𝕏

Task 55434282

Name HuVeMOp_20240630130118581586_ORdGradInc_k_25-Pueyo_APDR-conf_182_0
Workunit 26323464
Created 30 Jun 2024, 11:01:46 UTC
Sent 30 Jun 2024, 12:39:12 UTC
Report deadline 3 Jul 2024, 22:15:12 UTC
Received 30 Jun 2024, 20:47:52 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 228779
Run time 2 hours 21 min 23 sec
CPU time 2 hours 11 min 22 sec
Validate state Valid
Credit 62.80
Device peak FLOPS 4.70 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-apple-darwin
Peak working set size 2.17 MB
Peak swap size 4.13 GB
Peak disk usage 0.16 MB

Stderr output

<core_client_version>7.16.21</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630130118581586_ORdGradInc_k_25-Pueyo_APDR-conf_182.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630130118581586_ORdGradInc_k_25-Pueyo_APDR-conf_182_0_r1787370065_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630130118581586_ORdGradInc_k_25-Pueyo_APDR-conf_182_0_r1787370065_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 101.706480
     * GNaL_b in INaL: 0.007098
     * Gto_b in Ito: 0.073005
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.033871
     * GKs_b in IKs: 0.002067
     * GK1_b in IK1: 0.173719
     * Gncx_b in INaCa_i: 0.000966
     * Pnak_b in INaK: 69.250156
     * GKb_b in IKb: 0.003746
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.026587
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 13148494, states[0] = -86.379881, states[40]= 0.000000
Saving checkpoint... 
Iteration: 26675964, states[0] = -94.929224, states[40]= 0.000000
Saving checkpoint... 
Iteration: 39410743, states[0] = -95.132532, states[40]= 0.000000
Saving checkpoint... 
Iteration: 51503516, states[0] = 35.824437, states[40]= 0.140546
Saving checkpoint... 
Iteration: 64517634, states[0] = 22.862975, states[40]= 0.013129
Saving checkpoint... 
Iteration: 77393928, states[0] = -95.109232, states[40]= 0.000000
Saving checkpoint... 
Iteration: 90384459, states[0] = -95.103606, states[40]= 0.000000
Saving checkpoint... 
Iteration: 103534979, states[0] = 17.838474, states[40]= 0.005862
Saving checkpoint... 
Iteration: 116556902, states[0] = 9.129645, states[40]= 0.005046
Saving checkpoint... 
Iteration: 129294616, states[0] = -95.054922, states[40]= 0.000000
Saving checkpoint... 
Iteration: 141750873, states[0] = -95.013329, states[40]= 0.000000
Saving checkpoint... 
Iteration: 155402926, states[0] = -95.103879, states[40]= 0.000000
Saving checkpoint... 
Iteration: 168391356, states[0] = -95.100357, states[40]= 0.000000
Saving checkpoint... 
Iteration: 181334404, states[0] = -95.077951, states[40]= 0.000000
Saving checkpoint... 
Iteration: 195164088, states[0] = -94.484892, states[40]= 0.000000
Saving checkpoint... 
Iteration: 208251888, states[0] = -95.013327, states[40]= 0.000000
Saving checkpoint... 
Iteration: 221027827, states[0] = 20.289469, states[40]= 0.006857
Saving checkpoint... 
Iteration: 234177828, states[0] = -94.888240, states[40]= 0.000000
Saving checkpoint... 
Iteration: 246972236, states[0] = -95.116591, states[40]= 0.000000
Saving checkpoint... 
Iteration: 260484678, states[0] = -95.118206, states[40]= 0.000000
Saving checkpoint... 
Iteration: 273503798, states[0] = 34.639234, states[40]= 0.140942
Saving checkpoint... 
Iteration: 286431338, states[0] = -95.109575, states[40]= 0.000000
Saving checkpoint... 
Iteration: 298495008, states[0] = -95.119383, states[40]= 0.000000
Saving checkpoint... 
Iteration: 311316723, states[0] = -95.067738, states[40]= 0.000000
Saving checkpoint... 
Iteration: 323778910, states[0] = -95.040237, states[40]= 0.000000
Saving checkpoint... 
Iteration: 336859064, states[0] = -95.088548, states[40]= 0.000000
Saving checkpoint... 
Iteration: 350259235, states[0] = -95.021199, states[40]= 0.000000
Saving checkpoint... 
