPS 4.73 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-apple-darwin
Peak working set size 2.41 MB
Peak swap size 4.37 GB
Peak disk usage 0.30 MB

Stderr output

<core_client_version>8.0.2</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703204657424929_ORdGradInc_k_26-Pueyo_APDR-conf_664.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703204657424929_ORdGradInc_k_26-Pueyo_APDR-conf_664_0_r732841503_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703204657424929_ORdGradInc_k_26-Pueyo_APDR-conf_664_0_r732841503_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 101.432027
     * GNaL_b in INaL: 0.005597
     * Gto_b in Ito: 0.083917
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.031972
     * GKs_b in IKs: 0.001894
     * GK1_b in IK1: 0.160433
     * Gncx_b in INaCa_i: 0.000967
     * Pnak_b in INaK: 70.254084
     * GKb_b in IKb: 0.003809
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.028890
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 9174142, states[0] = -94.819872, states[40]= 0.000000
Saving checkpoint... 
Iteration: 22018854, states[0] = 20.886533, states[40]= 0.010614
Saving checkpoint... 
Iteration: 35670150, states[0] = -94.602073, states[40]= 0.000000
Saving checkpoint... 
Iteration: 48536162, states[0] = 16.263192, states[40]= 0.005442
Saving checkpoint... 
Iteration: 61971613, states[0] = -94.994671, states[40]= 0.000000
Saving checkpoint... 
Iteration: 75115118, states[0] = -35.141212, states[40]= 0.000256
Saving checkpoint... 
Iteration: 88232634, states[0] = -94.841169, states[40]= 0.000000
Saving checkpoint... 
Iteration: 101567527, states[0] = 3.810309, states[40]= 0.004654
Saving checkpoint... 
Iteration: 110522228, states[0] = 20.640852, states[40]= 0.008094
Saving checkpoint... 
Iteration: 123384865, states[0] = -94.959667, states[40]= 0.000000
Saving checkpoint... 
Iteration: 136952448, states[0] = -94.976410, states[40]= 0.000000
Saving checkpoint... 
Iteration: 149657537, states[0] = -85.709506, states[40]= 0.000000
Saving checkpoint... 
Iteration: 162498015, states[0] = -94.982373, states[40]= 0.000000
Saving checkpoint... 
Iteration: 175874941, states[0] = -94.953841, states[40]= 0.000000
Saving checkpoint... 
Iteration: 188726942, states[0] = -94.824408, states[40]= 0.000000
Saving checkpoint... 
Iteration: 202446705, states[0] = -94.973714, states[40]= 0.000000
Saving checkpoint... 
Iteration: 215514060, states[0] = 22.227632, states[40]= 0.021684
Saving checkpoint... 
Iteration: 229418526, states[0] = -94.967181, states[40]= 0.000000
Saving checkpoint... 
Iteration: 243138432, states[0] = -58.665917, states[40]= 0.000006
Saving checkpoint... 
Iteration: 256865298, states[0] = -94.949357, states[40]= 0.000000
Saving checkpoint... 
Iteration: 270100925, states[0] = -20.987417, states[40]= 0.000908
Saving checkpoint... 
Iteration: 283235068, states[0] = -94.837057, states[40]= 0.000000
Saving checkpoint... 
Iteration: 297299584, states[0] = -94.910371, states[40]= 0.000000
Saving checkpoint... 
Iteration: 311068783, states[0] = 3.316400, states[40]= 0.004612
Saving checkpoint... 
Iteration: 324328607, states[0] = -94.930626, states[40]= 0.000000
Saving checkpoint... 
Iteration: 337806358, states[0] = -94.915602, states[40]= 0.000000
Saving checkpoint... 
Iteration: 351535799, states[0] = 16.710904, states[40]= 0.005472
Saving checkpoint... 
Iteration: 365251986, states[0] = -94.861078, states[40]= 0.000000
Saving checkpoint... 
Iteration: 378919104, states[0] = -94.967112, states[40]= 0.000000
Saving checkpoint... 
Iteration: 392751102, states[0] = -94.859899, states[40]= 0.000000
Saving checkpoint... 
Iteration: 406710618, states[0] = -94.794406, states[40]= 0.000000
Saving checkpoint... 
