𝕏

Task 55416925

Name HuVeMOp_20240630101147606520_ORdGradInc_k_25-Pueyo_APDR-conf_219_0
Workunit 26315133
Created 30 Jun 2024, 8:12:10 UTC
Sent 30 Jun 2024, 10:04:59 UTC
Report deadline 3 Jul 2024, 19:40:59 UTC
Received 30 Jun 2024, 19:20:37 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 228779
Run time 2 hours 17 min 44 sec
CPU time 2 hours 9 min 33 sec
Validate state Valid
Credit 60.00
Device peak FLOPS 4.70 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-apple-darwin
Peak working set size 2.18 MB
Peak swap size 4.13 GB
Peak disk usage 0.29 MB

Stderr output

<core_client_version>7.16.21</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630101147606520_ORdGradInc_k_25-Pueyo_APDR-conf_219.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630101147606520_ORdGradInc_k_25-Pueyo_APDR-conf_219_0_r1528127256_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240630101147606520_ORdGradInc_k_25-Pueyo_APDR-conf_219_0_r1528127256_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 109.595845
     * GNaL_b in INaL: 0.004646
     * Gto_b in Ito: 0.082382
     * PCa_b in ICaL: 0.000081
     * GKr_b in IKr: 0.031925
     * GKs_b in IKs: 0.001797
     * GK1_b in IK1: 0.166303
     * Gncx_b in INaCa_i: 0.000958
     * Pnak_b in INaK: 68.205551
     * GKb_b in IKb: 0.003911
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.036673
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 13039479, states[0] = 13.474946, states[40]= 0.005400
Saving checkpoint... 
Iteration: 25781300, states[0] = -94.959839, states[40]= 0.000000
Saving checkpoint... 
Iteration: 39314779, states[0] = -94.968927, states[40]= 0.000000
Saving checkpoint... 
Iteration: 52742327, states[0] = -94.893147, states[40]= 0.000000
Saving checkpoint... 
Iteration: 65622257, states[0] = -47.579204, states[40]= 0.000039
Saving checkpoint... 
Iteration: 78557415, states[0] = 6.857599, states[40]= 0.004898
Saving checkpoint... 
Iteration: 91725659, states[0] = -94.856863, states[40]= 0.000000
Saving checkpoint... 
Iteration: 104178027, states[0] = -94.761778, states[40]= 0.000000
Saving checkpoint... 
Iteration: 116797420, states[0] = -94.932551, states[40]= 0.000000
Saving checkpoint... 
Iteration: 129349951, states[0] = -94.962197, states[40]= 0.000000
Saving checkpoint... 
Iteration: 142420949, states[0] = -94.984573, states[40]= 0.000000
Saving checkpoint... 
Iteration: 155727237, states[0] = -94.854356, states[40]= 0.000000
Saving checkpoint... 
Iteration: 168568886, states[0] = 1.418295, states[40]= 0.004485
Saving checkpoint... 
Iteration: 181620041, states[0] = -44.396934, states[40]= 0.000064
Saving checkpoint... 
Iteration: 194441506, states[0] = -94.987805, states[40]= 0.000000
Saving checkpoint... 
Iteration: 207151104, states[0] = -84.320838, states[40]= 0.000000
Saving checkpoint... 
Iteration: 219801138, states[0] = -94.932613, states[40]= 0.000000
Saving checkpoint... 
Iteration: 232447846, states[0] = -94.988751, states[40]= 0.000000
Saving checkpoint... 
Iteration: 244418502, states[0] = -94.982731, states[40]= 0.000000
Saving checkpoint... 
Iteration: 256698987, states[0] = -94.804339, states[40]= 0.000000
Saving checkpoint... 
Iteration: 269963226, states[0] = -94.991205, states[40]= 0.000000
Saving checkpoint... 
Iteration: 283043623, states[0] = 12.800647, states[40]= 0.005218
Saving checkpoint... 
Iteration: 296072897, states[0] = -0.869159, states[40]= 0.004189
Saving checkpoint... 
Iteration: 308587935, states[0] = -12.584778, states[40]= 0.001874
Saving checkpoint... 
Iteration: 321643202, states[0] = -71.214788, states[40]= 0.000001
Saving checkpoint... 
