𝕏

Task 55942188

Name HuVeMOp_20240703174428986478_ORdGradInc_k_26-Pueyo_APDR-conf_968_1
Workunit 26566461
Created 3 Jul 2024, 15:45:44 UTC
Sent 3 Jul 2024, 17:20:05 UTC
Report deadline 7 Jul 2024, 2:56:05 UTC
Received 5 Jul 2024, 1:09:40 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 224229
Run time 3 hours 4 min 8 sec
CPU time 2 hours 17 min 31 sec
Validate state Valid
Credit 68.08
Device peak FLOPS 5.85 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-pc-linux-gnu
Peak working set size 3.13 MB
Peak swap size 3.82 MB
Peak disk usage 0.30 MB

Stderr output

<core_client_version>7.24.1</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703174428986478_ORdGradInc_k_26-Pueyo_APDR-conf_968.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703174428986478_ORdGradInc_k_26-Pueyo_APDR-conf_968_1_r188429924_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240703174428986478_ORdGradInc_k_26-Pueyo_APDR-conf_968_1_r188429924_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 101.762499
     * GNaL_b in INaL: 0.006024
     * Gto_b in Ito: 0.082907
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.031490
     * GKs_b in IKs: 0.001882
     * GK1_b in IK1: 0.161804
     * Gncx_b in INaCa_i: 0.000964
     * Pnak_b in INaK: 70.077965
     * GKb_b in IKb: 0.003780
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.030278
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 13583142, states[0] = -6.699198, states[40]= 0.003041
Saving checkpoint... 
Iteration: 24801618, states[0] = -94.986506, states[40]= 0.000000
Saving checkpoint... 
Iteration: 37859849, states[0] = -95.001507, states[40]= 0.000000
Saving checkpoint... 
Iteration: 50059114, states[0] = 7.916582, states[40]= 0.004881
Saving checkpoint... 
Iteration: 62885668, states[0] = -94.992876, states[40]= 0.000000
Saving checkpoint... 
Iteration: 76833547, states[0] = -94.963934, states[40]= 0.000000
Saving checkpoint... 
Iteration: 91729286, states[0] = -94.854942, states[40]= 0.000000
Saving checkpoint... 
Iteration: 106783863, states[0] = -94.920937, states[40]= 0.000000
Saving checkpoint... 
Iteration: 121150298, states[0] = -70.616110, states[40]= 0.000001
Saving checkpoint... 
Iteration: 135310154, states[0] = -94.940102, states[40]= 0.000000
Saving checkpoint... 
Iteration: 149387050, states[0] = -94.978466, states[40]= 0.000000
Saving checkpoint... 
Iteration: 163571224, states[0] = 2.881836, states[40]= 0.004572
Saving checkpoint... 
Iteration: 177973483, states[0] = -94.998110, states[40]= 0.000000
Saving checkpoint... 
Iteration: 192293240, states[0] = -94.925232, states[40]= 0.000000
Saving checkpoint... 
Iteration: 206483798, states[0] = -94.999290, states[40]= 0.000000
Saving checkpoint... 
Iteration: 220764329, states[0] = -94.896296, states[40]= 0.000000
Saving checkpoint... 
Iteration: 234951573, states[0] = -94.993910, states[40]= 0.000000
Saving checkpoint... 
Iteration: 249023253, states[0] = 20.829888, states[40]= 0.007669
Saving checkpoint... 
Iteration: 262823027, states[0] = -94.946881, states[40]= 0.000000
Saving checkpoint... 
Iteration: 276687898, states[0] = -94.765804, states[40]= 0.000000
Saving checkpoint... 
Iteration: 290957701, states[0] = -94.994911, states[40]= 0.000000
Saving checkpoint... 
Iteration: 304359508, states[0] = -94.966321, states[40]= 0.000000
Saving checkpoint... 
Iteration: 319079045, states[0] = -1.370669, states[40]= 0.004059
Saving checkpoint... 
Iteration: 333555899, states[0] = 9.689566, states[40]= 0.004920
Saving checkpoint... 
Iteration: 346479816, states[0] = -94.998405, states[40]= 0.000000
Saving checkpoint... 
Iteration: 358677803, states[0] = -94.687123, states[40]= 0.000000
Saving checkpoint... 
Iteration: 370884377, states[0] = -94.976145, states[40]= 0.000000
Saving checkpoint... 
Iteration: 382495921, states[0] = -95.000531, states[40]= 0.000000
Saving checkpoint... 
Iteration: 395218944, states[0] = -94.830104, states[40]= 0.000000
Saving checkpoint... 
Iteration: 407746550, states[0] = -94.873656, states[40]= 0.000000
Saving checkpoint... 
Iteration: 420258563, states[0] = -94.889196, states[40]= 0.000000
Saving checkpoint... 
Iteration: 432664332, states[0] = -91.372075, states[40]= 0.000000
Saving checkpoint... 
Iteration: 444950988, states[0] = -94.993561, states[40]= 0.000000
Saving checkpoint... 
Iteration: 457922098, states[0] = -94.987281, states[40]= 0.000000
Saving checkpoint... 
Iteration: 471369459, states[0] = -94.970433, states[40]= 0.000000
Saving checkpoint... 
Iteration: 485059866, states[0] = 8.059578, states[40]= 0.004869
Saving checkpoint... 
Iteration: 498483384, states[0] = -94.998807, states[40]= 0.000000
Saving checkpoint... 
Iteration: 511487573, states[0] = -94.999371, states[40]= 0.000000
Saving checkpoint... 
Iteration: 524145890, states[0] = -64.577373, states[40]= 0.000002
Saving checkpoint... 