Iteration: 420823772, states[0] = -94.927567, states[40]= 0.000000
Saving checkpoint... 
Iteration: 435001784, states[0] = 45.979800, states[40]= 0.081351
Saving checkpoint... 
Iteration: 448459199, states[0] = -94.975618, states[40]= 0.000000
Saving checkpoint... 
Iteration: 461860186, states[0] = -94.946948, states[40]= 0.000000
Saving checkpoint... 
Iteration: 475584774, states[0] = -6.461179, states[40]= 0.003098
Saving checkpoint... 
Iteration: 489230197, states[0] = -94.829170, states[40]= 0.000000
Saving checkpoint... 
Iteration: 502052437, states[0] = 10.479417, states[40]= 0.004945
Saving checkpoint... 
Iteration: 515520488, states[0] = 21.060999, states[40]= 0.009184
Saving checkpoint... 
Iteration: 529057955, states[0] = 8.219021, states[40]= 0.004874
Saving checkpoint... 
Iteration: 543238148, states[0] = -94.841555, states[40]= 0.000000
Saving checkpoint... 
Iteration: 552343016, states[0] = -94.938583, states[40]= 0.000000
Saving checkpoint... 
Iteration: 566241526, states[0] = -94.846529, states[40]= 0.000000
Saving checkpoint... 
Iteration: 579504475, states[0] = 29.869808, states[40]= 0.156500
Saving checkpoint... 
Iteration: 593055916, states[0] = 9.068062, states[40]= 0.004901
Saving checkpoint... 
Iteration: 607257765, states[0] = -94.868244, states[40]= 0.000000
Saving checkpoint... 
Iteration: 620560199, states[0] = 7.262662, states[40]= 0.004839
Saving checkpoint... 
Iteration: 633899415, states[0] = -94.961415, states[40]= 0.000000
Saving checkpoint... 
Iteration: 647214207, states[0] = -94.801080, states[40]= 0.000000
Saving checkpoint... 
Iteration: 656488506, states[0] = -94.979982, states[40]= 0.000000
Saving checkpoint... 
Iteration: 665490402, states[0] = -94.980227, states[40]= 0.000000
Saving checkpoint... 
Iteration: 679129339, states[0] = -48.784846, states[40]= 0.000034
Saving checkpoint... 
Iteration: 693166684, states[0] = -93.762759, states[40]= 0.000000
Saving checkpoint... 
Iteration: 706944109, states[0] = -94.972597, states[40]= 0.000000
Saving checkpoint... 
Iteration: 720968193, states[0] = -94.976954, states[40]= 0.000000
Saving checkpoint... 
Iteration: 734384310, states[0] = -94.956362, states[40]= 0.000000
Saving checkpoint... 
Iteration: 748027855, states[0] = 19.223945, states[40]= 0.006378
Saving checkpoint... 
Iteration: 761762020, states[0] = -94.873268, states[40]= 0.000000
Saving checkpoint... 
Iteration: 770915096, states[0] = -94.965807, states[40]= 0.000000
Saving checkpoint... 
Iteration: 784811556, states[0] = -94.919110, states[40]= 0.000000
Saving checkpoint... 
Iteration: 798372465, states[0] = -94.951882, states[40]= 0.000000
Saving checkpoint... 
Iteration: 812153585, states[0] = -78.935399, states[40]= 0.000000
Saving checkpoint... 
Iteration: 825768783, states[0] = -94.880927, states[40]= 0.000000
Saving checkpoint... 
Iteration: 835418014, states[0] = -94.966529, states[40]= 0.000000
Saving checkpoint... 
Iteration: 850580195, states[0] = -3.170217, states[40]= 0.003761
Saving checkpoint... 
Iteration: 865966771, states[0] = -94.976627, states[40]= 0.000000
Saving checkpoint... 
Iteration: 881916344, states[0] = -94.966063, states[40]= 0.000000
Saving checkpoint... 
Iteration: 897701360, states[0] = -94.775555, states[40]= 0.000000
Saving checkpoint... 
Iteration: 913029383, states[0] = 18.777452, states[40]= 0.006127
Saving checkpoint... 