Iteration: 363019939, states[0] = 22.458515, states[40]= 0.010399
Saving checkpoint... 
Iteration: 375109694, states[0] = -29.858339, states[40]= 0.000468
Saving checkpoint... 
Iteration: 388254966, states[0] = -95.016521, states[40]= 0.000000
Saving checkpoint... 
Iteration: 400469341, states[0] = -95.116035, states[40]= 0.000000
Saving checkpoint... 
Iteration: 413178038, states[0] = -94.888721, states[40]= 0.000000
Saving checkpoint... 
Iteration: 425804372, states[0] = -95.059794, states[40]= 0.000000
Saving checkpoint... 
Iteration: 438801660, states[0] = -95.057926, states[40]= 0.000000
Saving checkpoint... 
Iteration: 451578745, states[0] = -1.993813, states[40]= 0.004027
Saving checkpoint... 
Iteration: 463388174, states[0] = -95.098639, states[40]= 0.000000
Saving checkpoint... 
Iteration: 476480461, states[0] = -95.117509, states[40]= 0.000000
Saving checkpoint... 
Iteration: 489280306, states[0] = -95.041348, states[40]= 0.000000
Saving checkpoint... 
Iteration: 501458279, states[0] = -95.114304, states[40]= 0.000000
Saving checkpoint... 
Iteration: 514108033, states[0] = -28.219313, states[40]= 0.000546
Saving checkpoint... 
Iteration: 526619484, states[0] = -39.762227, states[40]= 0.000134
Saving checkpoint... 
Iteration: 538958614, states[0] = -95.114336, states[40]= 0.000000
Saving checkpoint... 
Iteration: 551839273, states[0] = -95.079732, states[40]= 0.000000
Saving checkpoint... 
Iteration: 564651499, states[0] = -82.781884, states[40]= 0.000000
Saving checkpoint... 
Iteration: 577366495, states[0] = -95.091273, states[40]= 0.000000
Saving checkpoint... 
Iteration: 590001502, states[0] = 48.487505, states[40]= 0.058093
Saving checkpoint... 
Iteration: 603673369, states[0] = -94.865931, states[40]= 0.000000
Saving checkpoint... 
Iteration: 616935446, states[0] = -95.110194, states[40]= 0.000000
Saving checkpoint... 
Iteration: 629637021, states[0] = -60.055519, states[40]= 0.000005
Saving checkpoint... 
Iteration: 642080843, states[0] = -3.402143, states[40]= 0.003773
Saving checkpoint... 
Iteration: 654913655, states[0] = -95.105431, states[40]= 0.000000
Saving checkpoint... 
Iteration: 667797995, states[0] = -95.055202, states[40]= 0.000000
Saving checkpoint... 
Iteration: 680658281, states[0] = -92.380607, states[40]= 0.000000
Saving checkpoint... 
Iteration: 693751454, states[0] = -95.012364, states[40]= 0.000000
Saving checkpoint... 
Iteration: 707084495, states[0] = -6.096648, states[40]= 0.003220
Saving checkpoint... 
Iteration: 719653113, states[0] = -85.753334, states[40]= 0.000000
Saving checkpoint... 
Iteration: 732848373, states[0] = -95.083830, states[40]= 0.000000
Saving checkpoint... 
Iteration: 745327495, states[0] = -95.073614, states[40]= 0.000000
Saving checkpoint... 
Iteration: 759000859, states[0] = 45.907141, states[40]= 0.016691
Saving checkpoint... 
Iteration: 772175934, states[0] = -94.880694, states[40]= 0.000000
Saving checkpoint... 
Iteration: 784815944, states[0] = -95.066994, states[40]= 0.000000
Saving checkpoint... 
Iteration: 797949979, states[0] = -95.112765, states[40]= 0.000000
Saving checkpoint... 
Iteration: 810909364, states[0] = -95.104292, states[40]= 0.000000
Saving checkpoint... 
Iteration: 824073342, states[0] = 1.252899, states[40]= 0.004492
Saving checkpoint... 
Iteration: 837131324, states[0] = -53.073746, states[40]= 0.000017
Saving checkpoint... 
Iteration: 849672304, states[0] = -94.856402, states[40]= 0.000000
Saving checkpoint... 
Iteration: 862183843, states[0] = -94.903146, states[40]= 0.000000
Saving checkpoint... 
Iteration: 875192905, states[0] = -94.921565, states[40]= 0.000000
Saving checkpoint... 