Iteration: 335068957, states[0] = 1.396380, states[40]= 0.004482
Saving checkpoint... 
Iteration: 347658906, states[0] = -93.116419, states[40]= 0.000000
Saving checkpoint... 
Iteration: 361052681, states[0] = 9.088596, states[40]= 0.004994
Saving checkpoint... 
Iteration: 373996319, states[0] = -94.995471, states[40]= 0.000000
Saving checkpoint... 
Iteration: 386635628, states[0] = -61.434617, states[40]= 0.000004
Saving checkpoint... 
Iteration: 399803219, states[0] = -94.933841, states[40]= 0.000000
Saving checkpoint... 
Iteration: 411588580, states[0] = -13.194530, states[40]= 0.001769
Saving checkpoint... 
Iteration: 424440041, states[0] = -94.987101, states[40]= 0.000000
Saving checkpoint... 
Iteration: 437207342, states[0] = -94.819970, states[40]= 0.000000
Saving checkpoint... 
Iteration: 450770134, states[0] = -94.906214, states[40]= 0.000000
Saving checkpoint... 
Iteration: 463687735, states[0] = -94.781302, states[40]= 0.000000
Saving checkpoint... 
Iteration: 476104601, states[0] = -28.875694, states[40]= 0.000498
Saving checkpoint... 
Iteration: 489571919, states[0] = -0.282969, states[40]= 0.004273
Saving checkpoint... 
Iteration: 501825429, states[0] = -94.947779, states[40]= 0.000000
Saving checkpoint... 
Iteration: 513914376, states[0] = -94.981515, states[40]= 0.000000
Saving checkpoint... 
Iteration: 527254272, states[0] = -94.889240, states[40]= 0.000000
Saving checkpoint... 
Iteration: 539762299, states[0] = -94.898142, states[40]= 0.000000
Saving checkpoint... 
Iteration: 552120532, states[0] = -44.880460, states[40]= 0.000059
Saving checkpoint... 
Iteration: 564328863, states[0] = -94.949644, states[40]= 0.000000
Saving checkpoint... 
Iteration: 576878196, states[0] = -94.971047, states[40]= 0.000000
Saving checkpoint... 
Iteration: 589172915, states[0] = -94.730628, states[40]= 0.000000
Saving checkpoint... 
Iteration: 600993409, states[0] = -94.994996, states[40]= 0.000000
Saving checkpoint... 
Iteration: 613007608, states[0] = 24.508477, states[40]= 0.092754
Saving checkpoint... 
Iteration: 625899229, states[0] = -94.977504, states[40]= 0.000000
Saving checkpoint... 
Iteration: 638160797, states[0] = -93.816473, states[40]= 0.000000
Saving checkpoint... 
Iteration: 651388309, states[0] = -94.974279, states[40]= 0.000000
Saving checkpoint... 
Iteration: 663158535, states[0] = -92.930603, states[40]= 0.000000
Saving checkpoint... 
Iteration: 676552906, states[0] = 8.993035, states[40]= 0.004990
Saving checkpoint... 
Iteration: 689810185, states[0] = -94.938385, states[40]= 0.000000
Saving checkpoint... 
Iteration: 701950354, states[0] = -94.988802, states[40]= 0.000000
Saving checkpoint... 
Iteration: 714370562, states[0] = -94.968269, states[40]= 0.000000
Saving checkpoint... 
Iteration: 726670873, states[0] = -94.708224, states[40]= 0.000000
Saving checkpoint... 
Iteration: 739769224, states[0] = -94.905133, states[40]= 0.000000
Saving checkpoint... 
Iteration: 752573450, states[0] = -1.207322, states[40]= 0.004138
Saving checkpoint... 
Iteration: 765255494, states[0] = -94.890494, states[40]= 0.000000
Saving checkpoint... 
Iteration: 778127823, states[0] = -52.673392, states[40]= 0.000017
Saving checkpoint... 
Iteration: 790513900, states[0] = 21.984864, states[40]= 0.023133
Saving checkpoint... 
Iteration: 803531398, states[0] = 17.345430, states[40]= 0.006066
Saving checkpoint... 
Iteration: 816589104, states[0] = -13.693790, states[40]= 0.001686
Saving checkpoint... 
Iteration: 828780547, states[0] = -94.915679, states[40]= 0.000000
Saving checkpoint... 