Iteration: 537506934, states[0] = 25.317590, states[40]= 0.106484
Saving checkpoint... 
Iteration: 550678189, states[0] = -94.694558, states[40]= 0.000000
Saving checkpoint... 
Iteration: 563288429, states[0] = -94.920418, states[40]= 0.000000
Saving checkpoint... 
Iteration: 576956661, states[0] = -94.994519, states[40]= 0.000000
Saving checkpoint... 
Iteration: 589360474, states[0] = -94.966550, states[40]= 0.000000
Saving checkpoint... 
Iteration: 601657427, states[0] = -81.607215, states[40]= 0.000000
Saving checkpoint... 
Iteration: 612353411, states[0] = -94.963306, states[40]= 0.000000
Saving checkpoint... 
Iteration: 624343386, states[0] = -94.958322, states[40]= 0.000000
Saving checkpoint... 
Iteration: 635866887, states[0] = -94.969268, states[40]= 0.000000
Saving checkpoint... 
Iteration: 646972778, states[0] = -94.997155, states[40]= 0.000000
Saving checkpoint... 
Iteration: 658779872, states[0] = -94.912335, states[40]= 0.000000
Saving checkpoint... 
Iteration: 670720014, states[0] = -94.831827, states[40]= 0.000000
Saving checkpoint... 
Iteration: 681983748, states[0] = -94.998738, states[40]= 0.000000
Saving checkpoint... 
Iteration: 693865919, states[0] = -94.968826, states[40]= 0.000000
Saving checkpoint... 
Iteration: 706419494, states[0] = -94.986466, states[40]= 0.000000
Saving checkpoint... 
Iteration: 718683031, states[0] = -94.745969, states[40]= 0.000000
Saving checkpoint... 
Iteration: 731204215, states[0] = -94.801913, states[40]= 0.000000
Saving checkpoint... 
Iteration: 743116552, states[0] = -33.674336, states[40]= 0.000318
Saving checkpoint... 
Iteration: 754762763, states[0] = -94.893977, states[40]= 0.000000
Saving checkpoint... 
Iteration: 767150666, states[0] = -70.838231, states[40]= 0.000001
Saving checkpoint... 
Iteration: 777865713, states[0] = -94.968684, states[40]= 0.000000
Saving checkpoint... 
Iteration: 789557020, states[0] = 9.235609, states[40]= 0.004906
Saving checkpoint... 
Iteration: 803280729, states[0] = -94.913075, states[40]= 0.000000
Saving checkpoint... 
Iteration: 816834111, states[0] = -94.953142, states[40]= 0.000000
Saving checkpoint... 
Iteration: 829064924, states[0] = 5.871006, states[40]= 0.004776
Saving checkpoint... 
Iteration: 841215291, states[0] = -94.823171, states[40]= 0.000000
Saving checkpoint... 
Iteration: 855038372, states[0] = 16.299467, states[40]= 0.005327
Saving checkpoint... 
Iteration: 868420597, states[0] = -94.986638, states[40]= 0.000000
Saving checkpoint... 
Iteration: 881175939, states[0] = -94.635935, states[40]= 0.000000
Saving checkpoint... 
Iteration: 892377244, states[0] = -94.973201, states[40]= 0.000000
Saving checkpoint... 
Iteration: 902983535, states[0] = -94.998563, states[40]= 0.000000
Saving checkpoint... 
Iteration: 914554898, states[0] = 10.091454, states[40]= 0.004931
Saving checkpoint... 
Iteration: 926493947, states[0] = -94.999927, states[40]= 0.000000
Saving checkpoint... 
Iteration: 938701695, states[0] = -94.796681, states[40]= 0.000000
Saving checkpoint... 
Iteration: 948589951, states[0] = -9.192976, states[40]= 0.002503
Saving checkpoint... 
Iteration: 957537678, states[0] = 16.540385, states[40]= 0.005365
Saving checkpoint... 
Iteration: 967400156, states[0] = -94.980919, states[40]= 0.000000
Saving checkpoint... 
Iteration: 976971410, states[0] = -94.996727, states[40]= 0.000000
Saving checkpoint... 
Iteration: 987550498, states[0] = 11.818654, states[40]= 0.004984
Saving checkpoint... 
Iteration: 997815919, states[0] = -94.941678, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1008194016, states[0] = -94.780416, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1018888779, states[0] = -94.977237, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1029089778, states[0] = -9.048687, states[40]= 0.002533
Saving checkpoint... 
Iteration: 1039759161, states[0] = -94.889513, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1051052335, states[0] = 11.104666, states[40]= 0.004961
Saving checkpoint... 
Iteration: 1062048592, states[0] = 12.549802, states[40]= 0.005012
Saving checkpoint... 
Iteration: 1073277153, states[0] = -94.909365, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1084206737, states[0] = -94.806690, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1094513451, states[0] = 22.677233, states[40]= 0.024476
Saving checkpoint... 
Iteration: 1104105318, states[0] = -23.179176, states[40]= 0.000807
Saving checkpoint... 
Iteration: 1113619418, states[0] = -36.398742, states[40]= 0.000223
Saving checkpoint... 
Iteration: 1122410283, states[0] = -94.983754, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1131267913, states[0] = -94.899577, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1141474595, states[0] = -94.997109, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1152564120, states[0] = 6.228785, states[40]= 0.004794
Saving checkpoint... 
