𝕏

Task 55425280

Name HuVeMOp_20240630114043648578_ORdGradInc_k_25-Pueyo_APDR-conf_474_1
Workunit 26319155
Created 30 Jun 2024, 9:41:21 UTC
Sent 30 Jun 2024, 11:12:07 UTC
Report deadline 3 Jul 2024, 20:48:07 UTC
Received 30 Jun 2024, 20:21:27 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 228779
Run time 2 hours 21 min 37 sec
CPU time 2 hours 11 min 53 sec
Validate state Valid
Credit 60.45
Device peak FLOPS 4.70 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-apple-darwin
Peak working set size 2.08 MB
Peak swap size 4.13 GB
Peak disk usage 0.30 MB

Stderr output

<core_client_version>7.16.21</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630114043648578_ORdGradInc_k_25-Pueyo_APDR-conf_474.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630114043648578_ORdGradInc_k_25-Pueyo_APDR-conf_474_1_r658321136_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630114043648578_ORdGradInc_k_25-Pueyo_APDR-conf_474_1_r658321136_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 99.955752
     * GNaL_b in INaL: 0.007442
     * Gto_b in Ito: 0.080512
     * PCa_b in ICaL: 0.000081
     * GKr_b in IKr: 0.032396
     * GKs_b in IKs: 0.001898
     * GK1_b in IK1: 0.176481
     * Gncx_b in INaCa_i: 0.000963
     * Pnak_b in INaK: 69.329217
     * GKb_b in IKb: 0.003702
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.021945
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 12596274, states[0] = -15.559839, states[40]= 0.001394
Saving checkpoint... 
Iteration: 25001871, states[0] = 45.341964, states[40]= 0.095219
Saving checkpoint... 
Iteration: 37909314, states[0] = -95.176142, states[40]= 0.000000
Saving checkpoint... 
Iteration: 51029155, states[0] = 20.122620, states[40]= 0.006095
Saving checkpoint... 
Iteration: 64943963, states[0] = -95.168246, states[40]= 0.000000
Saving checkpoint... 
Iteration: 77233121, states[0] = -95.032423, states[40]= 0.000000
Saving checkpoint... 
Iteration: 90033310, states[0] = 19.063031, states[40]= 0.005641
Saving checkpoint... 
Iteration: 102906599, states[0] = -95.151287, states[40]= 0.000000
Saving checkpoint... 
Iteration: 115735059, states[0] = -95.029426, states[40]= 0.000000
Saving checkpoint... 
Iteration: 128193864, states[0] = -94.955330, states[40]= 0.000000
Saving checkpoint... 
Iteration: 140277668, states[0] = -95.078903, states[40]= 0.000000
Saving checkpoint... 
Iteration: 158395250, states[0] = -95.144767, states[40]= 0.000000
Saving checkpoint... 
Iteration: 175358591, states[0] = -95.131069, states[40]= 0.000000
Saving checkpoint... 
Iteration: 176719577, states[0] = -95.002526, states[40]= 0.000000
Saving checkpoint... 
Iteration: 189102383, states[0] = -17.642948, states[40]= 0.001178
Saving checkpoint... 
Iteration: 201627068, states[0] = -41.021637, states[40]= 0.000125
Saving checkpoint... 
Iteration: 214069540, states[0] = 5.236651, states[40]= 0.004767
Saving checkpoint... 
Iteration: 227195578, states[0] = -94.957017, states[40]= 0.000000
Saving checkpoint... 
Iteration: 239688941, states[0] = -94.942632, states[40]= 0.000000
Saving checkpoint... 
Iteration: 252972193, states[0] = -95.160839, states[40]= 0.000000
Saving checkpoint... 
Iteration: 265596225, states[0] = -12.019707, states[40]= 0.001952
Saving checkpoint... 
Iteration: 278304302, states[0] = -95.099782, states[40]= 0.000000
Saving checkpoint... 
Iteration: 291742264, states[0] = -95.036771, states[40]= 0.000000
Saving checkpoint... 
Iteration: 304787323, states[0] = -95.086238, states[40]= 0.000000
Saving checkpoint... 
Iteration: 317836247, states[0] = -95.119757, states[40]= 0.000000
Saving checkpoint... 
Iteration: 330221600, states[0] = -95.005372, states[40]= 0.000000
Saving checkpoint... 
Iteration: 343252081, states[0] = -95.049516, states[40]= 0.000000
Saving checkpoint... 