Iteration: 927923699, states[0] = -94.967898, states[40]= 0.000000
Saving checkpoint... 
Iteration: 940299749, states[0] = -94.910061, states[40]= 0.000000
Saving checkpoint... 
Iteration: 955957615, states[0] = -94.975002, states[40]= 0.000000
Saving checkpoint... 
Iteration: 970028671, states[0] = 18.988016, states[40]= 0.006237
Saving checkpoint... 
Iteration: 984745823, states[0] = -94.852357, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1000145819, states[0] = -67.454963, states[40]= 0.000001
Saving checkpoint... 
Iteration: 1015286187, states[0] = -94.898338, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1030660338, states[0] = -89.512359, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1045751036, states[0] = -94.859376, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1060978858, states[0] = -94.978369, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1076708415, states[0] = -94.789664, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1091980849, states[0] = -94.978636, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1107208724, states[0] = -94.790251, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1122629994, states[0] = -49.479174, states[40]= 0.000030
Saving checkpoint... 
Iteration: 1137760954, states[0] = -94.871754, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1152913651, states[0] = -94.965168, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1168173504, states[0] = -94.596498, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1183511715, states[0] = 22.662418, states[40]= 0.035291
Saving checkpoint... 
Iteration: 1198820102, states[0] = -94.924686, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1214012786, states[0] = 22.451213, states[40]= 0.027983
Saving checkpoint... 
Iteration: 1229221646, states[0] = -94.814218, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1245038152, states[0] = 15.890786, states[40]= 0.005328
Saving checkpoint... 
Iteration: 1260353724, states[0] = -94.943452, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1275928718, states[0] = -94.968869, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1291455085, states[0] = -94.974323, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1307325178, states[0] = -94.927863, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1322881948, states[0] = -94.955127, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1337761130, states[0] = -94.871831, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1353531388, states[0] = 18.162732, states[40]= 0.005867
Saving checkpoint... 
Iteration: 1368263737, states[0] = -94.874871, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1383139617, states[0] = -59.996386, states[40]= 0.000005
Saving checkpoint... 
Iteration: 1398894867, states[0] = -94.959481, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1414036573, states[0] = 16.444444, states[40]= 0.005421
Saving checkpoint... 
Iteration: 1429567405, states[0] = 3.988461, states[40]= 0.004663
Saving checkpoint... 
Iteration: 1445114765, states[0] = -34.135924, states[40]= 0.000292
Saving checkpoint... 
Iteration: 1460720306, states[0] = -94.811692, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1470520566, states[0] = 21.044733, states[40]= 0.009126


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703204657424929_ORdGradInc_k_26-Pueyo_APDR-conf_664.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703204657424929_ORdGradInc_k_26-Pueyo_APDR-conf_664_0_r732841503_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703204657424929_ORdGradInc_k_26-Pueyo_APDR-conf_664_0_r732841503_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 101.432027
     * GNaL_b in INaL: 0.005597
     * Gto_b in Ito: 0.083917
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.031972
     * GKs_b in IKs: 0.001894
     * GK1_b in IK1: 0.160433
     * Gncx_b in INaCa_i: 0.000967
     * Pnak_b in INaK: 70.254084
     * GKb_b in IKb: 0.003809
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.028890
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Loading checkpoint...
Loading iteration number...
 - Iteration number: 1470520566
Loading states...
 - states[0]: -87.000000 (Before loading)
 - states[40]: 0.000000 (Before loading)
 - states[0]: 21.044733 (After loading)
 - states[40]: 0.009126 (After loading)
Loading output...
Loading postprocessing...
Loading startTime...
Loading startAP...
Loading num AP...
Loading last results...
Postprocessing loaded.
Simulation loaded.
Checkpoint loaded.
Saving checkpoint... 
Iteration: 1483495084, states[0] = -94.980285, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1495703664, states[0] = -94.779882, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1508808581, states[0] = -45.108886, states[40]= 0.000060
Saving checkpoint... 
Iteration: 1517006608, states[0] = -95.119328, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1530021935, states[0] = 20.404498, states[40]= 0.009608
Saving checkpoint... 
