Abstract: The main objective of this project is the creation of a public database with the result of physiological markers under different conditions in published electrophysiological models. The models are simulated under variations of their main parameters to study how each parameter affects to the value of the markers and how they affect together.
Researchers: Jesús Carro, Joel Castro, Violeta Monasterio.
DENIS version: DENIS Kalium (version 1)
App in DENIS: Carro-Rodriguez-Laguna-Pueyo Epicardial Model (Carro et al. 2011) for human ventricular cells
Electrophysiological models published in the literature usually try to represent a “mean” model. The fact is that there is variability between cells of the same animal and between different animals. Recently, many studies try to consider this and they simulate populations of models. They made small variations to some parameters of the model to simulate the natural variability.
Each simulation of a model is computationally expensive and normally the simulations of one researcher can’t be used by other researchers.
When DENIS is not running specific research projects we use its computational capacity to generate knowledge of the published electrophysiological models. It will permit us:
- Interpolate the results of other simulations to have a fast and good aproximation to the result of a marker without run the simulation.
- Reuse the results of populations of models to other studies.
- Reduce the time spent by researchers by using previously simulated results.
Now this subproject is starting. We will add more models and more physiological markers to the database progressively. We also plan to create a REST service to permit other programs to access the database.
- Carro et al. 2011 (Human Ventricle: Epicardial, Endocardial)
Protocols and Physiological Markers
- Steady State: Models are stimulated during 3000 cycles with different Cycle Length (1000 ms, 2000 ms). For each cycle length, in the last cycle, the following markers are calculated and saved.
- APD: Action Potential Duration at different percentages of repolarization (90, 75, 50, 25).
- Systolic and Diastolic: Maximum and minimum value of the ionic concentration in the last cycle.