Iteration: 887869601, states[0] = -95.092238, states[40]= 0.000000
Saving checkpoint... 
Iteration: 900412100, states[0] = -95.104917, states[40]= 0.000000
Saving checkpoint... 
Iteration: 913813157, states[0] = -95.065215, states[40]= 0.000000
Saving checkpoint... 
Iteration: 926810850, states[0] = -95.063759, states[40]= 0.000000
Saving checkpoint... 
Iteration: 939359619, states[0] = -95.088426, states[40]= 0.000000
Saving checkpoint... 
Iteration: 952025956, states[0] = 20.854701, states[40]= 0.007309
Saving checkpoint... 
Iteration: 964890380, states[0] = -95.099022, states[40]= 0.000000
Saving checkpoint... 
Iteration: 977514835, states[0] = 23.604376, states[40]= 0.019760
Saving checkpoint... 
Iteration: 990612134, states[0] = -32.278543, states[40]= 0.000360
Saving checkpoint... 
Iteration: 1003954499, states[0] = -95.113410, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1015897232, states[0] = -95.100970, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1029283638, states[0] = -95.043866, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1041978143, states[0] = -95.116888, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1054824366, states[0] = -95.071726, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1067736383, states[0] = -94.993346, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1080617539, states[0] = -37.739974, states[40]= 0.000178
Saving checkpoint... 
Iteration: 1093155047, states[0] = -88.880426, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1106466504, states[0] = -95.115225, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1119046337, states[0] = 13.570083, states[40]= 0.005257
Saving checkpoint... 
Iteration: 1131715923, states[0] = -94.962851, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1143144958, states[0] = -71.138648, states[40]= 0.000001
Saving checkpoint... 
Iteration: 1155898008, states[0] = -95.101107, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1167827062, states[0] = -95.073143, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1180392347, states[0] = -95.099481, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1193201853, states[0] = -94.938348, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1205782459, states[0] = -95.042779, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1218926610, states[0] = -95.108047, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1231231744, states[0] = -94.986868, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1243114745, states[0] = -34.894241, states[40]= 0.000261
Saving checkpoint... 
Iteration: 1255566118, states[0] = 4.994745, states[40]= 0.004831
Saving checkpoint... 
Iteration: 1267749125, states[0] = -95.009318, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1279540875, states[0] = 15.712471, states[40]= 0.005462
Saving checkpoint... 
Iteration: 1290902486, states[0] = -95.102249, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1303061211, states[0] = 7.287638, states[40]= 0.004962
Saving checkpoint... 
Iteration: 1313021601, states[0] = 22.048057, states[40]= 0.009140
Saving checkpoint... 
Iteration: 1324716343, states[0] = -94.963428, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1336948589, states[0] = -95.112222, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1349111882, states[0] = -32.027481, states[40]= 0.000371
Saving checkpoint... 
Iteration: 1360548874, states[0] = 12.547451, states[40]= 0.005193
Saving checkpoint... 
Iteration: 1371908394, states[0] = -95.103734, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1383568091, states[0] = 4.023713, states[40]= 0.004760
Saving checkpoint... 
Iteration: 1395425569, states[0] = -95.107725, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1406062091, states[0] = 6.887539, states[40]= 0.004942
Saving checkpoint... 
Iteration: 1416734777, states[0] = -94.990972, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1427833905, states[0] = -95.076586, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1438882980, states[0] = -95.096474, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1449500557, states[0] = 10.370582, states[40]= 0.000488
Saving checkpoint... 
Iteration: 1459285416, states[0] = -95.045091, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1469043751, states[0] = 14.595825, states[40]= 0.005340
Saving checkpoint... 
Iteration: 1478630129, states[0] = -51.656420, states[40]= 0.000022
Saving checkpoint... 
Iteration: 1488034589, states[0] = 18.038439, states[40]= 0.005899
Saving checkpoint... 
Iteration: 1498774550, states[0] = -95.035676, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1509526902, states[0] = -95.269494, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1521019651, states[0] = 22.317329, states[40]= 0.012205
Saving checkpoint... 
Iteration: 1532435049, states[0] = 15.863488, states[40]= 0.006757
Saving checkpoint... 
Iteration: 1543239644, states[0] = 13.526562, states[40]= 0.006339
Saving checkpoint... 
Iteration: 1554185753, states[0] = -95.234736, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1566159553, states[0] = -95.177818, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1577516677, states[0] = -59.989145, states[40]= 0.000006
Saving checkpoint... 