Iteration: 841561717, states[0] = 5.057277, states[40]= 0.004793
Saving checkpoint... 
Iteration: 854874277, states[0] = -94.969515, states[40]= 0.000000
Saving checkpoint... 
Iteration: 867611126, states[0] = -35.316786, states[40]= 0.000238
Saving checkpoint... 
Iteration: 880212025, states[0] = -94.828082, states[40]= 0.000000
Saving checkpoint... 
Iteration: 893052683, states[0] = 9.087915, states[40]= 0.004994
Saving checkpoint... 
Iteration: 905857046, states[0] = -94.962879, states[40]= 0.000000
Saving checkpoint... 
Iteration: 918717590, states[0] = -94.837589, states[40]= 0.000000
Saving checkpoint... 
Iteration: 931299888, states[0] = -94.931126, states[40]= 0.000000
Saving checkpoint... 
Iteration: 944380651, states[0] = -94.971641, states[40]= 0.000000
Saving checkpoint... 
Iteration: 957020059, states[0] = 20.641482, states[40]= 0.009926
Saving checkpoint... 
Iteration: 970062008, states[0] = 4.919400, states[40]= 0.004784
Saving checkpoint... 
Iteration: 983594662, states[0] = -19.109026, states[40]= 0.001034
Saving checkpoint... 
Iteration: 996562173, states[0] = 4.840927, states[40]= 0.004779
Saving checkpoint... 
Iteration: 1009420908, states[0] = -94.982739, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1022278840, states[0] = -94.914036, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1035604012, states[0] = -28.296168, states[40]= 0.000526
Saving checkpoint... 
Iteration: 1048488014, states[0] = -94.994077, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1060631167, states[0] = -56.350582, states[40]= 0.000009
Saving checkpoint... 
Iteration: 1073745722, states[0] = -94.878559, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1085619917, states[0] = -44.237565, states[40]= 0.000065
Saving checkpoint... 
Iteration: 1097976687, states[0] = -94.992594, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1111903821, states[0] = -94.978452, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1124072101, states[0] = -0.390454, states[40]= 0.004258
Saving checkpoint... 
Iteration: 1137820997, states[0] = -94.944824, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1150909510, states[0] = -94.979909, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1169059069, states[0] = 6.285350, states[40]= 0.004863
Saving checkpoint... 
Iteration: 1185756777, states[0] = -94.891685, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1187013243, states[0] = 22.130052, states[40]= 0.026299
Saving checkpoint... 
Iteration: 1199132702, states[0] = -58.069777, states[40]= 0.000007
Saving checkpoint... 
Iteration: 1212389785, states[0] = -94.974380, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1224762421, states[0] = -94.897840, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1237682883, states[0] = -94.770031, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1249918689, states[0] = -94.982077, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1263410870, states[0] = -94.980181, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1276366732, states[0] = -94.966491, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1289344468, states[0] = -94.957084, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1302768327, states[0] = -94.903885, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1316401791, states[0] = -94.977776, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1328278161, states[0] = -94.913231, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1339959908, states[0] = -94.989984, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1351934038, states[0] = -94.985341, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1364682918, states[0] = -94.770033, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1377489316, states[0] = -94.994027, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1390363881, states[0] = -94.965324, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1403214200, states[0] = -94.831533, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1415843732, states[0] = -94.956659, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1429755302, states[0] = -94.889855, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1442727326, states[0] = -94.852782, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1456172602, states[0] = -94.727347, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1468583319, states[0] = -8.420533, states[40]= 0.002710
Saving checkpoint... 
Iteration: 1481634773, states[0] = -60.435929, states[40]= 0.000004
Saving checkpoint... 
Iteration: 1494667334, states[0] = -94.621568, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1507548552, states[0] = 7.937171, states[40]= 0.005618
Saving checkpoint... 
Iteration: 1519936361, states[0] = -91.223380, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1532819321, states[0] = -65.070101, states[40]= 0.000002
Saving checkpoint... 
Iteration: 1545397343, states[0] = -38.730913, states[40]= 0.000152
Saving checkpoint... 
Iteration: 1558260463, states[0] = -0.338917, states[40]= 0.004782
Saving checkpoint... 
Iteration: 1571510084, states[0] = -54.508192, states[40]= 0.000014
Saving checkpoint... 
