Team Publications

@article{Monasterio2018,

title = {DENIS: Solving cardiac electrophysiological simulations with volunteer computing},

author = {Monasterio, V. and Castro, J. and Carro, J.},

editor = {Alexander V. Panfilov, Universiteit Gent, BELGIUM},

url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205568

https://denis.usj.es/wp-content/uploads/2018/10/journal.pone_.0205568.pdf},

doi = {10.1371/journal.pone.0205568},

issn = {1932-6203},

year  = {2018},

date = {2018-10-16},

journal = {PLoS One},

volume = {13},

number = {10},

pages = {e0205568},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{carro2018,

title = {A response surface optimization approach to adjust ionic current conductances of cardiac electrophysiological models. Application to the study of potassium level changes},

author = {Carro, J. and Pueyo, E. and Rodríguez Matas, J.F.},

url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204411},

doi = {10.1371/journal.pone.0204411},

issn = {1932-6203},

year  = {2018},

date = {2018-10-03},

journal = {PLoS One},

volume = {13},

number = {10},

pages = {e0204411},

abstract = {Cardiac electrophysiological computational models are often developed from previously published models. The new models may incorporate additional features to adapt the model to a different species or may upgrade a specific ionic formulation based on newly available experimental data. A relevant challenge in the development of a new model is the estimation of certain ionic current conductances that cannot be reliably identified from experiments. A common strategy to estimate those conductances is by means of constrained non-linear least-squares optimization. In this work, a novel methodology is proposed for estimation of ionic current conductances of cardiac electrophysiological models by using a response surface approximation-based constrained optimization with trust region management. Polynomial response surfaces of a number of electrophysiological markers were built using statistical sampling methods. These markers included action potential duration (APD), triangulation, diastolic and systolic intracellular calcium concentration, and time constants of APD rate adaptation. The proposed methodology was applied to update the Carro et al. human ventricular action potential model after incorporation of intracellular potassium ([K+]i) dynamics. While the Carro et al. model was well suited for investigation of arrhythmogenesis, it did not allow simulation of [K+]i changes. With the methodology proposed in this study, the updated Carro et al. human ventricular model could be used to simulate [K+]i changes in response to varying extracellular potassium ([K+]o) levels. Additionally, it rendered values of evaluated electrophysiological markers within physiologically plausible ranges. The optimal values of ionic current conductances in the updated model were found in a notably shorter time than with previously proposed methodologies. As a conclusion, the response surface optimization-based approach proposed in this study allows estimating ionic current conductances of cardiac electrophysiological computational models while guaranteeing replication of key electrophysiological features and with an important reduction in computational cost with respect to previously published approaches. The updated Carro et al. model developed in this study is thus suitable for the investigation of arrhythmic risk-related conditions, including those involving large changes in potassium concentration.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ramirez2017b,

title = {Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model},

author = {Ramírez, J. and Orini, M. and Mincholé, A. and Monasterio, V. and Cygankiewicz, I. and Bayés de Luna, A. and Martínez, J.P. and Laguna, P. and Pueyo, E. },

url = {https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186152},

doi = {doi:10.1371/journal.pone.0186152},

year  = {2017},

date = {2017-10-11},

journal = {PLoS One},

volume = {12},

number = {10},

pages = {e0186152 1-15 },

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Carro2017a,

title = {Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols},

author = {Carro, J. and Rodríguez Matas, J.F. and Monasterio, V. and Pueyo, E.},

url = {http://www.sciencedirect.com/science/article/pii/S007961071630013X

http://denis.usj.es/web/wp-content/uploads/2017/06/carro2016.pdf},

doi = {10.1016/j.pbiomolbio.2016.11.006},

issn = {0079-6107},

year  = {2017},

date = {2017-10-01},

journal = {Progress in Biophysics and Molecular Biology},

volume = {129},

pages = {53-64},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{MartinYebra2017,

title = {Post-ventricular premature contraction phase correction improves the predictive value of average T-wave alternans in ambulatory ECG recordings},

author = {Martín-Yebra, A. and Monasterio, V. and Cygankiewicz, I. and Bayés de Luna, A. and Caiani, E. G. and Laguna, P. and Martínez, J. P. },

url = {https://denis.usj.es/wp-content/uploads/2018/10/AlternanciasEctopicosAlba.pdf},

doi = {10.1109/TBME.2017.2711645},

year  = {2017},

date = {2017-06-02},

journal = {IEEE Transactions Biomedical Engineering},

volume = {65},

number = {3},

pages = {635--644},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Carro2017a,

title = {A Methodology to Improve Human Ventricular Models for the Investigation of Cardiac Arrhythmias},

author = {Carro, J. and Rodríguez Matas, J.F. and Pueyo, E.},

url = {http://denis.usj.es/web/wp-content/uploads/2017/06/carro2017a.pdf},

doi = {http://dx.doi.org/10.1016/j.bpj.2016.11.2183},

issn = {0006-3495},

year  = {2017},

date = {2017-01-01},

journal = {Biophysical Journal},

volume = {112},

number = {3, Supplement 1},

pages = {403a, Published in abstract form},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ramirez2017,