Iteration: 1538650224, states[0] = -95.201471, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1552412500, states[0] = -95.157131, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1567303015, states[0] = -41.507942, states[40]= 0.000107
Saving checkpoint... 
Iteration: 1582768078, states[0] = -95.236402, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1597791302, states[0] = -95.257307, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1612190417, states[0] = -95.257896, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1627090804, states[0] = -95.128942, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1642814908, states[0] = 22.262063, states[40]= 0.020210
Saving checkpoint... 
Iteration: 1653765736, states[0] = -95.068222, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1669574923, states[0] = -11.174904, states[40]= 0.002387
Saving checkpoint... 
Iteration: 1685305190, states[0] = -95.158518, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1700319724, states[0] = -95.183189, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1715987197, states[0] = -95.257439, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1730935987, states[0] = -95.206446, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1746116889, states[0] = -58.659432, states[40]= 0.000007
Saving checkpoint... 
Iteration: 1761159028, states[0] = -95.044492, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1775959305, states[0] = -95.233200, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1791092218, states[0] = -30.037928, states[40]= 0.000457
Saving checkpoint... 
Iteration: 1806149786, states[0] = -79.465184, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1821170959, states[0] = -94.634560, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1836513118, states[0] = 22.222962, states[40]= 0.025939
Saving checkpoint... 
Iteration: 1851238026, states[0] = -94.856676, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1866180910, states[0] = -94.731475, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1881155497, states[0] = -82.974312, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1896173008, states[0] = -94.591966, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1910570230, states[0] = 2.524008, states[40]= 0.004546
Saving checkpoint... 
Iteration: 1924674047, states[0] = -94.621180, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1939139370, states[0] = -59.806790, states[40]= 0.000005
Saving checkpoint... 
Iteration: 1953117579, states[0] = -36.901480, states[40]= 0.000202
Saving checkpoint... 
Iteration: 1966915991, states[0] = -94.965719, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1980992039, states[0] = -94.979858, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1995130058, states[0] = -49.562293, states[40]= 0.000030
Saving checkpoint... 
Iteration: 2009628006, states[0] = -47.388525, states[40]= 0.000042
Saving checkpoint... 
Iteration: 2023983487, states[0] = -94.978433, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2038231884, states[0] = -94.830863, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2052251051, states[0] = -94.858712, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2066199738, states[0] = -94.771373, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2080245736, states[0] = -94.851467, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2094370894, states[0] = -94.950351, states[40]= 0.000000
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.856306
 - CaMKt in component CaMK (millimolar): 0.007032
 - cass in component intracellular_ions (millimolar): 0.000074
 - nai in component intracellular_ions (millimolar): 6.592476
 - nass in component intracellular_ions (millimolar): 6.592537
 - ki in component intracellular_ions (millimolar): 145.383754
 - kss in component intracellular_ions (millimolar): 145.383734
 - cansr in component intracellular_ions (millimolar): 1.317102
 - cajsr in component intracellular_ions (millimolar): 1.279147
 - cai in component intracellular_ions (millimolar): 0.000075
 - m in component INa (dimensionless): 0.003635
 - hf in component INa (dimensionless): 0.879208
 - hs in component INa (dimensionless): 0.879203
 - j in component INa (dimensionless): 0.879173
 - hsp in component INa (dimensionless): 0.724338
 - jp in component INa (dimensionless): 0.879153
 - mL in component INaL (dimensionless): 0.000050
 - hL in component INaL (dimensionless): 0.708759
 - hLp in component INaL (dimensionless): 0.450774
 - a in component Ito (dimensionless): 0.000625
 - iF in component Ito (dimensionless): 0.999869
 - iS in component Ito (dimensionless): 0.621471
 - ap in component Ito (dimensionless): 0.000319
 - iFp in component Ito (dimensionless): 0.999869
 - iSp in component Ito (dimensionless): 0.696368
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.935965
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999888
 - jca in component ICaL (dimensionless): 0.999978
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001624
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.329651
 - xs1 in component IKs (dimensionless): 0.239959
 - xs2 in component IKs (dimensionless): 0.000088
 - xk1 in component IK1 (dimensionless): 0.997349
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
03:11:08 (523): called boinc_finish(0)

</stderr_txt>
]]>


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