Iteration: 355342648, states[0] = -95.123043, states[40]= 0.000000
Saving checkpoint... 
Iteration: 367583369, states[0] = -2.174524, states[40]= 0.003951
Saving checkpoint... 
Iteration: 380182801, states[0] = -94.924025, states[40]= 0.000000
Saving checkpoint... 
Iteration: 393532762, states[0] = 19.319505, states[40]= 0.005694
Saving checkpoint... 
Iteration: 406399904, states[0] = -95.145209, states[40]= 0.000000
Saving checkpoint... 
Iteration: 418859706, states[0] = -95.130904, states[40]= 0.000000
Saving checkpoint... 
Iteration: 431215378, states[0] = -94.994599, states[40]= 0.000000
Saving checkpoint... 
Iteration: 444001789, states[0] = 46.216589, states[40]= 0.086788
Saving checkpoint... 
Iteration: 456574068, states[0] = 3.051667, states[40]= 0.004610
Saving checkpoint... 
Iteration: 469744199, states[0] = -95.039256, states[40]= 0.000000
Saving checkpoint... 
Iteration: 483538530, states[0] = 17.450686, states[40]= 0.005300
Saving checkpoint... 
Iteration: 496389648, states[0] = -95.141993, states[40]= 0.000000
Saving checkpoint... 
Iteration: 509214088, states[0] = -94.992254, states[40]= 0.000000
Saving checkpoint... 
Iteration: 521899263, states[0] = -95.144942, states[40]= 0.000000
Saving checkpoint... 
Iteration: 534858220, states[0] = -95.130186, states[40]= 0.000000
Saving checkpoint... 
Iteration: 548076568, states[0] = 1.759054, states[40]= 0.004488
Saving checkpoint... 
Iteration: 561289574, states[0] = -95.087979, states[40]= 0.000000
Saving checkpoint... 
Iteration: 573595313, states[0] = -11.216066, states[40]= 0.002103
Saving checkpoint... 
Iteration: 587507525, states[0] = 25.540081, states[40]= 0.093485
Saving checkpoint... 
Iteration: 599328265, states[0] = -95.115126, states[40]= 0.000000
Saving checkpoint... 
Iteration: 612439348, states[0] = -95.154766, states[40]= 0.000000
Saving checkpoint... 
Iteration: 625670295, states[0] = -94.439134, states[40]= 0.000000
Saving checkpoint... 
Iteration: 638864304, states[0] = -95.132675, states[40]= 0.000000
Saving checkpoint... 
Iteration: 651750107, states[0] = -95.046830, states[40]= 0.000000
Saving checkpoint... 
Iteration: 665069063, states[0] = 5.462081, states[40]= 0.004779
Saving checkpoint... 
Iteration: 678101840, states[0] = -17.119896, states[40]= 0.001229
Saving checkpoint... 
Iteration: 690240881, states[0] = -95.034576, states[40]= 0.000000
Saving checkpoint... 
Iteration: 703194582, states[0] = -94.954526, states[40]= 0.000000
Saving checkpoint... 
Iteration: 716454755, states[0] = -95.157625, states[40]= 0.000000
Saving checkpoint... 
Iteration: 729440688, states[0] = -95.154958, states[40]= 0.000000
Saving checkpoint... 
Iteration: 742508948, states[0] = 24.675838, states[40]= 0.066858
Saving checkpoint... 
Iteration: 755523860, states[0] = 21.728031, states[40]= 0.007336
Saving checkpoint... 
Iteration: 768947537, states[0] = -95.156269, states[40]= 0.000000
Saving checkpoint... 
Iteration: 781511727, states[0] = 23.864681, states[40]= 0.034849
Saving checkpoint... 
Iteration: 794813727, states[0] = -95.105979, states[40]= 0.000000
Saving checkpoint... 
Iteration: 807708745, states[0] = -94.982294, states[40]= 0.000000
Saving checkpoint... 
Iteration: 821021078, states[0] = 22.322405, states[40]= 0.008675
Saving checkpoint... 
Iteration: 833867443, states[0] = -95.133807, states[40]= 0.000000
Saving checkpoint... 
Iteration: 845055352, states[0] = 11.259627, states[40]= 0.004969
Saving checkpoint... 
Iteration: 858655155, states[0] = -76.560432, states[40]= 0.000000
Saving checkpoint... 
Iteration: 870565497, states[0] = 7.065146, states[40]= 0.004857
Saving checkpoint... 