title = {T-Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure},

author = {Ramírez, J. and Orini, M. and Mincholé, A. and Monasterio, V. and Cygankiewicz, I. and Bayés de Luna, A. and Martínez, J.P. and Pueyo, E. and Laguna, P.},

url = {http://jaha.ahajournals.org/content/6/5/e005310},

doi = {10.1161/JAHA.116.005310},

issn = {2047-9980},

year  = {2017},

date = {2017-01-01},

journal = {Journal of the American Heart Association},

volume = {6},

number = {5},

publisher = {American Heart Association, Inc.},

abstract = {Background Patients with chronic heart failure are at high risk of sudden cardiac death (SCD). Increased dispersion of repolarization restitution has been associated with SCD, and we hypothesize that this should be reflected in the morphology of the T-wave and its variations with heart rate. The aim of this study is to propose an electrocardiogram (ECG)-based index characterizing T-wave morphology restitution (TMR), and to assess its association with SCD risk in a population of chronic heart failure patients.Methods and Results Holter ECGs from 651 ambulatory patients with chronic heart failure from the MUSIC (MUerte S'ubita en Insuficiencia Cardiaca) study were available for the analysis. TMR was quantified by measuring the morphological variation of the T-wave per RR increment using time-warping metrics, and its predictive power was compared to that of clinical variables such as the left ventricular ejection fraction and other ECG-derived indices, such as T-wave alternans and heart rate variability. TMR was significantly higher in SCD victims than in the rest of patients (median 0.046 versus 0.039, P<0.001). When TMR was dichotomized at TMR=0.040, the SCD rate was significantly higher in the TMR>=0.040 group (P<0.001). Cox analysis revealed that TMR>=0.040 was strongly associated with SCD, with a hazard ratio of 3.27 (P<0.001), independently of clinical and ECG-derived variables. No association was found between TMR and pump failure death.Conclusions This study shows that TMR is specifically associated with SCD in a population of chronic heart failure patients, and it is a better predictor than clinical and ECG-derived variables.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{MartinYebra2015b,

title = {Evaluation of T-wave alternans activity under stress conditions after 5 days and 21 days of sedentary head-down bed-rest},

author = {Martin-Yebra, A. and Caiani, E. and Monasterio, V. and Pellegrini, A. and Laguna, P. and Martinez, J.P.},

url = {https://denis.usj.es/wp-content/uploads/2018/10/AlternansESA-Alba.pdf},

doi = {10.1088/0967-3334/36/10/2041},

year  = {2015},

date = {2015-08-19},

journal = {Physiological measurement},

volume = {36},

pages = {2041--2055},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ramirez2015,

title = {Automatic SVM classification of sudden cardiac death and pump failure death from autonomic and repolarization ECG markers},

author = {Ramírez, J. and Monasterio, V. and Mincholé, A. and Llamedo, M. and Lenis, G. and Cygankiewicz, I. and Bayés De Luna, A. and Malik, M. and Martínez, J.P. and Laguna, P. and Pueyo, E.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84937730461&partnerID=40&md5=dc33b31b3016579b83ac44fcb718ebf1},

doi = {10.1016/j.jelectrocard.2015.04.002},

year  = {2015},

date = {2015-01-01},

journal = {Journal of Electrocardiology},

volume = {48},

number = {4},

pages = {551-557},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Orini2014,

title = {Comparative evaluation of methodologies for T-wave alternans mapping in electrograms},

author = {Orini, M. and Hanson, B. and Monasterio, V. and Martínez, J.P. and Hayward, M. and Taggart, P. and Lambiase, P.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84893213627&partnerID=40&md5=01226c890c5bf30d4e5dae3a8a9bdf2b},

doi = {10.1109/TBME.2013.2289304},

year  = {2014},

date = {2014-01-01},

journal = {IEEE Transactions on Biomedical Engineering},

volume = {61},

number = {2},

pages = {308-316},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Roebuck2014,

title = {A review of signals used in sleep analysis},

author = {Roebuck, A. and Monasterio, V. and Gederi, E. and Osipov, M. and Behar, J. and Malhotra, A. and Penzel, T. and Clifford, G.D.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84891330537&partnerID=40&md5=158dcab62f5dfed3a7fb25d3e8c9a5cd},

doi = {10.1088/0967-3334/35/1/R1},

year  = {2014},

date = {2014-01-01},

journal = {Physiological Measurement},

volume = {35},

number = {1},

pages = {R1-R57},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Demidova2013,

title = {T wave alternans in experimental myocardial infarction: Time course and predictive value for the assessment of myocardial damage},

author = {Demidova, M.M. and Martín Yebra, A. and Martínez, J.P. and Monasterio, V. and Koul, S. and Van Der Pals, J. and Romero, D. and Laguna, P. and Erlinge, D. and Platonov, P.G.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84876675340&partnerID=40&md5=5cb49cdc2a3dc11ad70914f79f17c6c2},