Iteration: 1588719322, states[0] = -95.299422, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1599806409, states[0] = -95.281292, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1612375782, states[0] = -95.223983, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1623952846, states[0] = 6.143793, states[40]= 0.005597
Saving checkpoint... 
Iteration: 1635024982, states[0] = 19.952175, states[40]= 0.008721
Saving checkpoint... 
Iteration: 1647570536, states[0] = -95.357271, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1659173942, states[0] = -95.221278, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1670432159, states[0] = 16.856421, states[40]= 0.007110
Saving checkpoint... 
Iteration: 1682869238, states[0] = -95.210593, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1694675230, states[0] = -95.361335, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1706232303, states[0] = -87.577632, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1718404495, states[0] = 33.064852, states[40]= 0.121951
Saving checkpoint... 
Iteration: 1729976762, states[0] = -95.227873, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1741918049, states[0] = -62.422417, states[40]= 0.000004
Saving checkpoint... 
Iteration: 1753447037, states[0] = -95.336487, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1766220971, states[0] = -66.791499, states[40]= 0.000002
Saving checkpoint... 
Iteration: 1777628037, states[0] = -79.311559, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1788279065, states[0] = -95.364230, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1801429140, states[0] = -95.167921, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1813758866, states[0] = -95.059334, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1826854192, states[0] = -95.114117, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1839793801, states[0] = -95.071085, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1852136770, states[0] = -61.078729, states[40]= 0.000005
Saving checkpoint... 
Iteration: 1866162220, states[0] = -94.311574, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1878136272, states[0] = -59.724237, states[40]= 0.000006
Saving checkpoint... 
Iteration: 1892050187, states[0] = 11.929040, states[40]= 0.005167
Saving checkpoint... 
Iteration: 1905543122, states[0] = 14.792810, states[40]= 0.005365
Saving checkpoint... 
Iteration: 1918697959, states[0] = -94.932580, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1932350991, states[0] = -95.085537, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1945703440, states[0] = -94.941659, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1959714867, states[0] = -94.961186, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1973444259, states[0] = -95.111432, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1986417246, states[0] = -95.105746, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2000188922, states[0] = -94.913172, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2013412964, states[0] = -95.104571, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2027835994, states[0] = -95.077326, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2043130142, states[0] = -51.675791, states[40]= 0.000022
Saving checkpoint... 
Iteration: 2059851439, states[0] = -95.084400, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2075126438, states[0] = -47.374306, states[40]= 0.000043
Saving checkpoint... 
Iteration: 2091158823, states[0] = -92.753505, states[40]= 0.000000
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.994744
 - CaMKt in component CaMK (millimolar): 0.006759
 - cass in component intracellular_ions (millimolar): 0.000073
 - nai in component intracellular_ions (millimolar): 6.612016
 - nass in component intracellular_ions (millimolar): 6.612076
 - ki in component intracellular_ions (millimolar): 145.368306
 - kss in component intracellular_ions (millimolar): 145.368286
 - cansr in component intracellular_ions (millimolar): 1.302744
 - cajsr in component intracellular_ions (millimolar): 1.265232
 - cai in component intracellular_ions (millimolar): 0.000074
 - m in component INa (dimensionless): 0.003585
 - hf in component INa (dimensionless): 0.881603
 - hs in component INa (dimensionless): 0.881599
 - j in component INa (dimensionless): 0.881573
 - hsp in component INa (dimensionless): 0.728859
 - jp in component INa (dimensionless): 0.881555
 - mL in component INaL (dimensionless): 0.000049
 - hL in component INaL (dimensionless): 0.713380
 - hLp in component INaL (dimensionless): 0.457914
 - a in component Ito (dimensionless): 0.000620
 - iF in component Ito (dimensionless): 0.999872
 - iS in component Ito (dimensionless): 0.624825
 - ap in component Ito (dimensionless): 0.000316
 - iFp in component Ito (dimensionless): 0.999872
 - iSp in component Ito (dimensionless): 0.700009
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.933542
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999883
 - jca in component ICaL (dimensionless): 0.999978
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001575
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.334928
 - xs1 in component IKs (dimensionless): 0.241419
 - xs2 in component IKs (dimensionless): 0.000087
 - xk1 in component IK1 (dimensionless): 0.997313
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
16:47:42 (98723): called boinc_finish(0)

</stderr_txt>
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