𝕏

Task 54925405

Name HuVeMOp_20240627043541288492_ORdGradInc_k_24-Pueyo_APDR-conf_80_0
Workunit 26080939
Created 27 Jun 2024, 2:35:49 UTC
Sent 27 Jun 2024, 4:28:56 UTC
Report deadline 30 Jun 2024, 14:04:56 UTC
Received 27 Jun 2024, 9:13:22 UTC
Server state Over
Outcome Success
Client state Done
Exit status 0 (0x00000000)
Computer ID 217041
Run time 2 hours 59 min 8 sec
CPU time 2 hours 58 min 21 sec
Validate state Valid
Credit 58.52
Device peak FLOPS 3.79 GFLOPS
Application version Human ventricular cell models optimization v0.02
x86_64-apple-darwin
Peak working set size 1.88 MB
Peak swap size 4.10 GB
Peak disk usage 0.29 MB

Stderr output

<core_client_version>7.24.2</core_client_version>
<![CDATA[
<stderr_txt>


===============================================================

                --- DENIS Myocyte Simulator ---                
                      Version 0.22 - Beta                      

---------------------------------------------------------------
                                          https://denis.usj.es 
                                         Universidad San Jorge 
===============================================================

Boinc file names: 
 - INPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240627043541288492_ORdGradInc_k_24-Pueyo_APDR-conf_80.xml
 - OUTPUT_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240627043541288492_ORdGradInc_k_24-Pueyo_APDR-conf_80_0_r235523068_0
 - MARKERS_FILENAME: ../../projects/denis.usj.es_denisathome/HuVeMOp_20240627043541288492_ORdGradInc_k_24-Pueyo_APDR-conf_80_0_r235523068_1
 - CHECKPOINT_FILE: denis_checkpoint
 - CHECKPOINT_FILE_2: denis_checkpoint_2