doi = {10.1016/j.jelectrocard.2013.03.001},

year  = {2013},

date = {2013-01-01},

journal = {Journal of Electrocardiology},

volume = {46},

number = {3},

pages = {263-269},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Monasterio2013b,

title = {Prognostic value of average T-wave alternans and QT variability for cardiac events in MADIT-II patients},

author = {Monasterio, V. and Martínez, J.P. and Laguna, P. and McNitt, S. and Polonsky, S. and Moss, A.J. and Haigney, M. and Zareba, W. and Couderc, J.P.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84886954199&partnerID=40&md5=335898cd788445dd2f75b2040c9b0f96},

doi = {10.1016/j.jelectrocard.2013.08.004},

year  = {2013},

date = {2013-01-01},

journal = {Journal of Electrocardiology},

volume = {46},

number = {6},

pages = {480-486},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Monasterio2012a,

title = {Robust classification of neonatal apnoea-related desaturations},

author = {Monasterio, V. and Burgess, F. and Clifford, G.D.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84866318050&partnerID=40&md5=6e245123027bf3c04b16ac1354a42fc3},

doi = {10.1088/0967-3334/33/9/1503},

year  = {2012},

date = {2012-01-01},

journal = {Physiological Measurement},

volume = {33},

number = {9},

pages = {1503-1516},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Monasterio2012b,

title = {Average T-wave alternans activity in ambulatory ECG records predicts sudden cardiac death in patients with chronic heart failure},

author = {Monasterio, V. and Laguna, P. and Cygankiewicz, I. and Vázquez, R. and Bayés-Genís, A. and Bayés De Luna, A. and Martínez, J.P.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84857644866&partnerID=40&md5=6a1ab7e16daba9776581766782abe1ff},

doi = {10.1016/j.hrthm.2011.10.027},

year  = {2012},

date = {2012-01-01},

journal = {Heart Rhythm},

volume = {9},

number = {3},

pages = {383-389},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rodriguez2012,

title = {Impact of Multiple Ionic Changes in Arrhythmic Risk Biomarkers in Human Ventricular Electrophysiology},

author = {Rodríguez Matas, J.F. and Carro, J. and Pueyo, E. and Burrage, K. and Rodríguez, B.},

url = {http://dx.doi.org/10.1016/j.bpj.2011.11.2965},

doi = {10.1016/j.bpj.2011.11.2965},

year  = {2012},

date = {2012-01-01},

journal = {Biophysical Journal},

volume = {102},

number = {3},

pages = {543-543, Published in abstract form},

publisher = {Biophysical Journal},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Nemati2011,

title = {A nonparametric surrogate-based test of significance for T-wave alternans detection},

author = {Nemati, S. and Abdala, O. and Monasterio, V. and Yim-Yeh, S. and Malhotra, A. and Clifford, G.D.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-79955532916&partnerID=40&md5=c4aece2944a93cc05871f85b49ce506a},

doi = {10.1109/TBME.2010.2047859},

year  = {2011},

date = {2011-01-01},

journal = {IEEE Transactions on Biomedical Engineering},

volume = {58},

number = {5},

pages = {1356-1364},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Carro2011,

title = {A human ventricular cell model for investigation of cardiac arrhythmias under hyperkalaemic conditions},

author = {Carro, J. and Rodríguez Matas, J.F. and Laguna, P. and Pueyo, E.},

url = {http://dx.doi.org/10.1098/rsta.2011.0127},

doi = {10.1098/rsta.2011.0127},

year  = {2011},

date = {2011-01-01},

journal = {Philosophical Transactions of the Royal Society of London A: Mathematical, Physical and Engineering Sciences},

volume = {369},

number = {1954},

pages = {4205--4232},

publisher = {The Royal Society},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Monasterio2010b,

title = {A multilead scheme based on periodic component analysis for T-Wave alternans analysis in the ECG},

author = {Monasterio, V. and Clifford, G.D. and Laguna, P. and Martínez, J.P.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-77955175298&partnerID=40&md5=326e91fd2f21e0c6f4d8a61ef1ea317b},

doi = {10.1007/s10439-010-0029-z},

year  = {2010},

date = {2010-01-01},

journal = {Annals of Biomedical Engineering},

volume = {38},

number = {8},

pages = {2532-2541},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Monasterio2009b,

title = {Multilead analysis of T-wave alternans in the ecg using principal component analysis},

author = {Monasterio, V. and Laguna, P. and Martínez, J.P.},

url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-67650868981&partnerID=40&md5=a5771107d61106828be0b98727161405},

doi = {10.1109/TBME.2009.2015935},

year  = {2009},

date = {2009-01-01},

journal = {IEEE Transactions on Biomedical Engineering},

volume = {56},

number = {7},

pages = {1880-1890},

keywords = {},

pubstate = {published},

tppubtype = {article}

}