Iteration: 1583809405, states[0] = -53.838216, states[40]= 0.000015
Saving checkpoint... 
Iteration: 1596716658, states[0] = -63.217972, states[40]= 0.000003
Saving checkpoint... 
Iteration: 1608913793, states[0] = 22.394493, states[40]= 0.025239
Saving checkpoint... 
Iteration: 1621473996, states[0] = -95.250735, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1634558593, states[0] = -95.068662, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1647573153, states[0] = -95.250900, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1660334751, states[0] = -91.922988, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1673027808, states[0] = -95.204775, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1685768141, states[0] = -7.135292, states[40]= 0.003355
Saving checkpoint... 
Iteration: 1698148642, states[0] = -95.007881, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1711111441, states[0] = -95.181548, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1723760942, states[0] = -95.241090, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1736656027, states[0] = -95.236535, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1749468317, states[0] = -95.095672, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1761687912, states[0] = -29.038990, states[40]= 0.000489
Saving checkpoint... 
Iteration: 1774360927, states[0] = -95.076408, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1787044979, states[0] = -95.225324, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1799963580, states[0] = -95.243429, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1812688207, states[0] = -94.821999, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1825965305, states[0] = -95.021738, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1838697551, states[0] = -94.822590, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1850935348, states[0] = -95.000442, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1863823301, states[0] = -94.956138, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1875606720, states[0] = -31.430708, states[40]= 0.000382
Saving checkpoint... 
Iteration: 1888735049, states[0] = -94.868909, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1901366603, states[0] = -94.969477, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1914420551, states[0] = -94.984409, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1926802904, states[0] = -94.934273, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1939944029, states[0] = -94.987970, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1952679654, states[0] = -94.762080, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1965276688, states[0] = -94.911980, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1977097039, states[0] = -21.469015, states[40]= 0.000868
Saving checkpoint... 
Iteration: 1990064732, states[0] = 3.589077, states[40]= 0.004689
Saving checkpoint... 
Iteration: 2003023127, states[0] = 19.864318, states[40]= 0.008007
Saving checkpoint... 
Iteration: 2015162035, states[0] = -94.108250, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2027819829, states[0] = -94.943604, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2039625591, states[0] = -50.259893, states[40]= 0.000025
Saving checkpoint... 
Iteration: 2051967928, states[0] = -94.990748, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2064279575, states[0] = -94.914012, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2077366390, states[0] = -94.965822, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2090192498, states[0] = -94.790140, states[40]= 0.000000
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.870622
 - CaMKt in component CaMK (millimolar): 0.006872
 - cass in component intracellular_ions (millimolar): 0.000074
 - nai in component intracellular_ions (millimolar): 6.654800
 - nass in component intracellular_ions (millimolar): 6.654859
 - ki in component intracellular_ions (millimolar): 145.323128
 - kss in component intracellular_ions (millimolar): 145.323109
 - cansr in component intracellular_ions (millimolar): 1.310739
 - cajsr in component intracellular_ions (millimolar): 1.273487
 - cai in component intracellular_ions (millimolar): 0.000075
 - m in component INa (dimensionless): 0.003630
 - hf in component INa (dimensionless): 0.879458
 - hs in component INa (dimensionless): 0.879454
 - j in component INa (dimensionless): 0.879426
 - hsp in component INa (dimensionless): 0.724810
 - jp in component INa (dimensionless): 0.879408
 - mL in component INaL (dimensionless): 0.000050
 - hL in component INaL (dimensionless): 0.710466
 - hLp in component INaL (dimensionless): 0.455237
 - a in component Ito (dimensionless): 0.000625
 - iF in component Ito (dimensionless): 0.999869
 - iS in component Ito (dimensionless): 0.627239
 - ap in component Ito (dimensionless): 0.000318
 - iFp in component Ito (dimensionless): 0.999869
 - iSp in component Ito (dimensionless): 0.703445
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.940074
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999901
 - jca in component ICaL (dimensionless): 0.999981
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001597
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.326232
 - xs1 in component IKs (dimensionless): 0.230326
 - xs2 in component IKs (dimensionless): 0.000088
 - xk1 in component IK1 (dimensionless): 0.997345
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
14:42:06 (97808): called boinc_finish(0)

</stderr_txt>
]]>


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