Configuration:
 - Model name: ORd_SS_biphasic
 - Solver: FE
 - Simulation time: 4200000.000000
 - dt: 0.002000
 - Constants to change: 21
     * GNa in INa: 120.753928
     * GNaL_b in INaL: 0.008974
     * Gto_b in Ito: 0.077394
     * PCa_b in ICaL: 0.000080
     * GKr_b in IKr: 0.033084
     * GKs_b in IKs: 0.001786
     * GK1_b in IK1: 0.152473
     * Gncx_b in INaCa_i: 0.000961
     * Pnak_b in INaK: 66.121653
     * GKb_b in IKb: 0.003906
     * PNab in INab: 0.000000
     * PCab in ICab: 0.000000
     * GpCa in IpCa: 0.043926
     * celltype in environment: 0.000000
     * nCL_1 in membrane: 1000.000000
     * CL_1 in membrane: 600.000000
     * nCL_2 in membrane: 600.000000
     * CL_2 in membrane: 1000.000000
     * cao in extracellular: 1.000000
     * ko in extracellular: 4.000000
     * nao in extracellular: 144.000000
Starting output configuration...
No Output to save.
Saving checkpoint... 
Iteration: 11682471, states[0] = -94.957672, states[40]= 0.000000
Saving checkpoint... 
Iteration: 23472101, states[0] = -95.167879, states[40]= 0.000000
Saving checkpoint... 
Iteration: 35184751, states[0] = -94.911743, states[40]= 0.000000
Saving checkpoint... 
Iteration: 47053881, states[0] = 11.496443, states[40]= 0.005101
Saving checkpoint... 
Iteration: 58912980, states[0] = -95.124461, states[40]= 0.000000
Saving checkpoint... 
Iteration: 70779060, states[0] = -95.046994, states[40]= 0.000000
Saving checkpoint... 
Iteration: 82636446, states[0] = -51.475194, states[40]= 0.000024
Saving checkpoint... 
Iteration: 93928087, states[0] = -95.118191, states[40]= 0.000000
Saving checkpoint... 
Iteration: 104925802, states[0] = -95.116108, states[40]= 0.000000
Saving checkpoint... 
Iteration: 116766674, states[0] = -95.025732, states[40]= 0.000000
Saving checkpoint... 
Iteration: 128605108, states[0] = -19.924279, states[40]= 0.000997
Saving checkpoint... 
Iteration: 140421323, states[0] = -95.112358, states[40]= 0.000000
Saving checkpoint... 
Iteration: 152248494, states[0] = -95.001471, states[40]= 0.000000
Saving checkpoint... 
Iteration: 164076675, states[0] = 1.765286, states[40]= 0.004501
Saving checkpoint... 
Iteration: 175981960, states[0] = -95.122821, states[40]= 0.000000
Saving checkpoint... 
Iteration: 187793912, states[0] = -95.049683, states[40]= 0.000000
Saving checkpoint... 
Iteration: 199661586, states[0] = -85.711367, states[40]= 0.000000
Saving checkpoint... 
Iteration: 211500288, states[0] = -59.653117, states[40]= 0.000000
Saving checkpoint... 
Iteration: 223336191, states[0] = -95.078606, states[40]= 0.000000
Saving checkpoint... 
Iteration: 235167547, states[0] = -92.443162, states[40]= 0.000000
Saving checkpoint... 
Iteration: 247029694, states[0] = 20.406262, states[40]= 0.006535
Saving checkpoint... 
Iteration: 258871416, states[0] = -95.095093, states[40]= 0.000000
Saving checkpoint... 
Iteration: 270734793, states[0] = -94.980604, states[40]= 0.000000
Saving checkpoint... 
Iteration: 282303656, states[0] = -95.057127, states[40]= 0.000000
Saving checkpoint... 
Iteration: 293627317, states[0] = -40.880484, states[40]= 0.000123
Saving checkpoint... 
Iteration: 305296371, states[0] = -95.051300, states[40]= 0.000000
Saving checkpoint... 
Iteration: 317035978, states[0] = 18.425674, states[40]= 0.005771
Saving checkpoint... 
Iteration: 328846946, states[0] = -95.084092, states[40]= 0.000000
Saving checkpoint... 
Iteration: 340622660, states[0] = -36.225081, states[40]= 0.000237
Saving checkpoint... 
Iteration: 352389600, states[0] = -95.101607, states[40]= 0.000000
Saving checkpoint... 
Iteration: 364111542, states[0] = -25.742297, states[40]= 0.000711
Saving checkpoint... 
Iteration: 375857254, states[0] = -95.088975, states[40]= 0.000000
Saving checkpoint... 
Iteration: 387558171, states[0] = 10.173441, states[40]= 0.005030
Saving checkpoint... 
Iteration: 399283543, states[0] = -95.039918, states[40]= 0.000000
Saving checkpoint... 
Iteration: 411019499, states[0] = 22.974236, states[40]= 0.011079
Saving checkpoint... 
Iteration: 422760555, states[0] = -95.015517, states[40]= 0.000000
Saving checkpoint... 
Iteration: 434307046, states[0] = -95.059576, states[40]= 0.000000
Saving checkpoint... 
Iteration: 446051737, states[0] = 12.706370, states[40]= 0.005123
Saving checkpoint... 
Iteration: 457795382, states[0] = -95.050381, states[40]= 0.000000
Saving checkpoint... 
Iteration: 469544382, states[0] = 15.471706, states[40]= 0.005299
Saving checkpoint... 
Iteration: 481289333, states[0] = -95.045163, states[40]= 0.000000
Saving checkpoint... 
Iteration: 492991488, states[0] = -95.123377, states[40]= 0.000000
Saving checkpoint... 