Iteration: 1165054565, states[0] = 10.224353, states[40]= 0.004935
Saving checkpoint... 
Iteration: 1176856405, states[0] = -94.964331, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1188401756, states[0] = -94.981257, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1200044956, states[0] = 13.919460, states[40]= 0.005084
Saving checkpoint... 
Iteration: 1211340094, states[0] = -94.956195, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1222547662, states[0] = 12.903216, states[40]= 0.005028
Saving checkpoint... 
Iteration: 1233418748, states[0] = -94.985931, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1244478435, states[0] = -94.997612, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1254802180, states[0] = -94.931482, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1265531338, states[0] = 18.619644, states[40]= 0.005889
Saving checkpoint... 
Iteration: 1276363634, states[0] = -94.967475, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1287205590, states[0] = -94.804288, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1297991132, states[0] = -94.999324, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1308067903, states[0] = 4.507333, states[40]= 0.004696
Saving checkpoint... 
Iteration: 1318940940, states[0] = -94.990996, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1329715917, states[0] = -94.824001, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1340255347, states[0] = -94.884612, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1350507308, states[0] = 24.947271, states[40]= 0.098167
Saving checkpoint... 
Iteration: 1360821343, states[0] = -94.945037, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1370743760, states[0] = -94.869131, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1381425261, states[0] = -94.987448, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1393105750, states[0] = -23.580409, states[40]= 0.000789
Saving checkpoint... 
Iteration: 1403567590, states[0] = 4.653724, states[40]= 0.004705
Saving checkpoint... 
Iteration: 1414068872, states[0] = 4.049236, states[40]= 0.004664
Saving checkpoint... 
Iteration: 1424999870, states[0] = -95.000326, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1435660168, states[0] = -86.190017, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1445926877, states[0] = -94.987791, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1456620564, states[0] = -37.499318, states[40]= 0.000191
Saving checkpoint... 
Iteration: 1467869562, states[0] = -94.969821, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1478617402, states[0] = -34.478422, states[40]= 0.000287
Saving checkpoint... 
Iteration: 1489181437, states[0] = -94.734518, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1500079032, states[0] = -4.105210, states[40]= 0.003620
Saving checkpoint... 
Iteration: 1511043966, states[0] = -95.184617, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1521720798, states[0] = -58.439191, states[40]= 0.000008
Saving checkpoint... 
Iteration: 1532705550, states[0] = 28.737623, states[40]= 0.121674
Saving checkpoint... 
Iteration: 1543933167, states[0] = -78.017489, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1555478271, states[0] = -95.253439, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1566290570, states[0] = -95.266620, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1577060972, states[0] = -95.244294, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1587763877, states[0] = -95.073982, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1598216319, states[0] = -55.266033, states[40]= 0.000013
Saving checkpoint... 
Iteration: 1608765051, states[0] = -95.080237, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1619471189, states[0] = -6.161101, states[40]= 0.003564
Saving checkpoint... 
Iteration: 1630132251, states[0] = -95.216253, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1640938951, states[0] = -95.225316, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1651358411, states[0] = -95.051956, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1661880563, states[0] = -95.122893, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1672627692, states[0] = -70.714134, states[40]= 0.000001
Saving checkpoint... 
Iteration: 1682909451, states[0] = -95.182057, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1693705969, states[0] = -95.175925, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1704502803, states[0] = -95.170128, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1714529771, states[0] = 17.547152, states[40]= 0.007107
Saving checkpoint... 
Iteration: 1724309383, states[0] = -95.182057, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1735372546, states[0] = -95.103466, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1746368930, states[0] = -4.283405, states[40]= 0.004000
Saving checkpoint... 