Iteration: 883434032, states[0] = -95.153471, states[40]= 0.000000
Saving checkpoint... 
Iteration: 896023637, states[0] = 21.778795, states[40]= 0.007417
Saving checkpoint... 
Iteration: 909137489, states[0] = -52.363787, states[40]= 0.000022
Saving checkpoint... 
Iteration: 921872785, states[0] = -95.135815, states[40]= 0.000000
Saving checkpoint... 
Iteration: 934558533, states[0] = 9.992118, states[40]= 0.004944
Saving checkpoint... 
Iteration: 947452537, states[0] = -95.157072, states[40]= 0.000000
Saving checkpoint... 
Iteration: 960226030, states[0] = -95.012194, states[40]= 0.000000
Saving checkpoint... 
Iteration: 972756641, states[0] = -95.054605, states[40]= 0.000000
Saving checkpoint... 
Iteration: 984602158, states[0] = -17.413414, states[40]= 0.001200
Saving checkpoint... 
Iteration: 997453954, states[0] = -95.157292, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1009518851, states[0] = 22.736856, states[40]= 0.010578
Saving checkpoint... 
Iteration: 1022248822, states[0] = -95.044942, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1035237442, states[0] = -95.029485, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1048008684, states[0] = 24.800973, states[40]= 0.071212
Saving checkpoint... 
Iteration: 1060896673, states[0] = -95.143803, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1073557175, states[0] = 10.537801, states[40]= 0.004955
Saving checkpoint... 
Iteration: 1086418129, states[0] = -95.149666, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1099397774, states[0] = -95.144108, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1112522503, states[0] = 22.028584, states[40]= 0.007889
Saving checkpoint... 
Iteration: 1125086218, states[0] = -4.058738, states[40]= 0.003605
Saving checkpoint... 
Iteration: 1138388337, states[0] = -95.141132, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1151339088, states[0] = -95.120680, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1164203176, states[0] = -94.971442, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1177578887, states[0] = 0.494325, states[40]= 0.004343
Saving checkpoint... 
Iteration: 1191125420, states[0] = -39.336271, states[40]= 0.000159
Saving checkpoint... 
Iteration: 1203139792, states[0] = -55.047014, states[40]= 0.000014
Saving checkpoint... 
Iteration: 1216605906, states[0] = -20.881116, states[40]= 0.000947
Saving checkpoint... 
Iteration: 1229905505, states[0] = -95.146251, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1242649237, states[0] = -67.069495, states[40]= 0.000002
Saving checkpoint... 
Iteration: 1256568085, states[0] = 5.910217, states[40]= 0.004804
Saving checkpoint... 
Iteration: 1269777495, states[0] = -95.076624, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1283361506, states[0] = -95.131079, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1296301982, states[0] = -95.097352, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1308694134, states[0] = -94.953179, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1322310744, states[0] = -95.103606, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1335317208, states[0] = -95.107888, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1347926618, states[0] = -95.151513, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1360831129, states[0] = -95.116238, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1373279021, states[0] = -95.078002, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1385963093, states[0] = -95.158591, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1398458266, states[0] = -95.157774, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1411170009, states[0] = -94.390670, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1423548316, states[0] = 13.950663, states[40]= 0.005033
Saving checkpoint... 
Iteration: 1436745916, states[0] = -95.040882, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1449153000, states[0] = -72.830493, states[40]= 0.000001
Saving checkpoint... 
Iteration: 1461893527, states[0] = -95.142566, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1474847346, states[0] = -95.124587, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1488042889, states[0] = 15.932761, states[40]= 0.005138
Saving checkpoint... 
Iteration: 1500790208, states[0] = -95.218513, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1513217625, states[0] = 23.083152, states[40]= 0.014083
Saving checkpoint... 
Iteration: 1526162054, states[0] = 3.036256, states[40]= 0.005203
Saving checkpoint... 
Iteration: 1539136404, states[0] = -82.777685, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1551565352, states[0] = -95.376310, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1564837204, states[0] = 15.431086, states[40]= 0.006304
Saving checkpoint... 
Iteration: 1577369392, states[0] = -95.387154, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1590334014, states[0] = 16.770735, states[40]= 0.006566
Saving checkpoint... 
Iteration: 1602563982, states[0] = -95.385514, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1614800750, states[0] = -95.303000, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1627067375, states[0] = -95.229857, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1639087974, states[0] = -95.278758, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1651511288, states[0] = 24.421714, states[40]= 0.039616
Saving checkpoint... 