Iteration: 504785293, states[0] = -95.041491, states[40]= 0.000000
Saving checkpoint... 
Iteration: 516547406, states[0] = 14.350994, states[40]= 0.005210
Saving checkpoint... 
Iteration: 528277412, states[0] = -95.033892, states[40]= 0.000000
Saving checkpoint... 
Iteration: 540013937, states[0] = 24.061503, states[40]= 0.024086
Saving checkpoint... 
Iteration: 551758213, states[0] = -95.012623, states[40]= 0.000000
Saving checkpoint... 
Iteration: 563481796, states[0] = -95.122043, states[40]= 0.000000
Saving checkpoint... 
Iteration: 575220962, states[0] = -94.957661, states[40]= 0.000000
Saving checkpoint... 
Iteration: 586975771, states[0] = -95.121162, states[40]= 0.000000
Saving checkpoint... 
Iteration: 598720822, states[0] = -94.957403, states[40]= 0.000000
Saving checkpoint... 
Iteration: 610465587, states[0] = -95.119565, states[40]= 0.000000
Saving checkpoint... 
Iteration: 622196924, states[0] = -94.911394, states[40]= 0.000000
Saving checkpoint... 
Iteration: 633935218, states[0] = -95.113812, states[40]= 0.000000
Saving checkpoint... 
Iteration: 645702021, states[0] = -94.921964, states[40]= 0.000000
Saving checkpoint... 
Iteration: 657436560, states[0] = -95.114089, states[40]= 0.000000
Saving checkpoint... 
Iteration: 669203933, states[0] = -94.925781, states[40]= 0.000000
Saving checkpoint... 
Iteration: 680938959, states[0] = -95.114585, states[40]= 0.000000
Saving checkpoint... 
Iteration: 692671082, states[0] = -93.955373, states[40]= 0.000000
Saving checkpoint... 
Iteration: 704413783, states[0] = -95.108618, states[40]= 0.000000
Saving checkpoint... 
Iteration: 716158693, states[0] = -80.857057, states[40]= 0.000000
Saving checkpoint... 
Iteration: 727928434, states[0] = -95.112239, states[40]= 0.000000
Saving checkpoint... 
Iteration: 739712558, states[0] = -94.942369, states[40]= 0.000000
Saving checkpoint... 
Iteration: 751335738, states[0] = -95.077923, states[40]= 0.000000
Saving checkpoint... 
Iteration: 763076765, states[0] = 1.738554, states[40]= 0.004497
Saving checkpoint... 
Iteration: 774129611, states[0] = -43.279014, states[40]= 0.000086
Saving checkpoint... 
Iteration: 785616394, states[0] = -30.255095, states[40]= 0.000487
Saving checkpoint... 
Iteration: 797338567, states[0] = -95.079456, states[40]= 0.000000
Saving checkpoint... 
Iteration: 809099662, states[0] = -14.811276, states[40]= 0.001498
Saving checkpoint... 
Iteration: 820811942, states[0] = -95.062909, states[40]= 0.000000
Saving checkpoint... 
Iteration: 832571594, states[0] = 4.327069, states[40]= 0.004734
Saving checkpoint... 
Iteration: 844331770, states[0] = -95.075612, states[40]= 0.000000
Saving checkpoint... 
Iteration: 856104007, states[0] = -18.795091, states[40]= 0.001075
Saving checkpoint... 
Iteration: 867837463, states[0] = -95.078815, states[40]= 0.000000
Saving checkpoint... 
Iteration: 879607326, states[0] = -21.853376, states[40]= 0.000889
Saving checkpoint... 
Iteration: 891349764, states[0] = -95.085169, states[40]= 0.000000
Saving checkpoint... 
Iteration: 903053446, states[0] = 12.045203, states[40]= 0.005097
Saving checkpoint... 
Iteration: 914809580, states[0] = -95.061168, states[40]= 0.000000
Saving checkpoint... 
Iteration: 926544290, states[0] = 15.505463, states[40]= 0.005302
Saving checkpoint... 
Iteration: 938317938, states[0] = -95.066956, states[40]= 0.000000
Saving checkpoint... 
Iteration: 950040187, states[0] = 16.980307, states[40]= 0.005482
Saving checkpoint... 
Iteration: 961786962, states[0] = -95.042770, states[40]= 0.000000
Saving checkpoint... 
Iteration: 973492515, states[0] = -95.123244, states[40]= 0.000000
Saving checkpoint... 
Iteration: 985268758, states[0] = -95.024575, states[40]= 0.000000
Saving checkpoint... 
Iteration: 996965775, states[0] = -95.119384, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1008758734, states[0] = -95.013005, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1020502099, states[0] = 46.775121, states[40]= 0.080416
Saving checkpoint... 
Iteration: 1032264530, states[0] = -95.019819, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1044020459, states[0] = 22.771473, states[40]= 0.010162
Saving checkpoint... 
Iteration: 1055780421, states[0] = -95.036571, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1067531230, states[0] = 19.946418, states[40]= 0.006295
Saving checkpoint... 
Iteration: 1079272661, states[0] = -95.028712, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1090972722, states[0] = -95.120428, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1102712516, states[0] = -94.942090, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1114322808, states[0] = -95.070024, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1126100264, states[0] = -15.359049, states[40]= 0.001425