Iteration: 1756954767, states[0] = -95.012760, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1767507369, states[0] = -95.178510, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1778178899, states[0] = -13.821311, states[40]= 0.001857
Saving checkpoint... 
Iteration: 1788543954, states[0] = -95.232101, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1798883226, states[0] = -18.456554, states[40]= 0.001203
Saving checkpoint... 
Iteration: 1809094679, states[0] = -16.348576, states[40]= 0.001336
Saving checkpoint... 
Iteration: 1820194092, states[0] = -94.816789, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1831450878, states[0] = -95.020487, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1842266102, states[0] = -94.917626, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1852921538, states[0] = -95.001035, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1863941789, states[0] = -95.001481, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1874832343, states[0] = -94.959181, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1886844457, states[0] = -94.963462, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1898363168, states[0] = -94.970701, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1909361990, states[0] = -94.969108, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1920528551, states[0] = 19.424450, states[40]= 0.006274
Saving checkpoint... 
Iteration: 1931028057, states[0] = 19.570791, states[40]= 0.006360
Saving checkpoint... 
Iteration: 1941615811, states[0] = -33.039787, states[40]= 0.000344
Saving checkpoint... 
Iteration: 1952353668, states[0] = -94.963288, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1963024794, states[0] = 20.450689, states[40]= 0.007123
Saving checkpoint... 
Iteration: 1973502839, states[0] = 38.237338, states[40]= 0.133831
Saving checkpoint... 
Iteration: 1983855585, states[0] = -94.963682, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1994231960, states[0] = -94.851203, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2004658721, states[0] = -83.839946, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2015011329, states[0] = 23.084835, states[40]= 0.038529
Saving checkpoint... 
Iteration: 2025094367, states[0] = -13.049030, states[40]= 0.001764
Saving checkpoint... 
Iteration: 2035482088, states[0] = -94.997631, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2045500020, states[0] = -92.524133, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2055019652, states[0] = 21.606725, states[40]= 0.009925
Saving checkpoint... 
Iteration: 2063763545, states[0] = -94.893996, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2073002892, states[0] = 37.883698, states[40]= 0.135716
Saving checkpoint... 
Iteration: 2083311631, states[0] = -94.937940, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2093311279, states[0] = -94.937679, states[40]= 0.000000
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.875728
 - CaMKt in component CaMK (millimolar): 0.007077
 - cass in component intracellular_ions (millimolar): 0.000074
 - nai in component intracellular_ions (millimolar): 6.590672
 - nass in component intracellular_ions (millimolar): 6.590732
 - ki in component intracellular_ions (millimolar): 145.385394
 - kss in component intracellular_ions (millimolar): 145.385375
 - cansr in component intracellular_ions (millimolar): 1.318239
 - cajsr in component intracellular_ions (millimolar): 1.280020
 - cai in component intracellular_ions (millimolar): 0.000075
 - m in component INa (dimensionless): 0.003628
 - hf in component INa (dimensionless): 0.879547
 - hs in component INa (dimensionless): 0.879542
 - j in component INa (dimensionless): 0.879512
 - hsp in component INa (dimensionless): 0.724974
 - jp in component INa (dimensionless): 0.879492
 - mL in component INaL (dimensionless): 0.000050
 - hL in component INaL (dimensionless): 0.708735
 - hLp in component INaL (dimensionless): 0.449758
 - a in component Ito (dimensionless): 0.000625
 - iF in component Ito (dimensionless): 0.999869
 - iS in component Ito (dimensionless): 0.619088
 - ap in component Ito (dimensionless): 0.000318
 - iFp in component Ito (dimensionless): 0.999869
 - iSp in component Ito (dimensionless): 0.693442
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.933713
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999880
 - jca in component ICaL (dimensionless): 0.999977
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001629
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.334329
 - xs1 in component IKs (dimensionless): 0.244510
 - xs2 in component IKs (dimensionless): 0.000088
 - xk1 in component IK1 (dimensionless): 0.997344
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
20:08:33 (916007): called boinc_finish(0)

</stderr_txt>
]]>


CoMBA Research Group Logo
University San Jorge Logo

©2024 Universidad San Jorge