Iteration: 1664699591, states[0] = -95.414578, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1677266662, states[0] = -95.390141, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1689888239, states[0] = -95.407231, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1702076148, states[0] = -95.252866, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1714839698, states[0] = 14.145592, states[40]= 0.006146
Saving checkpoint... 
Iteration: 1727564040, states[0] = -95.221466, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1740041608, states[0] = 13.241008, states[40]= 0.006045
Saving checkpoint... 
Iteration: 1751236552, states[0] = -85.719986, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1762179802, states[0] = -95.401104, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1774198965, states[0] = -95.414411, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1784844106, states[0] = -94.075585, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1796290122, states[0] = -95.283861, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1808035791, states[0] = 17.639118, states[40]= 0.005385
Saving checkpoint... 
Iteration: 1820136300, states[0] = -54.213177, states[40]= 0.000017
Saving checkpoint... 
Iteration: 1831122328, states[0] = -38.167228, states[40]= 0.000189
Saving checkpoint... 
Iteration: 1842470179, states[0] = -95.177181, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1854366249, states[0] = -95.145159, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1866002035, states[0] = 44.379942, states[40]= 0.103339
Saving checkpoint... 
Iteration: 1875751783, states[0] = -95.054830, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1886720401, states[0] = -95.007169, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1897731220, states[0] = -95.023194, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1909034492, states[0] = 18.740501, states[40]= 0.005546
Saving checkpoint... 
Iteration: 1919928833, states[0] = -95.153397, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1929961793, states[0] = -95.159311, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1939297834, states[0] = -95.094734, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1948505525, states[0] = 28.134991, states[40]= 0.140380
Saving checkpoint... 
Iteration: 1958368901, states[0] = -95.134152, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1969191426, states[0] = -94.947341, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1979512981, states[0] = 23.643433, states[40]= 0.026573
Saving checkpoint... 
Iteration: 1990619919, states[0] = -33.984165, states[40]= 0.000328
Saving checkpoint... 
Iteration: 2001557344, states[0] = 10.466689, states[40]= 0.004954
Saving checkpoint... 
Iteration: 2012666135, states[0] = -93.073470, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2024006974, states[0] = 26.041363, states[40]= 0.105780
Saving checkpoint... 
Iteration: 2035672426, states[0] = -94.682581, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2047035289, states[0] = 18.523605, states[40]= 0.005489
Saving checkpoint... 
Iteration: 2058782653, states[0] = -95.080861, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2069975828, states[0] = -95.160055, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2082007625, states[0] = 25.461307, states[40]= 0.091362
Saving checkpoint... 
Iteration: 2093403341, states[0] = -95.145003, states[40]= 0.000000
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -95.039047
 - CaMKt in component CaMK (millimolar): 0.007282
 - cass in component intracellular_ions (millimolar): 0.000075
 - nai in component intracellular_ions (millimolar): 6.597544
 - nass in component intracellular_ions (millimolar): 6.597606
 - ki in component intracellular_ions (millimolar): 145.375574
 - kss in component intracellular_ions (millimolar): 145.375554
 - cansr in component intracellular_ions (millimolar): 1.330631
 - cajsr in component intracellular_ions (millimolar): 1.291871
 - cai in component intracellular_ions (millimolar): 0.000076
 - m in component INa (dimensionless): 0.003569
 - hf in component INa (dimensionless): 0.882361
 - hs in component INa (dimensionless): 0.882356
 - j in component INa (dimensionless): 0.882328
 - hsp in component INa (dimensionless): 0.730293
 - jp in component INa (dimensionless): 0.882309
 - mL in component INaL (dimensionless): 0.000048
 - hL in component INaL (dimensionless): 0.712861
 - hLp in component INaL (dimensionless): 0.454192
 - a in component Ito (dimensionless): 0.000618
 - iF in component Ito (dimensionless): 0.999873
 - iS in component Ito (dimensionless): 0.618006
 - ap in component Ito (dimensionless): 0.000315
 - iFp in component Ito (dimensionless): 0.999873
 - iSp in component Ito (dimensionless): 0.692068
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.929042
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999867
 - jca in component ICaL (dimensionless): 0.999975
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001682
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.338675
 - xs1 in component IKs (dimensionless): 0.252497
 - xs2 in component IKs (dimensionless): 0.000086
 - xk1 in component IK1 (dimensionless): 0.997301
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
16:09:56 (98408): called boinc_finish(0)

</stderr_txt>
]]>


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