Saving checkpoint... 
Iteration: 1137834721, states[0] = -95.077140, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1149577240, states[0] = 1.486991, states[40]= 0.004469
Saving checkpoint... 
Iteration: 1161323608, states[0] = -95.070504, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1173078637, states[0] = 0.730955, states[40]= 0.004379
Saving checkpoint... 
Iteration: 1184814676, states[0] = -95.064614, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1196558602, states[0] = 9.999227, states[40]= 0.005024
Saving checkpoint... 
Iteration: 1208252754, states[0] = -95.005416, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1219996502, states[0] = -95.123603, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1231766160, states[0] = -95.021557, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1243535422, states[0] = 18.610670, states[40]= 0.005819
Saving checkpoint... 
Iteration: 1255273536, states[0] = -95.029531, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1267008064, states[0] = 26.237382, states[40]= 0.083523
Saving checkpoint... 
Iteration: 1278761781, states[0] = -95.016496, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1290505763, states[0] = 29.200573, states[40]= 0.127421
Saving checkpoint... 
Iteration: 1302249021, states[0] = -95.000460, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1313991135, states[0] = -95.122883, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1325707388, states[0] = -94.932201, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1337454370, states[0] = -95.117235, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1349209470, states[0] = -94.936196, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1360971399, states[0] = -95.120077, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1372698796, states[0] = -94.914948, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1384426571, states[0] = -95.111445, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1396147881, states[0] = -64.668577, states[40]= 0.000003
Saving checkpoint... 
Iteration: 1407861822, states[0] = -95.090434, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1419591029, states[0] = -7.410784, states[40]= 0.002891
Saving checkpoint... 
Iteration: 1431284613, states[0] = -95.040351, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1443004590, states[0] = 32.277809, states[40]= 0.140613
Saving checkpoint... 
Iteration: 1454748688, states[0] = -94.999930, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1466146932, states[0] = -63.453541, states[40]= 0.000003
Saving checkpoint... 
Iteration: 1477751296, states[0] = -95.003374, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1488696815, states[0] = -94.910680, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1500403002, states[0] = -31.644452, states[40]= 0.000383
Saving checkpoint... 
Iteration: 1512064414, states[0] = 1.991428, states[40]= 0.005041
Saving checkpoint... 
Iteration: 1523715944, states[0] = 23.853618, states[40]= 0.019069
Saving checkpoint... 
Iteration: 1535362504, states[0] = -95.370379, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1547010783, states[0] = -95.311409, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1558655819, states[0] = -95.115762, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1570322414, states[0] = -60.366067, states[40]= 0.000006
Saving checkpoint... 
Iteration: 1581932301, states[0] = 17.530210, states[40]= 0.007150
Saving checkpoint... 
Iteration: 1593591230, states[0] = -95.418305, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1605228173, states[0] = -95.355467, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1616866471, states[0] = -95.230454, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1628493810, states[0] = -27.046656, states[40]= 0.000635
Saving checkpoint... 
Iteration: 1640158246, states[0] = 4.414573, states[40]= 0.005409
Saving checkpoint... 
Iteration: 1651816196, states[0] = 23.443875, states[40]= 0.018153
Saving checkpoint... 
Iteration: 1662481840, states[0] = -95.272725, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1674136244, states[0] = -83.134161, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1685776840, states[0] = -9.431959, states[40]= 0.002794
Saving checkpoint... 
Iteration: 1697428050, states[0] = 19.234440, states[40]= 0.007934
Saving checkpoint... 
Iteration: 1709101155, states[0] = 51.756575, states[40]= 0.025895
Saving checkpoint... 
Iteration: 1720757030, states[0] = -95.393354, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1732426306, states[0] = -95.355821, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1744069956, states[0] = -95.243176, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1755701452, states[0] = -35.273035, states[40]= 0.000267
Saving checkpoint... 
Iteration: 1767321745, states[0] = 21.608748, states[40]= 0.010511
Saving checkpoint... 
Iteration: 1780811280, states[0] = 25.144983, states[40]= 0.042162
Saving checkpoint... 
Iteration: 1793231817, states[0] = -75.239885, states[40]= 0.000001
Saving checkpoint... 
Iteration: 1807030721, states[0] = 19.366112, states[40]= 0.006252
Saving checkpoint... 
Iteration: 1820176564, states[0] = -94.843602, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1833857444, states[0] = -95.118970, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1847703514, states[0] = -94.945005, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1861429640, states[0] = -95.125706, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1875252236, states[0] = -95.013756, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1889088455, states[0] = -5.713824, states[40]= 0.003265
Saving checkpoint... 
Iteration: 1902971418, states[0] = -95.123919, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1916711167, states[0] = -94.941918, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1930558419, states[0] = 10.038336, states[40]= 0.005027
Saving checkpoint... 
Iteration: 1944251531, states[0] = -95.004676, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1958073376, states[0] = 3.442384, states[40]= 0.004664
Saving checkpoint... 
Iteration: 1971870704, states[0] = -95.094353, states[40]= 0.000000
Saving checkpoint... 
Iteration: 1985561586, states[0] = 8.764881, states[40]= 0.004979
Saving checkpoint... 
Iteration: 2002470689, states[0] = -95.119809, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2020397152, states[0] = -95.103214, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2038368118, states[0] = -95.092777, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2056324349, states[0] = -95.070480, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2074319192, states[0] = -95.067144, states[40]= 0.000000
Saving checkpoint... 
Iteration: 2092281419, states[0] = -95.036935, states[40]= 0.000000
Total time: 4200000.000000
State Variables:
 - v in component membrane (millivolt): -94.999381
 - CaMKt in component CaMK (millimolar): 0.006925
 - cass in component intracellular_ions (millimolar): 0.000074
 - nai in component intracellular_ions (millimolar): 6.668581
 - nass in component intracellular_ions (millimolar): 6.668643
 - ki in component intracellular_ions (millimolar): 145.310861
 - kss in component intracellular_ions (millimolar): 145.310839
 - cansr in component intracellular_ions (millimolar): 1.307824
 - cajsr in component intracellular_ions (millimolar): 1.269450
 - cai in component intracellular_ions (millimolar): 0.000075
 - m in component INa (dimensionless): 0.003583
 - hf in component INa (dimensionless): 0.881683
 - hs in component INa (dimensionless): 0.881678
 - j in component INa (dimensionless): 0.881649
 - hsp in component INa (dimensionless): 0.729007
 - jp in component INa (dimensionless): 0.881630
 - mL in component INaL (dimensionless): 0.000049
 - hL in component INaL (dimensionless): 0.711470
 - hLp in component INaL (dimensionless): 0.451874
 - a in component Ito (dimensionless): 0.000619
 - iF in component Ito (dimensionless): 0.999872
 - iS in component Ito (dimensionless): 0.616989
 - ap in component Ito (dimensionless): 0.000316
 - iFp in component Ito (dimensionless): 0.999872
 - iSp in component Ito (dimensionless): 0.690507
 - d in component ICaL (dimensionless): 0.000000
 - ff in component ICaL (dimensionless): 1.000000
 - fs in component ICaL (dimensionless): 0.928246
 - fcaf in component ICaL (dimensionless): 1.000000
 - fcas in component ICaL (dimensionless): 0.999862
 - jca in component ICaL (dimensionless): 0.999975
 - ffp in component ICaL (dimensionless): 1.000000
 - fcafp in component ICaL (dimensionless): 1.000000
 - nca in component ICaL (dimensionless): 0.001599
 - xrf in component IKr (dimensionless): 0.000003
 - xrs in component IKr (dimensionless): 0.350358
 - xs1 in component IKs (dimensionless): 0.253450
 - xs2 in component IKs (dimensionless): 0.000087
 - xk1 in component IK1 (dimensionless): 0.997311
 - Jrelnp in component ryr (millimolar_per_millisecond): 0.000000
 - Jrelp in component ryr (millimolar_per_millisecond): 0.000000
03:13:06 (85125): called boinc_finish(0)

</stderr_txt>
]]>


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